A5043673303- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Polyomavirus and related diseases
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- RNA regulation and disease
- CNS Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Hereditary Neurological Disorders
- Glioma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Cerebrospinal fluid and hydrocephalus
- Myasthenia Gravis and Thymoma
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Electrolyte and hormonal disorders
- Monoclonal and Polyclonal Antibodies Research
- Advanced Neuroimaging Techniques and Applications
- Viral Infections and Immunology Research
- Sphingolipid Metabolism and Signaling
- Ion Transport and Channel Regulation
- Cerebrovascular and genetic disorders
Mayo Clinic in Arizona
2015-2025
Mayo Clinic
2016-2025
WinnMed
2007-2025
DELL (United States)
2025
The University of Texas at Austin
2024
Mayo Clinic in Florida
2008-2023
Neurology, Inc
2008-2023
Vita-Salute San Raffaele University
2022-2023
Jacksonville College
2009-2022
University of Sassari
2022
Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course, neuroradiological appearance of the lesions, involvement susceptibility gene loci, and response to therapy. These features are supported by experimental evidence, which demonstrates that fundamentally different processes, such as autoimmunity or virus infection, may induce MS-like inflammatory demyelinating plaques suggest MS be heterogeneous pathogenetic mechanisms. From large pathology sample MS, collected...
Background: The authors previously proposed diagnostic criteria for neuromyelitis optica (NMO) that facilitate its distinction from prototypic multiple sclerosis (MS). However, some patients with otherwise typical NMO have additional symptoms not attributable to optic nerve or spinal cord inflammation MS-like brain MRI lesions. Furthermore, are misclassified as by the authors’ earlier despite having a subsequent course indistinguishable MS. A serum autoantibody marker, NMO-IgG, is highly...
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain patient's clinical deficits. We thus analysed global brain pathology sclerosis, focusing on normal-appearing matter (NAWM) and cortex. Autopsy tissue from 52 patients (acute, relapsing-remitting, primary secondary progressive sclerosis) 30 controls was using quantitative morphological techniques. New active focal inflammatory demyelinating lesions were mainly present...
Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may occur independently from inflammation. The aim of our study was to analyse the interdependence inflammation, and disease progression various sclerosis stages relation lesional activity clinical course, with a particular focus on sclerosis. is based detailed quantification different inflammatory cells axonal injury 67 autopsies 28 controls without neurological or brain lesions. We found pronounced...
Devic’s disease [neuromyelitis optica (NMO)] is an idiopathic inflammatory demyelinating of the CNS, characterized by attacks optic neuritis and myelitis. The mechanisms that result in selective localization lesions to nerves spinal cord are unknown. Serological clinical evidence B cell autoimmunity has been observed a high proportion patients with NMO. purpose this study was investigate importance humoral mechanisms, including complement activation, producing necrotizing demyelination seen...
Cortical disease has emerged as a critical aspect of the pathogenesis multiple sclerosis, being associated with progression and cognitive impairment. Most studies cortical lesions have focused on autopsy findings in patients long-standing, chronic, progressive noninflammatory nature these been emphasized. Magnetic resonance imaging indicate that damage occurs early disease.We evaluated prevalence character demyelinating sclerosis. tissues were obtained passing during biopsy sampling...
Chemokines direct tissue invasion by specific leukocyte populations. Thus, chemokines may play a role in multiple sclerosis (MS), an idiopathic disorder which the central nervous system (CNS) inflammatory reaction is largely restricted to mononuclear phagocytes and T cells. We asked whether were expressed CNS during acute demyelinating events analyzing cerebrospinal fluid (CSF), whose composition reflects extracellular space. During MS attacks, we found elevated CSF levels of three that act...
There are no established treatments for patients with acute, severe neurological deficits caused by multiple sclerosis or other inflammatory demyelinating diseases of the central nervous system who fail to recover after treatment high-dose corticosteroids. We conducted a randomized, sham-controlled, double-masked study plasma exchange without concomitant immunosuppressive in recently acquired, resulting from attacks disease, failed intravenous Patients did not achieve moderate greater...
Although spontaneous remyelination does occur in multiple sclerosis lesions, its extent within the global population with this disease is presently unknown. We have systematically analysed incidence and distribution of completely remyelinated lesions (so-called shadow plaques) or partially (shadow plaque areas) 51 autopsies patients different clinical courses durations. The was variable between cases. In 20% patients, extensive 60-96% lesion area remyelinated. Extensive found not only...
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that typically affects optic nerves and spinal cord. Its pathogenic relationship to multiple sclerosis (MS) uncertain. Unlike MS, NMO lesions are characterized by deposits of IgG IgM co-localizing with products complement activation in a vasculocentric pattern around thickened hyalinized blood vessels, suggesting role for humoral immunity targeting antigen the perivascular space. A recently identified specific serum...
<h3>Background</h3> Neuromyelitis optica (NMO)–IgG is a specific autoantibody marker for NMO. It binds selectively to aquaporin 4 (AQP4), which highly concentrated in astrocytic foot processes at the blood-brain barrier and not restricted optic nerve spinal cord. Although it conventionally believed that brain spared, imaging abnormalities are uncommon patients with <h3>Objective</h3> To investigate location of lesions distinctive NMO respect localization AQP4 mammalian brain. <h3>Design</h3>...
Background: Neuromyelitis optica (NMO) is a severe demyelinating disease defined principally by its tendency to selectively affect optic nerves and the spinal cord causing recurrent attacks of blindness paralysis.Contemporary diagnostic criteria require absence clinical outside nerve or cord.We have, however, frequently encountered patients with wellestablished diagnosis NMO in whom either asymptomatic symptomatic brain lesions develop suggesting that for should be revised.Objective: To...
Objective An extensive analysis of white matter plaques in a large sample multiple sclerosis (MS) autopsies provides insights into the dynamic nature MS pathology. Methods One hundred twenty cases (1,220 tissue blocks) were included. Plaque types classified according to demyelinating activity based on stringent criteria. Early active, late smoldering, inactive, and shadow distinguished. A total 2,476 identified. type distribution was analyzed relation clinical data. Results Active most often...
Background: Neuromyelitis optica (NMO) is often associated with other clinical or serological markers of non-organ-specific autoimmunity.Objective: ToevaluatetherelationshipbetweenNMOspectrum disorders (NMOSDs), including NMO, longitudinally extensive transverse myelitis, and recurrent optic neuritis, autoimmune disease.We concentrated on the association systemic lupus erythematosus (SLE), Sjo ¨gren syndrome (SS), evidence these disorders, which commonly a source diagnostic confusion.
Abstract Objective We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse or development optic neuritis. Methods Prospective study patients with LETM who were tested for presence NMO‐IgG. Results Eleven 29 (37.9%) seropositive after a first attack spanning three more vertebral segments on magnetic resonance imaging. Of 23 followed up 1 year, none 14 seronegative experienced...
Background: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), often termed Hashimoto encephalopathy, is a poorly understood and misdiagnosed entity.Objective: To characterize the clinical, laboratory, radiologic findings in patients SREAT to potentially improve recognition of this treatable entity.Design: Retrospective analysis clinical features diagnostic test data.Setting: Two affiliated tertiary care referral institutions.Patients: Twenty consecutive (6...
Type 1 antineuronal nuclear autoantibody (ANNA-1, also known as "anti-Hu") is a marker of neurologic autoimmunity that highly associated with small-cell lung carcinoma (SCLC). To determine the spectrum symptoms and signs well frequency cancer in adult patients who are seropositive for ANNA-1, we reviewed 162 sequential (67% female) identified ANNA-1-positive comprehensive immunofluorescence screening test. In 21% these patients, antibody test requested by physician was not ANNA-1. By end...
We report the neuropathological findings of a patient who died from complications COVID-19. The decedent was initially hospitalized for surgical management underlying coronary artery disease. He developed post-operative and evaluated with chest imaging studies. computed tomography (CT) results were indicative COVID-19 he subsequently tested SARS-CoV-2, which positive. His condition worsened after more than 2 weeks hospitalization aggressive treatment. autopsy revealed range lesions, features...