A5044516742- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Nanoplatforms for cancer theranostics
- Ultrasound and Cavitation Phenomena
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Extracellular vesicles in disease
- Microfluidic and Capillary Electrophoresis Applications
- Vagus Nerve Stimulation Research
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Health and Disease Prevention
- Acoustic Wave Resonator Technologies
- Tissue Engineering and Regenerative Medicine
- Fluid Dynamics and Mixing
- MicroRNA in disease regulation
- Minerals Flotation and Separation Techniques
- Cardiovascular Function and Risk Factors
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Signaling Pathways in Disease
Huazhong University of Science and Technology
2019-2025
Union Hospital
2019-2025
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2020-2025
Union Hospital
2020-2025
National Tsing Hua University
2016-2019
Shenzhen Institutes of Advanced Technology
2010-2017
Chinese Academy of Sciences
2009-2015
Drexel University
2014
Shenzhen University
2012
Academia Sinica
2012
Cardiomyocyte death induced by ischemia–reperfusion is a major cause of morbidity and mortality worldwide. Hydrogen (H2), as an antioxidant, has been shown to have great potential in preventive therapeutic applications against lethal injury that occurs from ischemia–reperfusion. However, H2 sparingly soluble water, resulting its poor bioavailability blood damaged tissues. Here, we developed ultrasound–visible delivery system loading inside microbubbles (H2-MBs) prevent myocardial injury....
Abstract Electroceuticals, through the selective modulation of peripheral nerves near target organs, are promising for treating refractory diseases. However, small sizes and delicate nature these present challenges in simplifying fixation stabilizing electrical-coupling interface neural electrodes. Herein, we construct a robust fine using an injectable bio-adhesive hydrogel bioelectronics. By incorporating multifunctional molecular regulator during network formation, optimize injectability...
A microfluidic device was developed to precisely transport a single cell or multiple microbubbles by introducing phase-shifts standing leaky surface acoustic wave (SLSAW). The consists of polydimethyl-siloxane (PDMS) microchannel and two phase-tunable interdigital transducers (IDTs) for the generation relative phase pair waves (SAW) propagating along opposite directions forming wave. When SAW contacts fluid medium inside microchannel, some energy is coupled becomes By modulating between...
Myocardial ischemia/reperfusion injury (MIRI) is the leading cause of irreversible myocardial damage. A pivotal pathogenic factor (I/R)-induced cardiomyocyte ferroptosis, marked by iron overload and lipid peroxidation. However, impact droplet (LD) changes on I/R-induced ferroptosis unclear. In this study, an aggregation-induced emission probe, TPABTBP developed that used for imaging dynamic in LD during ferroptosis. exhibits excellent LD-specificity, superior capability monitoring lipophagy,...
Targeted and controlled nitric oxide (NO) release is critical due to an extremely short half life low bioavailability for treating cardiovascular diseases. To address this challenge, various sustained‐release precursors NO donors activated by light, enzyme, or pH are developed. However, their efficacy limited the deep location rapid blood flow of heart. Herein, a platelet membrane‐coated nanoparticle (B‐P@PLT) designed with polymeric core loaded BNN6, ultrasound‐responsive donor, targeted...
Nanoscale gas bubbles residing on a macroscale hydrophobic surface have surprising long lifetime (on the order of days) and can serve as cavitation nuclei for initiating inertial (IC). Whether interfacial nanobubbles (NBs) reside infinite nanoparticle (NP) could is unknown, but this would be very meaningful development sonosensitive NPs. To address problem, we investigated IC activity polytetrafluoroethylene (PTFE) NPs, which are regarded benchmark superhydrophobic NPs due to their low...
Abstract Background Cancer stem cells (CSCs) are crucial for the growth, metastasis, drug resistance, recurrence, and spread of tumors. Napabucasin (NAP) could effectively inhibit CSC, but its mechanism has not been fully explained. Additionally, NAP also drawbacks poor water solubility low utilization. Therefore, this study only elaborated new inhibiting CSCs, built NAP-loaded nanoprobes using apoptotic tumor-derived microparticles (TMPs) as carriers to combine diagnose treat colon cancer...
This paper presents a new algorithm for ultrasonic particle image velocimetry (Echo PIV) improving the flow velocity measurement accuracy and efficiency in regions with high gradients. The conventional Echo PIV has been modified by incorporating multiple iterative algorithm, sub-pixel method, filter interpolation spurious vector elimination algorithm. algorithms' performance is assessed analyzing simulated images known displacements, B-mode of vitro laminar pipe flow, rotational vivo rat...
Ultrasound-targeted microbubble destruction (UTMD) is a promising approach to facilitate the precise delivery of bone marrow stem cells (BMSCs) ischemic myocardium. However, cell therapy for myocardium challenging due poor survival transplanted under severe conditions. In this study, we investigated whether myocardium-targeted transplantation prolyl hydroxylase domain protein 2 (PHD2) shRNA-modified BMSCs by UTMD increases viability grafted cells, and enhances their cardioprotective effects...
Background: Oxidative stress is crucial in experimental autoimmune myocarditis (EAM)-induced inflammatory myocardial injury. Ursolic acid (UA) an antioxidant-enriched traditional Chinese medicine formula. The present study aimed to investigate whether UA could alleviate cardiac injury and determine the underlying mechanisms. Methods: Six-week-old male BALB/c mice were randomly assigned one of three groups: Sham, EAM group, or intervention group (UA group) by gavage for 2 weeks. An model was...
A novel cationic microbubble (MB) for improvement of the DNA loading capacity and ultrasound-mediated gene delivery efficiency has been developed; it prepared with commercial lipids a stearic acid modified polyethylenimine 600 (Stearic-PEI600) polymer synthesized via acylation reaction branched PEI600 mediated by N, N'-carbonyldiimidazole (CDI). The MBs' concentration, size distribution, stability zeta potential (ζ-potential) were measured was examined as function amount Stearic-PEI600....