A5100433471- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Bone Tissue Engineering Materials
- Characterization and Applications of Magnetic Nanoparticles
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- Nanocluster Synthesis and Applications
- Electrochemical sensors and biosensors
- T-cell and B-cell Immunology
- Ultrasound and Hyperthermia Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Advanced Biosensing Techniques and Applications
- Parvovirus B19 Infection Studies
- Artificial Immune Systems Applications
- Microfluidic and Bio-sensing Technologies
- Concrete and Cement Materials Research
State Key Laboratory of Digital Medical Engineering
2016-2025
Southeast University
2016-2025
Nanjing Drum Tower Hospital
2025
Nanjing University of Chinese Medicine
2025
Zhongda Hospital Southeast University
2024-2025
Dalian Medical University
2022-2025
Wuhan Institute of Technology
2025
Quzhou University
2025
Zunyi Medical University
2022-2025
Kunming Institute of Botany
2024-2025
The generation of reactive oxygen species (ROS) is an important mechanism nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics inhibit •OH generation. theorized for first time activities likely caused by abundant redox...
Co3O4 nanoparticles (Co3O4 NPs), synthesized by the coprecipitation method, showed intrinsic catalase-like, peroxidase-like, and SOD-like activity. The catalytic activity of NPs was much higher than analogous Fe3O4 NPs. Co3O4's mechanisms were analyzed in detail using electron spin resonance (ESR) which confirmed that don't follow classical Fenton reactions with hydrogen peroxide way do. high redox potential Co3+/Co2+ supposed to be leading cause differences both mechanism Fe3O4. Based on...
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A novel nanofibrous composite scaffold composed of super-paramagnetic γ-Fe2O3 nanoparticles (MNP), hydroxyapatite (nHA) and poly lactide acid (PLA) was prepared using electrospinning technique. The well responds extern static magnetic field with typical saturation magnetization value 0.049 emu/g as possesses architecture. scaffolds were implanted in white rabbit model lumbar transverse defects. Permanent magnets are fixed the cages to provide for rabbits post surgery. Results show that MNP...
Nanoparticle-mediated tumor magnetic induction hyperthermia has received tremendous attention. However, it been a challenge to improve the efficacy at 42 °C therapeutic temperatures without resistance induced thermal stress. Therefore, we designed hydrogel nanozyme (MHZ) utilizing inclusion complexation between PEGylated nanoparticles and α-cyclodextrin, which can enhance oxidative stress levels by generating reactive oxygen species through nanozyme-catalyzed reactions based on hyperthermia....
Immunotherapy has had a profound positive effect on certain types of cancer but not improved the outcomes glioma because blood–brain barrier (BBB) and immunosuppressive tumor microenvironment. In this study, we developed an activated mature dendritic cell membrane (aDCM)-coated nanoplatform, rapamycin (RAPA)-loaded poly(lactic-co-glycolic acid) (PLGA), named aDCM@PLGA/RAPA, which is simple, efficient, individualized strategy to cross BBB improve immune microenvironment precisely. vitro cells...
Abstract Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate with structures reconstruct the microenvironment fulfill satisfying repair effects. In this review article, we first discuss various strategies design construction of promote defect repair, especially including structural scaffold integration bioactive substances together application external stimuli....
Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory response hinders diabetic wounds from healing. It leads to the accumulation of large amounts reactive oxygen species (ROS) therefore prevents transition phase proliferative phase. In this work, a nanohybrid double network hydrogel injectable, self-healing, tissue adhesion properties based on platinum nanozyme composite (PFOB@PLGA@Pt) was constructed manage wound PFOB@PLGA@Pt exhibited supply capacity...
Persistent inflammation within atherosclerotic plaques is a crucial factor contributing to plaque vulnerability and rupture. It has become increasingly evident that the proinflammatory microenvironment of plaque, characterized by heightened monocyte recruitment, oxidative stress, impaired clearance apoptotic cells, plays significant role in perpetuating impeding its resolution. Consequently, targeting eliminating these features have emerged as promising therapeutic approach restore...
Abstract The rational integration of chemotherapy and hydroxyl radical (·OH)‐mediated chemodynamic therapy (CDT) holds great potential for cancer treatment. Herein, a smart biocompatible nanocatalyst based on porous core–shell cuprous oxide nanocrystals (Cu 2 O‐PEG (polyethylene glycol) NCs) is reported acid‐triggered chemo/chemodynamic synergistic therapy. in situ formed high density hydrophilic PEG outside greatly improves the stability compatibility NCs. porosity Cu NCs shows admirable...
Photodynamic therapy (PDT) as a noninvasive mode has attracted considerable attention in the field of oncotherapy. However, PDT efficacy is restricted either by tumor hypoxia environment or inherent properties photosensitizers (PSs) including bad water solution, photobleaching, and easy aggregation. Herein, we designed synthesized new two-dimensional (2D) metal–organic framework, Sm-tetrakis(4-carboxyphenyl)porphyrin (TCPP) nanosheets, assembling transition metal ions (Sm3+) PSs (TCPP), on...
Performance of nanoprobes can often determine the detection level Lateral immunochromatography. Traditional probes were limited by quantity and orientation antibodies, immune activity Fab region or binding strength between protein substrate. This study developed a new efficient robust technology to construct fluorescent with oriented modified based on specific Fc antibody streptococcal G (SPG) surface polystyrene microspheres (MS) subsequent covalent cross-linking at sites firm them. flow...
Earlier reports of fabricating 3D porous PCL scaffolds for tissue engineering applications were overshadowed by several limitations such as additional molds cost, relatively low efficiency, and lacking process control. In present study, combined extrusion-based cryogenic printing (ECP) (−20 °C) subsequent freeze-drying approaches employed to facilely fabricate polycaprolactone (PCL) scaffolds, with high porosity fidelity. Freeze-drying caused shrinkage the along X, Y, Z-axes some extent. The...
Cetuximab (C225) is a unique agent, targeting epidermal growth factor receptor (EGFR)-positive cancer. However, the therapeutic effect of C225 in EGFR high-expressing non-small cell lung cancer (NSCLC) remains poor. Here, we report that conjugation with gold nanoparticles (AuNPs) enhances cytotoxicity NSCLC both vitro and vivo. The lines A549 (EGFRhigh) H1299 (EGFRlow) were employed to investigate different responses C225, IgG-AuNPs C225-AuNPs. antitumor properties C225-AuNPs explored vivo...