A5002763775- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Ultrasound and Hyperthermia Applications
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Ultrasound and Cavitation Phenomena
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiovascular Effects of Exercise
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Sepsis Diagnosis and Treatment
- Elasticity and Material Modeling
- Tissue Engineering and Regenerative Medicine
- S100 Proteins and Annexins
- Coronary Interventions and Diagnostics
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2015-2024
China Power Engineering Consulting Group (China)
2024
Shandong Electric Power Engineering Consulting Institute Corp
2024
East China Normal University
2024
Shihezi University
2024
Institute of Cardiology
2019
Wuxi People's Hospital
2019
University of Nebraska Medical Center
2019
Beijing Institute of Technology
2012-2015
Congenital anomalies of arterial valves are common birth defects, leading to valvar stenosis. With no pharmaceutical treatment that can prevent the disease progression, prosthetic replacement is only choice treatment, incurring considerable morbidity and mortality. Animal models presenting localized stenosis congenital similar humans critically needed research tools uncover developmental molecular mechanisms underlying this devastating human condition. We generated characterized mouse with...
BACKGROUNDLeft bundle branch block (LBBB) represents a frequently encountered conduction system disorder. Despite its widespread occurrence, continual dilemma persists regarding intricate association with underlying cardiomyopathy and pivotal role in the initiation of dilated cardiomyopathy. The pathological alterations linked to LBBB-induced (LBBB-CM) have remained elusive.OBJECTIVEThis study sought investigate chronologic dynamics LBBB left ventricular dysfunction mechanism...
ABSTRACT Angiogenesis is crucial for minimising ischemic injury postmyocardial infarction (MI), making it a significant target cardioprotective therapies. While Kindlin‐3 has been linked to angiogenesis in breast cancer, its specific function the context of MI remains largely unexplored. Although implicated cancer‐related angiogenesis, role underexplored. This study investigates promoting process critical cardiac recovery following MI. The demonstrated upregulation microvascular endothelial...
Cardiac fibrosis following myocardial infarction (MI) results in heart failure. Caveolin-1, the main structural protein of caveolae, regulates signal transduction pathways controlling cell proliferation and apoptosis. Meanwhile, low phosphatase tensin homolog (PTEN) activity enhances PI3K/Akt pathway to induce proliferation. But whether caveolin-1 PTEN activation cardiac fibroblast contributes from ischemic injury is incompletely understood. This study investigates hypoxia inducing...
Although small trials have detected microvascular obstruction (MVO) with variable frequency following restoration of epicardial blood flow, the independent impact abnormal perfusion (MVP) in predicting patient outcome emergent percutaneous coronary intervention acute ST-segment-elevation myocardial infarction is unknown. The study aims to determine MVP successful recanalization infarction.MVP was analyzed by low mechanical index ultrasound imaging within 48 hours 297 patients who had...
Abstract Objectives : This study was designed to determine the safety and efficiency of asymmetric symmetric ventricular septal occluders (AVSDOs SVSDOs, respectively) for closure perimembranous defect (PMVSD) in children. Methods Between January 2003 December 2007, 142 children with PMVSD were treated (64 AVSDOs 78 SVSDOs). Results The diameter 5.3 ± 1.1 mm AVSDO group 5.4 1.3 SVSDO ( P > 0.05). success rates similar between two groups [93.8% (AVSDO) vs. 94.9% (SVSDO), 0.05]. Two...
J Clin Hypertens (Greenwich) . 2012;14:245–249. ©2012 Wiley Periodicals, Inc. Atorvastatin is postulated to improve arterial stiffness in patients with diabetes mellitus or hypercholesterolemia; however, elderly hypertensive patients, its effect on and the possible mechanisms are unknown. A total of 73 were enrolled receive atorvastatin for 6 months. Brachial‐ankle pulse wave velocity (baPWV) circulating biomarkers measured before after intervention. After months treatment, experienced a...
As a newly identified factor in calcium-activated chloride channel, ANO1 participates various physiological processes like proliferation and differentiation, expresses human cardiac fibroblasts. In this experiment, we investigated the function of fibrosis after myocardial infraction (MI) with methods Western blotting, Quantitative real-time PCR (qRT-PCR), metabolic reduction 3-(4,5-dimethylthiozol-2-yl)-2, 5-diphenyltetrazo-lium bromide (MTT), immunofluorescence confocal imaging, Masson's...
Hemodialysis (HD) can influence end-stage renal disease (ESRD) patients' circulatory system. The present study aimed to evaluate the effect of volume depletion on left ventricular (LV) and atrial (LA) function determine volume-independent parameters before after HD in patients with ESRD.Between January 2018 2019, we recruited long-term (n=40, 51.0±16.4 years), excluding those structural cardiac disease. Echocardiographic parameters, including LV LA volumes, flow Doppler, pulsed tissue...
Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering nanotechnology one which will have far-reaching impact on medical diagnosis therapies. However, properly designing multifunctional satisfy particular diagnostic/therapeutic requirements has been recognized as rather challenging, because there lack comprehensive understanding how the integration nanoparticles to encapsulating...
Sub-harmonic response from ultrasound contrast agent microbubbles has been demonstrated to be an effective modality for noninvasive pressure measurement. In the present study, dependence of ultra-harmonic on ambient overpressure was investigated by both experimental measurements and simulations. measurements, were exposed Gaussian pulses with varied driving frequencies pulse lengths, at acoustic 0.3 MPa. The amplitudes sub- components measured when overpressures 0–25 kPa. At frequency 1.33...