A5060200677- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Myasthenia Gravis and Thymoma
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Cancer Treatment and Pharmacology
- Polyomavirus and related diseases
- Hereditary Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Glycogen Storage Diseases and Myoclonus
- Brain Metastases and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Pharmacological Receptor Mechanisms and Effects
- Multiple Sclerosis Research Studies
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Management of metastatic bone disease
- Advanced Radiotherapy Techniques
- Parkinson's Disease and Spinal Disorders
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
University of Maryland, Baltimore
2022
Barrow Neurological Institute
2022
Libin Cardiovascular Institute of Alberta
2021
Vanderbilt University Medical Center
2021
University of Calgary
2021
Pennsylvania State University
2021
Mayo Clinic in Florida
1998-2019
Parkland Health & Hospital System
2017
Idiopathic autonomic neuropathy is a severe, subacute disorder with presumed autoimmune basis. It indistinguishable from the that may accompany lung cancer or other tumors. Autoantibodies specific for nicotinic acetylcholine receptors in ganglia are potentially pathogenic and serve as serologic markers of various forms neuropathy.We tested serum 157 patients variety types dysautonomia. Immunoprecipitation assays iodine-125-labeled epibatidine solubilized human neuroblastoma were used to...
Background: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), often termed Hashimoto encephalopathy, is a poorly understood and misdiagnosed entity.Objective: To characterize the clinical, laboratory, radiologic findings in patients SREAT to potentially improve recognition of this treatable entity.Design: Retrospective analysis clinical features diagnostic test data.Setting: Two affiliated tertiary care referral institutions.Patients: Twenty consecutive (6...
<b><i>Objectives:</i></b> To describe the clinical features and coexisting serum autoantibodies in seven patients with encephalitis associated to α-dendrotoxin-sensitive voltage-gated potassium channels (VGKCs), compare this disorder other autoimmune encephalopathies. <b><i>Methods:</i></b> Clinical information was obtained from a retrospective review of medical records telephone interviews. All autoantibody testing performed single laboratory. <b><i>Results:</i></b> The were examined for...
Autoimmune epilepsy is an underrecognized condition, and its true incidence unknown. Identifying patients with underlying autoimmune origin critical because these patients' condition may remain refractory to conventional antiseizure medications but respond immunotherapy.To determine the prevalence of neurological autoantibodies (Abs) among adult unknown etiology.Consecutive presenting neurology services new-onset or established etiology were identified. Serum samples tested for encephalitis...
Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by intolerance with excessive heart rate increase without hypotension during upright posture. Patients experience constellation of other typical symptoms including fatigue, exercise gastrointestinal distress. A patient POTS female child-bearing age, who first displays in adolescence. The onset may be precipitated immunological stressors such as viral infection. variety pathophysiologies...
Autoimmune encephalitis misdiagnosis can lead to harm.To determine the diseases misdiagnosed as autoimmune and potential reasons for misdiagnosis.This retrospective multicenter study took place from January 1, 2014, December 31, 2020, at subspecialty outpatient clinics including Mayo Clinic (n = 44), University of Oxford 18), Texas Southwestern California, San Francisco 17), Washington in St Louis 6), Utah 4). Inclusion criteria were adults (age ≥18 years) with a prior diagnosis...
Importance Finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (Parkinson disease [PD], dementia with Lewy bodies [DLB], multiple system atrophy [MSA], and pure autonomic failure [PAF]) is an urgent unmet need. Immunohistochemical detection of cutaneous phosphorylated α-synuclein may be sensitive specific clinical test diagnosis synucleinopathies. Objective To evaluate positivity rate deposition in patients PD, DLB, MSA, PAF. Design, Setting,...
Mortality after cerebral infarction (CI) has remained unchanged during the past 20 years, despite advances in neurologic care. Key factors affecting survival may be underrecognized. The purpose of this study was to determine rate and cause mortality first CI.In case-control, population-based study, all available medical records were reviewed for Rochester (Minnesota) residents with a CI between 1985 1989 identify morbidities death. Predictors analyzed.First recorded 444 patients. Survival...
<b>Background</b> Autoantibodies specific for the acetylcholine receptor (AChR) of skeletal muscle (containing α1 subunit) impair neuromuscular transmission in myasthenia gravis (MG). AChRs mediating fast synaptic through autonomic ganglia are structurally similar to AChR, but contain α3 subunit. We propose that ganglionic AChR autoimmunity may cause dysautonomia. <b>Objective</b> To test serum patients with neuropathy autoantibodies neuronal specificity. <b>Methods</b> developed an...
Abstract Paraneoplastic chorea is described in 16 patients: 11 with limited small‐cell carcinoma, 2 lung cancer revealed by imaging, 1 renal cell and lymphoma. All had CRMP‐5‐IgG; 6 also ANNA‐1 (anti‐Hu), including without evident cancer. Chorea was the initial most prominent symptom patients, asymmetric or unilateral 5 part of a multifocal syndrome 14 patients. Basal ganglia abnormalities were magnetic resonance imaging at autopsy (as perivascular inflammation microglial activation). Four...
Paraneoplastic neurological disorders are devastating remote effects of malignancy. Despite compelling evidence an autoimmune pathogenesis, empiric immunomodulatory treatment these is often ineffective. However, very few systematic studies have been conducted, and the patients without active malignancy has not addressed. We conducted a prospective open-label study plasma exchange plus conventional cancer chemotherapy (10 patients) or continuous oral cyclophosphamide patients). All had...
Abstract We analyzed the clinical characteristics of 18 patients (13 female, 5 male) who had autoimmune autonomic neuropathy (AAN) and ganglionic acetylcholine receptor (AChR) autoantibodies. Mean age was 61.4 years (standard deviation, 12.0 years). Ten subacute symptom onset, six with an antecedent event. Eight chronic AAN, characterized by insidious without event, gradual progression. A majority high antibody values (>1.00 nmol/L) a combination sicca complex (marked dry eyes mouth),...
Abstract Purpose: Determine muscle and neuronal autoantibody frequencies in patients with thymoma, without paraneoplastic neurological accompaniments. Experimental Design: Analysis of IgG autoantibodies stored serum collected between 1985 2003 from 201 histologically diagnosed thymoma (including six thymic carcinoma). Contemporary assays quantitated antibodies reactive cation channels, sarcomeric proteins cytoplasmic, nuclear proteins. Results: Neurological diagnoses included myasthenia...