A5100436989- Cardiovascular Function and Risk Factors
- Parathyroid Disorders and Treatments
- Cardiac Fibrosis and Remodeling
- Dialysis and Renal Disease Management
- Phytochemistry and Biological Activities
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Iron Metabolism and Disorders
- MicroRNA in disease regulation
- Essential Oils and Antimicrobial Activity
- Cancer-related gene regulation
- Migraine and Headache Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Nutrition and Health in Aging
- Neuroscience of respiration and sleep
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Macrophage Migration Inhibitory Factor
- Cardiac electrophysiology and arrhythmias
- Selenium in Biological Systems
- Plant Gene Expression Analysis
Chinese Academy of Tropical Agricultural Sciences
2014-2024
Tropical Crops Genetic Resources Institute
2024
Ministry of Agriculture and Rural Affairs
2024
Zhejiang Chinese Medical University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2024
China Pharmaceutical University
2024
Nanjing Medical University
2011-2023
Jiangsu Province Hospital
2011-2023
Tianjin Medical University Cancer Institute and Hospital
2022
Exercise training benefits the heart. The knowledge of post-transcription regulation, especially RNA editing, in hearts remain rare. ADAR2 is an enzyme that edits adenosine to inosine nucleotides double-stranded RNA, and editing associated with many human diseases. We found was upregulated during exercise training. AAV9-mediated cardiac-specific overexpression attenuated acute myocardial infarction (AMI), MI remodeling, doxorubicin (DOX)-induced cardiotoxicity. In vitro, inhibited...
Diabetes is a critical contributor to the pathogenesis of cardiovascular diseases. Klotho an anti-aging protein with cardiovascular-renal protective effects. However, relationship between serum levels and diabetes remains poorly understood.This study aimed investigate in US adults.We analyzed cross-sectional data obtained from 13751 subjects aged 40-79 years National Health Nutrition Examination Survey (NHANES) (2007-2016). Serum concentration was measured using enzyme-linked immunosorbent...
Allisartan isoproxil is a new nonpeptide angiotensin II receptor blocker (ARB) precursor drug that used to treat hypertension and reduce the risk of heart disease. The present study explored effects allisartan on diabetic cardiomyopathy (DCM) revealed roles hyperglycaemia‑induced oxidative stress inflammation. A rat DCM model was established by high‑fat diet feeding in combination with intraperitoneal injection streptozocin. Echocardiographs showed rats exhibited significantly decreased...
Abstract Cardio-renal fibrosis plays key roles in heart failure and chronic kidney disease. We sought to determine the effects of renal denervation (RDN) on cardiac rats with isoproterenol induced cardiomyopathy. Sixty male Sprague Dawley were randomly assigned Control (n = 10) (ISO)-induced cardiomyopathy group 50). At week 5, 31 survival ISO-induced randomized RDN 15) Sham 16). Compared group, ejection fraction was decreased, diastolic interventricular septal thickness left atrial...
Abstract Background Autophagy is a double-edged sword during the initiation and progression of multiple tumors. The Hippo pathway effector YAP has been proved to be involved in autophagy processes. present study aimed investigate how regulates cell proliferation via lung adenocarcinomas (LUAD). Methods Data LUAD chip GSE43458 was obtained from Gene Expression Omnibus (GEO). RT-qPCR Western blot were performed assess expression lines. CCK-8 assay, xenograft tumor model, immunochemistry...
Abstract Lung cancer has one of the highest morbidity and mortality rates in world. Frailty is common many countries a major cause premature functional decline death older adults, may affect treatment prognosis lung patients. To investigate predictive value frailty at diagnosis on all-cause patients, this study retrospectively collected analysed clinical information patients from 2015–2018. A total 1667 with primary were finally included study. The median follow-up time was 650 (493, 1001.5)...
Abstract: A variety of nanoscale delivery systems have been shown to enhance the oral absorption poorly water-soluble and permeable drugs. However, performance these has seldom evaluated simultaneously. The aim this study was compare bioavailability enhancement effect lipid-based nanocarriers with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) highlight importance lipid composition, cyclosporine (CyA) as a model drug. CyA-loaded PLGA NPs, nanostructured carriers (NLCs),...
Abstract Aim Renal denervation ( RDN ) has beneficial effects on cardiac remodelling and function in resistant hypertension. We aimed to investigate the impact of angiogenesis during prolonged pressure overload. Methods Cardiac overload was reproduced by transverse aorta constriction TAC procedure adult Sprague Dawley male rats n = 35). /sham‐ performed surviving at 5 weeks after . Results Five post‐ , transthoracic echocardiography revealed that myocardial hypertrophy occurred rats, with...
Background Cardiovascular disease (CVD) poses a tremendous threat to global health, giving rise exceedingly high morbidity and mortality among patients. A migraine is common neurological disorder characterized by recurrent attacks of severe headache, while its cardiovascular burden remains unclear. Therefore, this study aims investigate whether associated with CVD. Methods The cross-sectional data 5,692 subjects aged 20 or above was obtained from the National Health Nutrition Examination...
Great achievements have been achieved by free antiretroviral therapy (ART). A rapid and accurate prediction of survival in people living with HIV/AIDS (PLHIV) is needed for effective management. We aimed to establish an prognostic model forecast the PLHIV after ART.The participants were enrolled from a follow-up cohort over 2003-2019 Nanjing AIDS Prevention Control Information System. nested case-control study was employed HIV-related death, propensity-score matching (PSM) approach applied...
Abstract The gut microbiota seems to be a major modulator of cardiovascular diseases, such as myocardial infarction. Dapagliflozin, sodium glucose cotransporter 2 inhibitor (SGLT2i), is an antidiabetic agent that was recently utilized in patients with diseases. This study aims investigate the effects dapagliflozin on faecal postinfarction non‐diabetic mice. A total 19 male mice were randomly divided into three groups, where two groups enduced infarction (MI) by left anterior descending...
Abstract As a commonly used medicinal plant, the flavonoid metabolites of Blumea balsamifera and their association with genes are still elusive. In this study, total content (TFC), biosynthetic gene expression patterns B. after application exogenous methyl jasmonate (MeJA) were scrutinized. The different concentrations MeJA increased TFC leaves 48 h exposure, there was positive correlation between elicitor concentration. A metabolites, falling into 10 structural classes, identified, among...
Background/Aims: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy. Methods: An cardiomyopathy model was reproduced infarction (MI) adult Sprague–Dawley male rats. The RDN/Sham-RDN procedure performed at 2 weeks after MI. Sham-MI sham-RDN served as control group. At 4 RDN, programmed electrical stimulation (PES) used to induce VAs, including tachycardia fibrillation, all 3 groups (MI+RDN, MI,...
Ainaxiang (Blumea balsamifera), also known as Sambong, is an important ancient medicinal herb in Southeast Asia. It rich volatile oil, and still widely used nowadays for skin wound healing treatment of sore throats. We analyzed the oil from Blumea balsamifera (BB oil) by gas chromatography-mass spectrometry (GC-MS). Forty one components, including l-borneol, were identified. Next, damaging effects BB diluted with olive on liver at different concentrations (100%, 50%, 20%), evaluated, using...
Clinical assessment and treatment guidance for heart failure depends on a variety of biomarkers. The objective this study was to investigate the prognostic predictive value growth differentiation factor-15 (GDF-15) N-terminal prohormone brain natriuretic peptide (NT-proBNP) in assessing hospitalized patients with acute (AHF).
Aims: To investigate the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP), Glomerular Filtration Rate (GFR) and outcomes in patients hospitalized with acute heart failure (AHF). Methods: The trial was registered at http://www.chictr.org/cn/. (ChiCTR – ONC - 12001944). A total of 493 for AHF cardiology department First Affiliated Hospital Nanjing Medical University from March 2012 to October 2016 were enrolled into registry. end event occurrence all-cause death...