Christy K. Holland

ORCID: 0000-0003-3382-7170
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About
Contact & Profiles
Research Areas
  • Ultrasound and Hyperthermia Applications
  • Photoacoustic and Ultrasonic Imaging
  • Ultrasound and Cavitation Phenomena
  • Ultrasound Imaging and Elastography
  • Venous Thromboembolism Diagnosis and Management
  • Acute Ischemic Stroke Management
  • Coronary Interventions and Diagnostics
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Ultrasound in Clinical Applications
  • Ultrasonics and Acoustic Wave Propagation
  • Peripheral Artery Disease Management
  • Diagnosis and Treatment of Venous Diseases
  • Cerebrovascular and Carotid Artery Diseases
  • Marriage and Sexual Relationships
  • Blood Coagulation and Thrombosis Mechanisms
  • Nanoparticle-Based Drug Delivery
  • Microfluidic and Bio-sensing Technologies
  • Advanced MRI Techniques and Applications
  • Academic Writing and Publishing
  • Anesthesia and Neurotoxicity Research
  • Central Venous Catheters and Hemodialysis
  • Infective Endocarditis Diagnosis and Management
  • Electrospun Nanofibers in Biomedical Applications
  • Orthopedic Infections and Treatments
  • Cardiovascular Health and Disease Prevention

University of Cincinnati
2016-2025

Sabin Vaccine Institute
2008-2023

The University of Texas Health Science Center at Houston
2010-2023

RELX Group (United States)
2018-2022

American Institute of Ultrasound in Medicine
2018-2022

Boston Scientific (United States)
2022

RELX Group (United Kingdom)
2018-2022

Inserm
2021

University of Cincinnati Medical Center
1996-2016

Walsall Manor Hospital
2013

Transient cavitation is a discrete phenomenon that relies on the existence of stabilized nuclei, or pockets gas within host fluid, for its genesis. A convenient descriptor assessing likelihood transient threshold pressure, minimum acoustic pressure necessary to initiate bubble growth and subsequent collapse. An automated experimental apparatus has been developed determine thresholds produced in fluid by short tone bursts ultrasound at 0.76, 0.99, 2.30 MHz. jet was used convect potential...

10.1121/1.400102 article EN The Journal of the Acoustical Society of America 1990-11-01

An approximate analytical formulation is presented that allows for the calculation of acoustic pressure thresholds transient cavitation over a variety frequencies and host fluid parameters. Specifically, R.E. Apfel's (1986) theory extended to include an estimate time delay associated with Laplace pressure, 2sigma/R(0), where sigma surface tension R(0) initial radius. Also correction factor time-averaged difference, across bubble wall during growth. optimum size distribution nuclei...

10.1109/58.19152 article EN IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 1989-03-01

A method is presented for passive imaging of cavitational acoustic emissions using an ultrasound array, with potential application in real-time monitoring ablation. To create such images, microbubble were passively sensed by array and dynamically focused at multiple depths. In this paper, analytic expression a image obtained solving the Rayleigh–Sommerfield integral, under Fresnel approximation, images simulated. 192-element was used to real time, from 520-kHz scattered 1-mm steel wire....

10.1121/1.3238260 article EN The Journal of the Acoustical Society of America 2009-12-01

Speakers of rhotic dialects North American English show a range different tongue configurations for /r/. These variants produce acoustic profiles that are indistinguishable the first three formants [Delattre, P., and Freeman, D. C., (1968). “A dialect study r’s by x-ray motion picture,” Linguistics 44, 28–69; Westbury, J. R. et al. (1998), “Differences among speakers in lingual articulation /r/,” Speech Commun. 26, 203–206]. It is puzzling why this should be so, given very vocal tract...

10.1121/1.2902168 article EN The Journal of the Acoustical Society of America 2008-06-01

Passive cavitation detection has been an instrumental technique for measuring dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently, techniques have developed to create images of activity provide investigators with a more complete set information. These use arrays record subsequently beamform received emissions, rather than processing emissions on single-element transducer. In this paper, the methods performing frequency-domain delay, sum, integrate passive...

10.1109/tuffc.2016.2620492 article EN IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2016-10-25

Previously, passive cavitation imaging has been described in the context of continuous-wave high-intensity focused ultrasound thermal ablation. However, technique potential use as a feedback mechanism for pulsed-wave therapies, such ultrasound-mediated drug delivery. In this paper, results experiments and simulations are reported to demonstrate feasibility using pulsed insonations how images depend on parameters. The were formed from channel data that was beamformed frequency domain....

10.1121/1.4728230 article EN The Journal of the Acoustical Society of America 2012-07-01

The mechanical index (MI) was formulated to gauge the likelihood of adverse bioeffects from inertial cavitation. However, MI formulation did not consider bubble activity stable This type can be readily nucleated ultrasound contrast agents (UCAs) and has potential promote beneficial bioeffects. Here, presence cavitation is determined numerically by tracking onset subharmonic oscillations within a population bubbles for frequencies up 7 MHz peak rarefactional pressures 3 MPa. In addition,...

10.1088/0031-9155/58/1/127 article EN Physics in Medicine and Biology 2012-12-07

Recent increases in the pressure output of diagnostic ultrasound scanners have led to an interest establishing thresholds for bioeffects many organs including lungs mammals. Damage may be mediated by inertial cavitation, yet there been no such direct observations vivo. To explore hypothesis cavitation-based from ultrasound, research has performed on damage rat exposed 4.0-MHz pulsed Doppler and color ultrasound. A 30-MHz active cavitation detection scheme complementing these studies provides...

10.1016/0301-5629(96)00083-x article EN cc-by-nc-nd Ultrasound in Medicine & Biology 1996-01-01

The continued examination of potential biological effects ultrasound and their relationship to clinical practice is a key element in evaluating the safety diagnostic ultrasound. Periodically, American Institute Ultrasound Medicine (AIUM) sponsors conferences bringing experts together examine literature on bioeffects develop conclusions recommendations related most recent effort included whose origins were thermal or nonthermal, with separate evaluations for fetal In addition, due...

10.7863/jum.2008.27.4.503 article EN Journal of Ultrasound in Medicine 2008-04-01

Background. Haemodialysis vascular access dysfunction is currently a huge clinical problem. Although arteriovenous (AV) fistulae are the preferred mode of dialysis access, they have significant problems with both early (failure to mature) and late fistula failure. Both characterized radiologically as stenosis venous segment. Despite magnitude problem, exact pathogenesis AV failure remains unclear. The aim this study was develop validate pig model then use it dissect out mechanisms...

10.1093/ndt/gfm547 article EN Nephrology Dialysis Transplantation 2007-10-30
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