A5044730858- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Autoimmune Neurological Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- Glaucoma and retinal disorders
- CNS Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Chromosomal and Genetic Variations
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Long-Term Effects of COVID-19
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced Neuroimaging Techniques and Applications
- Viral Infections and Immunology Research
- Protein Tyrosine Phosphatases
- Sarcoidosis and Beryllium Toxicity Research
- T-cell and B-cell Immunology
- interferon and immune responses
- Cerebral Venous Sinus Thrombosis
- Cellular transport and secretion
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
1997-2025
Humboldt-Universität zu Berlin
2016-2025
Euroimmun Medizinische Labordiagnostika (Germany)
2024
Heidelberg University
2012-2024
Oklahoma Medical Research Foundation
2024
Max Delbrück Center
2016-2024
Heinrich Heine University Düsseldorf
2021-2024
University of California, Irvine
2020-2023
University of California, San Francisco
2020-2023
A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features a large cohort MOG-IgG-positive optic neuritis (ON) and/or myelitis (n = 50) as well attack long-term treatment outcomes. Retrospective multicenter study. The sex ratio was 1:2.8 (m:f). Median age at onset 31...
Abstract Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so far about the clinical impact AQP4-Ab seropositivity. Objective To analyse systematically paraclinical features associated NMO Caucasians a stratified fashion according patients' serostatus. Methods Retrospective study 175 Caucasian (AQP4-Ab positive 78.3%). Results...
Abstract Background Alzheimer disease (AD) is the most common form of dementia but identification reliable, early and non-invasive biomarkers remains a major challenge. We present novel miRNA-based signature for detecting AD from blood samples. Results apply next-generation sequencing to miRNAs samples 48 patients 22 unaffected controls, yielding total 140 unique mature with significantly changed expression levels. Of these, 82 have higher 58 lower abundance in patient selected panel 12 an...
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested play a role in subset of patients with neuromyelitis optica and related disorders.To assess (i) the frequency MOG-IgG large predominantly Caucasian cohort optic neuritis (ON) and/or myelitis; (ii) among AQP4-IgG-positive vice versa; (iii) origin cerebrospinal fluid (CSF); (iv) presence at disease onset; (v) influence activity treatment status on titers.614 serum samples from ON myelitis controls, including 92...
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, which heterogenous with respect to clinical manifestations and response therapy. Identification biomarkers appears desirable for an improved diagnosis MS as well monitoring activity treatment response. MicroRNAs (miRNAs) are short non-coding RNAs, have been shown potential serve different human diseases, most notably cancer. Here, we analyzed expression profiles 866 miRNAs. In detail,...
Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants autoimmune targeting neuronal surface antigens. However, neuroimaging pattern and long-term cognitive outcome are not well understood.To study structural magnetic resonance imaging (MRI) alterations in patients anti-LGI1 encephalitis.A cross-sectional was conducted at Departments Neurology Charité-Universitätsmedizin Berlin University Hospital Schleswig-Holstein, Kiel, Germany....
We identified a novel human polyomavirus from kidney transplant patient under immunosuppressive treatment, by use of generic PCR. The genome the virus was completely amplified and sequenced. In phylogenetic analyses, it appeared as closest relative to African green monkey-derived lymphotropic (LPV). Further investigation clinical samples immunocompromised patients with specific nested PCR revealed additional positive samples, indicating that naturally infects humans. tentatively named 9...
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are present in a subset of aquaporin-4 (AQP4)-IgG-negative patients with optic neuritis (ON) and/or myelitis. Little is known so far about brainstem involvement MOG-IgG-positive patients. To investigate the frequency, clinical and paraclinical features, course, outcome, prognostic implications ON Retrospective case study. Among 50 myelitis, 15 (30 %) history encephalitis were identified. All negative for AQP4-IgG. Symptoms included...
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage the retina MOG-IgG-positive comparison AQP4-IgG-positive NMOSD patients.Afferent visual system following ON bilaterally assessed 16 a history and compared that patients. In addition, healthy controls matched for...
To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR).This retrospective cohort study was based on registry German Neuromyelitis Optica Study Group, a nationwide network established 2008. It recruited patients with diagnosed according 2006 Wingerchuk criteria aquaporin-4...
We assessed the therapeutic potential of plasma-cell-depleting proteasome inhibitor bortezomib in severe and therapy-refractory cases anti-NMDA receptor (anti-NMDAR) encephalitis.Five severely affected patients with anti-NMDAR encephalitis delayed treatment response or resistance to standard immunosuppressive B-cell-depleting drugs (corticosteroids, IV immunoglobulins, plasma exchange, immunoadsorption, rituximab, cyclophosphamide) who required medical artificial ventilation on intensive...
Abstract Background Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far. Objective To analyze systematically CSF COVID-19. Methods Retrospective analysis of 150 lumbar punctures 127 PCR-proven symptoms seen at 17 European university centers Results The most frequent pathological finding was blood-CSF barrier (BCB) dysfunction (median QAlb 11.4 [6.72–50.8]), which present...
To investigate distinct white matter and cortical gray pathology in neuromyelitis optica spectrum disorders (NMOSDs) multiple sclerosis (MS) at 7-T MRI a cross-sectional study.We included 10 patients with NMOSDs 18 MS our study. The imaging protocol comprised T2*-weighted fast low angle shot turbo inversion recovery magnitude sequences. White lesions were assessed special regard to their (perivascular) localization as well the expression of hypointense rim.In total, we detected 140 7 NMOSDs....
Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that are directly involved in the immunopathogenesis NMO. Objective To assess frequency, syndrome specificity, diagnostic relevance, and origin cerebrospinal fluid (CSF) patients NMO spectrum disorders (NMOSD). Methods 87 CSF samples from 37 NMOSD 42 controls other neurological diseases were...
The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family 'W' (HERV-W), induces dysimmunity and inflammation.The objective this study was to confirm specify association between HERV-W/MSRV (Env) expression MS.103 MS, 199 healthy controls (HC) with other neurological diseases (28), chronic infections (30) or autoimmunity were analysed an immunoassay detecting Env in serum. RNA DNA copy numbers peripheral blood...
Background Neuromyelitis optica (NMO) and relapsing-remitting multiple sclerosis (RRMS) are difficult to differentiate solely on clinical grounds. Optical coherence tomography (OCT) studies investigating retinal changes in both diseases focused primarily the nerve fiber layer (RNFL) while rare data available deeper intra-retinal layers. Objective To detect different patterns of alterations patients with NMO spectrum disorders (NMOSD) RRMS focus influence a previous optic neuritis (ON)....
We aimed to evaluate racial differences in the clinical features of neuromyelitis optica spectrum disorder.This retrospective review included 603 patients (304 Asian, 207 Caucasian, and 92 Afro-American/Afro-European), who were seropositive for anti-aquaporin-4 antibody, from 6 centers Denmark, Germany, South Korea, United Kingdom, States, Thailand.Median disease duration at last follow-up was 8 years (range 0.3-38.4 years). Asian Afro-American/Afro-European had a younger onset age than...
Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorders. However, whether human MOG antibodies pathogenic or an epiphenomenon is still not completely clear. Although highly conserved within mammals, previous findings showed that all bind rodent MOG. We therefore hypothesized antibody-mediated pathology in...