A5001048805- Dialysis and Renal Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Nutrition and Health in Aging
- Genetic and Kidney Cyst Diseases
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Muscle and Compartmental Disorders
- Blood Pressure and Hypertension Studies
- Biomarkers in Disease Mechanisms
- Blood properties and coagulation
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Erythropoietin and Anemia Treatment
- Metabolism and Genetic Disorders
- Biomedical Research and Pathophysiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Syndromes and Imprinting
- Adipose Tissue and Metabolism
- Clinical Nutrition and Gastroenterology
- Pituitary Gland Disorders and Treatments
Karolinska University Hospital
2008-2021
Lund University
2019-2021
Karolinska Institutet
2008-2019
Matrix Research (United States)
2017
Baxter (Sweden)
2005-2014
Baxter (United States)
2005-2007
Hangzhou Hospital of Traditional Chinese Medicine
2007
Universidade Federal de São Paulo
2007
Hospital Universitario La Paz
2007
University of Florida
2006
Abstract. Objective. The lifespan of dialysis patients is as short in with metastatic cancer disease, mainly due to cardiovascular disease (CVD). DNA methylation an important cellular mechanism modulating gene expression associated ageing, inflammation and atherosclerotic processes. Design. was analysed peripheral blood leucocytes from three different groups chronic kidney (CKD) populations (37 CKD stages 3 4 patients, 98 stage 5 20 prevalent haemodialysis patients). Thirty‐six healthy...
Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by intolerance with excessive heart rate increase without hypotension during upright posture. Patients experience constellation of other typical symptoms including fatigue, exercise gastrointestinal distress. A patient POTS female child-bearing age, who first displays in adolescence. The onset may be precipitated immunological stressors such as viral infection. variety pathophysiologies...
Abstract. Carrero JJ, Qureshi AR, Axelsson J, Yilmaz MI, Rehnmark S, Witt MR, Bárány P, Heimbürger O, Suliman ME, Alvestrand A, Lindholm B, Stenvinkel P (Karolinska Institutet, Stockholm; and Karo Bio AB, Novum, Huddinge; Sweden). Clinical biochemical implications of low thyroid hormone levels (total free forms) in euthyroid patients with chronic kidney disease. J Intern Med 2007; 262 : 690–701. Objectives. In this study, we explore the associations decreased inflammation, wasting survival...
Plasma protein pentraxin 3 concentrations are elevated in a wide range of diseased states. However, no study has evaluated patients with chronic kidney disease.Plasma were analyzed relation to GFR, inflammation, cardiovascular disease, and protein-energy wasting 71 stages 4 276 stage 5 61 control subjects. Survival (5 yr) disease was levels.Both patient groups had higher than subjects, the highest concentration disease. In all correlated negatively GFR positively inflammatory markers....
Vascular calcification and endothelial dysfunction contribute to the development of cardiovascular disease in patients with chronic kidney (CKD). Sevelamer, a non-calcium-based phosphate binder, has been shown attenuate CKD patients, although exact mechanism not clarified. This study was designed investigate effect short-term sevelamer treatment on both serum fetuin-A concentrations seen patients.Fifty nondiabetic stage 4 whose levels were > or =5.5 mg/dl enrolled this 8-wk randomized...
Background . Endothelial dysfunction (ED) is common in patients with moderate to advanced chronic kidney disease (CKD). Recently, visfatin, a protein insulin-mimetic properties, was shown be associated sVCAM-1. Thus, we hypothesised that visfatin may marker of ED CKD. Methods We studied 406 different stages non-diabetic CKD (50% males, 46 ± 12 years), testing the relationship between flow-mediated dilatation (FMD), assessed by high resolution brachial ultrasonography, and plasma adiponectin...
Asymmetric dimethyl-arginine (ADMA), a residue of the proteolysis arginine-methylated proteins, is potent inhibitor nitric oxide synthesis. The increased protein turnover that accompanies proteinuric secondary amyloidosis may increase circulating levels ADMA, and this contribute to endothelial dysfunction. We performed cross-sectional study 121 nondiabetic patients with normal GFR (including 39 nephrotic-range proteinuria amyloidosis) 50 age-, sex-, BMI-matched healthy controls. had higher...
The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state understanding pathophysiology postural orthostatic tachycardia syndrome (POTS) and identify knowledge gaps that must be addressed enhance clinical care POTS patients through research. This second (of two) articles summarizes gaps, outlines research priorities for POTS.POTS is complex, multi-system, chronic disorder autonomic nervous system characterized by intolerance without hypotension....
Background and objectives: Long pentraxin 3 (PTX3) is a multimeric inflammatory mediator. Increased serum PTX3 levels have been reported among end-stage renal disease patients. Moreover, has suggested to represent novel mortality risk factor, elevated shown accompany increased albuminuria patients with chronic kidney (CKD). Design, setting, participants, & measurements: We analyzed data of 49 persons stage 1 diabetic CKD 32 healthy subjects in prospective controlled trial. Endothelial...
Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and intolerance. Previous data indicate autoimmune involvement. We studied serum activity against G protein–coupled receptors in relation to symptoms patients with POTS controls using a commercial cell‐based assay. Methods Results Forty‐eight (aged 28.6±10.5 years; 44 women) 25 healthy individuals 30.7±8.6 21 were included. The 10‐item Orthostatic Hypotension...