A5100433737- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Polysaccharides and Plant Cell Walls
- Sulfur Compounds in Biology
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Molecular Sensors and Ion Detection
- Traditional Chinese Medicine Studies
- Erythrocyte Function and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Chronic Lymphocytic Leukemia Research
- Metabolism and Genetic Disorders
- Metabolism, Diabetes, and Cancer
- Iron Metabolism and Disorders
- Amino Acid Enzymes and Metabolism
- Folate and B Vitamins Research
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
Huazhong University of Science and Technology
2016-2025
Shanghai Ninth People's Hospital
2023-2025
Shanghai Jiao Tong University
2007-2025
China Jiliang University
2025
Sir Run Run Shaw Hospital
2025
Harbin Medical University
2014-2025
Second Affiliated Hospital of Harbin Medical University
2014-2025
Wuhan National Laboratory for Optoelectronics
2009-2025
Nanjing Tech University
2025
Union Hospital
2015-2024
OBJECTIVE Diabetes is one of the most distinct comorbidities COVID-19. Here, we describe clinical characteristics and outcomes in patients with diabetes whom COVID-19 was confirmed or clinically diagnosed (with typical features on lung imaging symptoms) their association glucose-lowering blood pressure–lowering medications. RESEARCH DESIGN AND METHODS In this retrospective study involving 904 (136 diabetes, mostly type 2 diabetes), laboratory were collected compared between group without...
Antibacterial metal ions, such as Ag+, Zn2+ and Cu2+, have been extensively used in medical implants devices due to their strong broad spectrum of antibacterial activity. However, it is still a controversial issue whether they can show the desired activity while being toxic mammalian cells. It very important balance effectiveness with minimal damage Toward this end, study identify suitable concentrations these three ions at which effectively kill two types clinically relevant bacteria...
Abstract Oxidative stress-related apoptosis and autophagy play crucial roles in the development of osteoarthritis (OA), a progressive cartilage degenerative disease with multifactorial etiologies. Here, we determined autophagic flux changes human OA tert-Butyl hydroperoxide (TBHP)-treated chondrocytes. In addition, explored potential protective effects trehalose, novel Mammalian Target Rapamycin (mTOR)-independent inducer, TBHP-treated mouse chondrocytes destabilized medial meniscus (DMM)...
Abstract Background A considerable proportion of patients hospitalized with coronavirus disease 2019 (COVID-19) acquired secondary bacterial infections (SBIs). The etiology and antimicrobial resistance bacteria were reported used to provide a theoretical basis for appropriate infection therapy. Methods This retrospective study reviewed electronic medical records all the COVID-19 in Wuhan Union Hospital between January 27 March 17, 2020. According inclusion exclusion criteria, who SBIs...
Cells adapt to nutrient and energy deprivation by inducing autophagy, which is regulated the mammalian target of rapamycin (mTOR) AMP-activated protein kinases (AMPKs). We found that cell metabolism significantly influences ability induce with mitochondrial complex I function being an important factor in initiation, amplitude, duration response. show phenformin or genetic defects suppressed autophagy induced mTOR inhibitors, whereas was enhanced strategies increased metabolism. report...
Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as negative feedback regulator TNFα-triggered NF-κB intracellularly. Inflammatory stimuli induce ANGPTL8 expression, and knockdown or knockout of potentiates TNFα-induced vitro. Mechanistically, upon TNFα stimulation, facilitates the interaction IKKγ with p62 via forming complex, thus promoting...
Summary Background On March 11, 2020, the World Health Organization declared its assessment of COVID-19 as a global pandemic. However, specific antiviral drugs are still unavailable, and pateints managed by multiple complementary treatments. Methods The electronic medical records patients where basic information, complete blood count, coagulation profile, inflammatory cytokines serum biochemical indicators in 42 with (21 whom were treated low molecular weight heparin (LMWH), 21 without LMWH)...
IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which ubiquitously expressed a variety cells. Although it has been demonstrated that can provoke multiple cellular processes during viral infection, including type I interferon (IFN) production, mechanisms underlying precise regulation activity are still not completely understood. Here, we report selective macroautophagy/autophagy mediated by cargo receptor...
Abstract The coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 infection can lead to a series of clinical settings from non-symptomatic viral carriers/spreaders severe illness characterized acute respiratory distress syndrome (ARDS)1,2. A sizable part patients with COVID-19 have mild symptoms at the early stage infection, but disease progression may become quite rapid in later ARDS as common manifestation and followed critical multiple organ failure, causing high mortality rate 7-10%...