A5100622592- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Advanced Glycation End Products research
- Spondyloarthritis Studies and Treatments
- Cardiovascular Disease and Adiposity
- Immune Response and Inflammation
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- IgG4-Related and Inflammatory Diseases
- Genetic and phenotypic traits in livestock
- Cardiac Structural Anomalies and Repair
- Gastrointestinal disorders and treatments
- Cardiovascular Effects of Exercise
- Fatty Acid Research and Health
- Neuroendocrine Tumor Research Advances
- Berberine and alkaloids research
- Barrier Structure and Function Studies
- Viral Infections and Immunology Research
- Alcohol Consumption and Health Effects
- Digestive system and related health
- Advanced MRI Techniques and Applications
- Endometriosis Research and Treatment
Union Hospital
2013-2024
Huazhong University of Science and Technology
2013-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2020-2024
Union Hospital
2021-2024
Biotechnology Research Institute
2024
Central Hospital of Wuhan
2014-2019
Infinitus (China)
2014
Tongji Hospital
2013
Kanazawa Medical University
2013
Henan University of Traditional Chinese Medicine
2009
Background: RVEF (right ventricular ejection fraction) measured by three-dimensional echocardiography (3DE) has been used in evaluating right (RV) function and can provide useful prognostic information other various cardiovascular diseases. However, the value of 3D-RVEF coronavirus disease 2019 (COVID-19) remains unknown. We aimed to investigate whether predict mortality COVID-19 patients. Methods: A cohort 128 COVID-19-confirmed patients who had undergone were studied. Thirty-one healthy...
Tight Junctions (TJ) are important components of paracellular pathways, and their destruction enhances vascular permeability. Resolvin D1 (RvD1) is a novel lipid mediator that has treatment effects on inflammatory diseases, but its effect inflammation induced increase in permeability unclear. To understand whether RvD1 counteracts the lipopolysaccharide (LPS) cell permeability, we investigated endothelial barrier tight junction reorganization expression presence or absence LPS stimulation...
Elevated serum IgG4 levels are an important hallmark for diagnosing IgG4-related disease (IgG4-RD), but can also be observed in other diseases. This study aimed to compare two different testing methods IgG4: ELISA and nephelometric assay. Both assays were used measure concentrations, assess the prevalence of high both IgG4-RD non-IgG4-RD diseases.A total 80 samples tested using assay method that we established. Serum concentrations determined by 957 patients with distinct diseases, including...
This study aimed to investigate the effect of long non-coding RNA nuclear enriched abundant transcript 1 (lnc-NEAT1) on cell proliferation and apoptosis in myocardial ischemia/reperfusion (I/R) injury cells, explore its target miRNAs. H9c2 cells were cultured oxygen glucose deprivation followed by reperfusion (OGD/R) condition construct a I/R model. Blank shRNA lnc-NEAT1 transferred into normal as Normal&sh-NC, OGD/R&sh-NC OGD/R&sh-NEAT1 groups. Rescue experiment was performed transfection...
Background. Human leukocyte antigen (HLA)-G, a nonclassical HLA class I molecule, induces wide range of tolerogenic immunological effects by means interaction with its inhibitory receptors. However, recent studies show that HLA-G dimer formation is essential to bind receptors and exhibit effects. Methods. In this study, soluble divalent HLA-G/IgG molecule (sHLA-G dimer) was constructed. Its effect on T-cell alloresponse studied mixed lymphocyte reaction in vitro, which set up mixing...
Background Whether the combination of ventricular strain with high-sensitivity troponin I (hs-TNI) has an incremental prognostic value in coronavirus disease 2019 (COVID-19) patients not been evaluated. The study aimed to evaluate biventricular longitudinal and its hs-TNI COVID-19 patients. Methods A total 160 who underwent both echocardiography testing were enrolled our study. divided into two groups (critical non-critical) according severity-of-illness. clinical characteristics, cardiac...
Objective . High mobility group box 1 (HMGB1) is a late inflammatory factor participating in the pathogenesis of various autoimmune and diseases. In current study, we analyzed association between serum levels HMGB1 clinical features AS patients before during treatment. Methods Serum was detected 147 61 healthy controls using ELISA. We evaluated extra-articular manifestations as well disease severity indices. Among these patients, 41 received close follow-up at 1, 3, 6 months after This...
Abstract Background Due to insufficient near‐field resolution and artifacts, it is challenging evaluate the left ventricular apical perfusion with phased‐array probes. By combining high‐frequency linear probe contrast‐enhanced ultrasound (CEUS), imaging of myocardial could be improved. The study aims preliminary application CEUS by probes assess perfusion. Methods enrolled retrospectively 91 patients test feasibility novel method. In protocol 1, were stratified into a group anterior...
Soluble CD30 (sCD30), a transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily, has been shown be associated with various pathological conditions. This study was designed measure levels of serum sCD30 in patients ankylosing spondylitis (AS) and evaluate relationships between other disease severity-related indexes, including bath activity index (BASDAI), score (ASDAS), functional (BASFI). Our results demonstrated significantly elevated AS compared...
The aims of our study were (1) to assess the right ventricular (RV) myocardial mechanics by two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography (STE) in patients with an ischemic or non-ischemic etiology end-stage heart failure (HF) (2) explore which RV index evaluated 2D- 3D-STE was most powerful indicator for identifying etiologies HF.A total 96 left ejection fraction (LVEF) < 30% enrolled study: 42 (mean age, 52 ± 10 years; 9.5% female) cardiomyopathy 54 46...
Objective: This study aimed to: (1) evaluate the association between myocardial fibrosis (MF) quantified by extracellular volume fraction (ECV) and strain measured two-dimensional (2D)- three-dimensional speckle-tracking echocardiography (3D-STE) (2) further investigate which parameter 2D- 3D-STE is more robust predictor of MF in heart transplant (HT) recipients. Methods: A total 40 patients with HT 20 healthy controls were prospectively enrolled. Left ventricular (LV)-global longitudinal...
Genome selection (GS) technology is an important means to improve the genetic improvement of dairy cows, and mining application functional genes loci for traits one bases accelerating improvement. Our previous study found that apolipoprotein A5 (APOA5) AKT serine/threonine kinase 3 (AKT3) were differentially expressed in liver tissue Chinese Holstein cows at different lactation stages influenced milk component synthesis metabolism, so we considered these two as candidates affecting...