A5016397545- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Tyrosine Phosphatases
- Retinal and Optic Conditions
- Neurogenesis and neuroplasticity mechanisms
- Sphingolipid Metabolism and Signaling
- Ocular Diseases and Behçet’s Syndrome
- Polyomavirus and related diseases
- Hereditary Neurological Disorders
- Glycosylation and Glycoproteins Research
- Autoimmune Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Herpesvirus Infections and Treatments
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- CNS Lymphoma Diagnosis and Treatment
- Vasculitis and related conditions
- Long-Term Effects of COVID-19
- Macrophage Migration Inhibitory Factor
- Autoimmune Bullous Skin Diseases
University of Colorado Anschutz Medical Campus
2014-2025
University of Colorado Denver
2015-2024
University of Colorado System
2020-2024
John Wiley & Sons (United States)
2023-2024
University of Bern
2023
University Hospital of Bern
2023
University of Glasgow
2023
Inserm
2023
Charité - Universitätsmedizin Berlin
2023
Centre National de la Recherche Scientifique
2023
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or extensive may occur. The International Panel for Diagnosis (IPND) was convened to develop revised using systematic literature reviews electronic surveys facilitate consensus. new nomenclature defines the unifying term...
There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only few CSF are being used clinical practice. One the most critical factors biomarker inadequate powering studies because lack sufficient samples that can be obtained single-center studies. Therefore, collaboration between investigators needed to establish large biobanks well-defined samples. Standardized protocols for biobanking prerequisite ensure statistical power...
The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in perivessel and subpial areas brain. Our objectives were to determine source central nervous system (CNS) NMO-IgGs their role disease pathogenesis.Fluorescence-activated cell sorting single-cell reverse transcriptase polymerase chain reaction used identify overrepresented plasma immunoglobulin (Ig) sequences...
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that has an autoimmune pathogenesis; target immune response not yet known.We screened serum IgG from persons with multiple to identify antibodies are capable binding brain tissue and observed specific glial cells in subgroup patients. Using proteomic approach focusing on membrane proteins, we identified ATP-sensitive inward rectifying potassium channel KIR4.1 as antibodies....
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO-immunoglobulin [Ig]G) against astrocyte water channel aquaporin-4 (AQP4) cause complement- and cell-mediated damage with consequent neuroinflammation demyelination. Current NMO therapies, which have limited efficacy, include immunosuppression plasma exchange. The objective this study was to develop a potential new therapy based on blocking pathogenic NMO-IgG...
Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse patients MOGAD, we conducted a multicenter retrospective study to rate on various treatments.
Blood tests to monitor disease activity, attack severity, or treatment impact in neuromyelitis optica spectrum disorder (NMOSD) have not been developed. This study investigated the relationship between serum glial fibrillary acidic protein (sGFAP) concentration and NMOSD activity assessed of inebilizumab treatment.N-MOmentum was a prospective, multicenter, double-blind, placebo-controlled, randomized clinical trial adults with NMOSD. sGFAP levels were measured by single-molecule arrays...
CHAMPION-NMOSD (NCT04201262) is a phase 3, open-label, externally controlled interventional study evaluating the efficacy and safety of terminal complement inhibitor ravulizumab in adult patients with anti-aquaporin-4 antibody-positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD). Ravulizumab binds same component 5 epitope as approved therapeutic eculizumab but has longer half-life, enabling an extended dosing interval (8 vs 2 weeks).The availability precluded use concurrent...
Recent studies suggest that maintenance intravenous immunoglobulin (IVIG) may be an effective treatment to prevent relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); however, most of these had pediatric cohorts, and few have evaluated IVIG adult patients.To determine the association with prevention relapse a large cohort patients MOGAD.This was retrospective study conducted from January 1, 2010, October 31, 2021. Patients were recruited 14 hospitals 9...
Importance Biomarkers distinguishing nonrelapsing progressive disease biology from relapsing in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an accessible that most closely reflects central nervous system biology. Objective To identify CSF biological measures associated with MS pathobiology. Design, Setting, and Participants This cohort study assessed data 2 prospective cohorts: a test provided serial CSF, clinical, imaging assessments multicenter of patients (RMS) or...
Abstract Objective Intrathecal IgG synthesis, persistence of bands oligoclonal IgG, and memory B‐cell clonal expansion are well‐characterized features the humoral response in multiple sclerosis (MS). Nevertheless, target antigen this remains enigmatic. Methods We produced 53 different human IgG1 monoclonal recombinant antibodies (rAbs) by coexpressing paired heavy‐ light‐chain variable region sequences 51 plasma cell clones 2 B‐lymphocyte from MS cerebrospinal fluid tissue culture cells....
Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for the neuroinflammatory disease neuromyelitis optica (NMO). We measured binding of NMO autoantibodies to AQP4 in human astrocyte-derived U87MG cells expressing M1 and/or M23 AQP4, or mutants that do not form orthogonal array particles (OAPs). Binding affinity was quantified by two-color fluorescence ratio imaging stained with serum a recombinant monoclonal autoantibody (NMO-rAb), together C terminus...
<b>Objective:</b> Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that becomes latent in B-lymphocytes and has been implicated the pathogenesis of multiple sclerosis (MS). We searched for active EBV infection MS brain CSF. <b>Methods:</b> Nested non-nested real-time PCR were used to detect cell-specific EBV-specific transcripts 15 fresh-frozen 5 formalin-fixed paraffin-embedded plaques single CSF plasma cells. Intrathecal anti-EBV antibody synthesis was measured by ELISA....