A5036012325- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Microfluidic and Bio-sensing Technologies
- Ultrasonics and Acoustic Wave Propagation
- Ultrasound Imaging and Elastography
- Acoustic Wave Resonator Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Underwater Acoustics Research
- Acoustic Wave Phenomena Research
- Microbial Inactivation Methods
- Phonetics and Phonology Research
- Flow Measurement and Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Geophysical Methods and Applications
- Advancements in Transdermal Drug Delivery
- Neurobiology of Language and Bilingualism
- Infrared Thermography in Medicine
- Nanoparticle-Based Drug Delivery
- Thermography and Photoacoustic Techniques
- Nanopore and Nanochannel Transport Studies
- Reading and Literacy Development
- RNA Interference and Gene Delivery
- Ocean Waves and Remote Sensing
- Oceanographic and Atmospheric Processes
Leiden University
2012-2024
East China Normal University
2015-2024
University of Vermont
2012-2022
Texas A&M University
2022
Huizhou Central People's Hospital
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
Guangdong Provincial People's Hospital
2022
Chinese University of Hong Kong
2022
University of Pittsburgh Medical Center
2021
Acupuncture needle manipulation gives rise to "needle grasp," a biomechanical phenomenon characterized by an increase in the force necessary pull out of tissue (pullout force). This study investigates hypothesis that winding connective tissue, rather than muscle contraction, is mechanism responsible for grasp. We performed 1) measurements pullout humans with and without penetration muscle; 2) anesthetized rats, rotation, followed volume surrounding needle; 3) imaging rat abdominal wall...
Relaxation models fail to predict and explain loss characteristics of many viscoelastic materials which follow a frequency power law. A model based on time-domain statement causality is presented that describes observed power-law behavior materials. Hooke's law derived from characteristics; it reduces the for Voigt specific case quadratic loss. Broadband velocity data both longitudinal shear elastic types waves agree well with predictions. These acoustic are compared theories mechanisms in...
Although the connective tissues forming fascial planes of back have been hypothesized to play a role in pathogenesis chronic low pain (LBP), there no previous studies quantitatively evaluating tissue structure this condition. The goal study was perform an ultrasound-based comparison perimuscular lumbar region group human subjects with or recurrent LBP for more than 12 months, compared without LBP. In each 107 (60 and 47 LBP), parasagittal ultrasound images were acquired bilaterally centered...
Sonoporation is a targeted drug delivery technique that employs cavitation microbubbles to generate transient pores in the cell membrane, allowing foreign substances enter cells by passing through pores. Due broad size distribution of microbubbles, events appear be random process, making it difficult achieve controllable and efficient sonoporation. In this work reported using microfluidic device enables parallel modulation membrane permeability an oscillating microbubble array....
Abstract Sonodynamic therapy (SDT) has become a new modality for cancer through activating certain chemical sensitizers by ultrasound (US). Discovery and development of novel sonosensitizers are attracting extensive attentions. Here, we introduce IR-780 iodide, lipophilic heptamethine dye with peak optical absorption 780 nm wavelength, which can function as SDT agents breast treatment. The in vitro cellular uptake, cell viability the generation levels reactive oxygen species (ROS) were...
Cardiomyocyte death induced by ischemia–reperfusion is a major cause of morbidity and mortality worldwide. Hydrogen (H2), as an antioxidant, has been shown to have great potential in preventive therapeutic applications against lethal injury that occurs from ischemia–reperfusion. However, H2 sparingly soluble water, resulting its poor bioavailability blood damaged tissues. Here, we developed ultrasound–visible delivery system loading inside microbubbles (H2-MBs) prevent myocardial injury....
Broadly speaking, acoustic streaming is generated by a nonlinear wave with finite amplitude propagating in viscid fluid. The fluid volume elements of molecules, d V , are forced to oscillate at the same frequency as incident wave. Due nature nonlinearity wave, second-order effect propagation produces time-independent flow velocity (DC flow) addition regular oscillatory motion (AC motion). Consequently, moves certain direction, which depends on geometry system and its boundary conditions,...
The enhancement of ultrasound-induced cell destruction, lysis, and sonoporation in low concentration suspensions (2×105/mL) by the presence contrast agents (gas bubble to ratio=230) was demonstrated using cervical cancer cells (HeLa S3) containing micron-size denatured albumin microspheres filled with air (Albunex®) or octafluoropropane (Optison™). were insonificated 2-MHz continuous tone burst ultrasound near field. spatial peak-pressure amplitude 0.2 MPa. destruction due Optison™ shown be...
Reparable sonoporation was observed in Jurkat lymphocytes suspension exposed to a vibrating Mason horn tuned 21.4 KHz. The diameter of the tip 400 microm and its transverse displacement amplitude 7.8 microm. It found that shear stress associated with microstreaming surrounding Mason-horn primary reason for cell reparable sonoporation. threshold determined be 12 +/- 4 Pa exposure time up 7 min. also shorter time, greater threshold.
The continued examination of potential biological effects ultrasound and their relationship to clinical practice is a key element in evaluating the safety diagnostic ultrasound. Periodically, American Institute Ultrasound Medicine (AIUM) sponsors conferences bringing experts together examine literature on bioeffects develop conclusions recommendations related most recent effort included whose origins were thermal or nonthermal, with separate evaluations for fetal In addition, due...
Abstract Background Acupuncture points and meridians are commonly believed to possess unique electrical properties. The experimental support for this claim is limited given the technical methodological shortcomings of prior studies. Recent studies indicate a correspondence between acupuncture connective tissue planes. We hypothesized that segments associated with loose planes (between muscles or muscle bone) visible by ultrasound have greater conductance (less impedance) than non-meridian,...
A general expression for the acoustic radiation force on a small compressible sphere has been derived and expressed in terms of time-averaged densities Ti Vi kinetic potential energies, respectively, incident sound field. The results have applied to two focused beams: Gaussian beams piston beams. For both cases, analytical expressions forces placed axis are calculated. pertinent applications levitation bubble dynamics discussed.
A microfluidic device was developed to precisely transport a single cell or multiple microbubbles by introducing phase-shifts standing leaky surface acoustic wave (SLSAW). The consists of polydimethyl-siloxane (PDMS) microchannel and two phase-tunable interdigital transducers (IDTs) for the generation relative phase pair waves (SAW) propagating along opposite directions forming wave. When SAW contacts fluid medium inside microchannel, some energy is coupled becomes By modulating between...
The highly localized, periodic force induced by resonant transmission of acoustic waves via a phononic crystal is capable trapping, aligning, sorting, and transferring large numbers particles according to size or density, all in tunable scalable manner. This approach exploits flexural mode unavailable conventional optical techniques, using an engineered field raise power from the 10% predicted classical theory 60%. advance has implications for cell additive materials fabrication, targeted...