A5101845017- Autophagy in Disease and Therapy
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Ubiquitin and proteasome pathways
- Shoulder Injury and Treatment
- Immune Response and Inflammation
- Inflammasome and immune disorders
- RNA modifications and cancer
- Knee injuries and reconstruction techniques
- RNA Research and Splicing
- Shoulder and Clavicle Injuries
- Viral-associated cancers and disorders
- Viral Infections and Immunology Research
- RNA and protein synthesis mechanisms
- Vector-Borne Animal Diseases
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Plant Virus Research Studies
Second Affiliated Hospital of Jilin University
2024-2025
State Key Laboratory of Respiratory Disease
2020-2024
Guangzhou Medical University
2012-2024
University College London
2024
China Pharmaceutical University
2023
Sun Yat-sen University
2016-2023
Guangzhou Women and Children Medical Center
2019-2022
First Affiliated Hospital of Guangzhou Medical University
2021-2022
Fudan University
2022
Qingdao University
2017
Abstract Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes. Accumulation of these chemicals has adverse effects on human health, including inflammation multiple organs, yet how PFAS sensed by host cells, and tissue eventually incurs, is still unclear. Here, we show that the double-stranded DNA receptor AIM2 able to recognize perfluorooctane sulfonate (PFOS), a common form PFAS, trigger IL-1β secretion pyroptosis. Mechanistically, PFOS activates inflammasome...
Abstract The ongoing 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 has posed a worldwide pandemic and major global public health threat. severity mortality of COVID-19 are associated with virus-induced dysfunctional inflammatory responses cytokine storms. However, the interplay between host infection remains largely unknown. Here, we demonstrate that nucleocapsid (N) protein, structural protein virion, promotes virus-triggered activation NF-κB signaling. After binding to...
Abstract Rare genetic variants in toll-like receptor 7 (TLR7) are known to cause lupus humans and mice. UNC93B1 is a transmembrane protein that regulates TLR7 localization into endosomes. In the present study, we identify two new (T314A, located proximally domain, V117L) cohort of east Asian patients with childhood-onset systemic erythematosus. The V117L variant was associated increased expression type I interferons NF-κB-dependent cytokines patient plasma immortalized B cells. THP-1 cells...
The murine monoclonal antibody mAb-1H11 raised against malondialdehyde (MDA)-modified LDL, was used to detect cross-reacting material in human atheromatous tissue and plasma. MDA-modified LDL levels plasma were 0.19 +/- 0.02 mg/dl (mean SEM) 44 control subjects, 0.24 15 patients with chronic stable angina pectoris (P = NS vs cholesterol matched controls), 1.4 0.1 60 acute myocardial infarction < 0.001 0.86 0.11 22 carotid atherosclerosis controls). Modified isolated from pooled of 10...
ABSTRACT Respiratory disease caused by the 2019 novel coronavirus (2019-nCoV) pneumonia first emerged in Wuhan, Hubei Province, China, December and spread rapidly to other provinces countries. Angiotensin-converting enzyme 2 (ACE2) is receptor for SARS-CoV has been suggested be also 2019-nCoV. Paradoxically, ACE2 expression lung protects mice from spike protein induced injury attenuating renin-angiotensin system. In intestine, suppresses intestinal inflammation maintaining amino acid...
IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which ubiquitously expressed a variety cells. Although it has been demonstrated that can provoke multiple cellular processes during viral infection, including type I interferon (IFN) production, mechanisms underlying precise regulation activity are still not completely understood. Here, we report selective macroautophagy/autophagy mediated by cargo receptor...
In addition to investigating the virology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovering host-virus dependencies are essential identify and design effective antiviral therapy strategy. Here, we report that SARS-CoV-2 entry receptor, ACE2, conjugates with small ubiquitin-like modifier 3 (SUMO3) provide evidence indicating prevention ACE2 SUMOylation can block infection. E3 SUMO ligase PIAS4 prompts stabilization whereas deSUMOylation enzyme SENP3 reverses this...
Abstract The human coronavirus HCoV-19 infection can cause acute respiratory distress syndrome (ARDS), hypercoagulability, hypertension, extrapulmonary multiorgan dysfunction. Effective antiviral and anti-coagulation agents with safe clinical profiles are urgently needed to improve the overall prognosis. We screened an FDA approved drug library found that anticoagulant agent dipyridamole (DIP) suppressed replication at EC50 of 100 nM in vitro . It also elicited potent type I interferon...
Immunotherapy has greatly improved cancer treatment in recent years by harnessing the immune system to target cells. The first immunotherapeutic agent approved FDA was IFNα. Treatment with IFNα can lead effective activation and attenuate tumor evasion, but persistent been shown elicit immunosuppressive effects. Here, we identified an autophagy-dependent mechanism which triggers evasion upregulating PD-L1 suppress antitumor activity of CD8+ T Mechanistically, increased transcription TRIM14,...
Chromatin modifications, such as histone acetylation, ubiquitination, and methylation, play fundamental roles in maintaining chromatin architecture regulating gene transcription. Although their crosstalk remodeling has been gradually uncovered, the functional relationship between ubiquitination methylation immunity inflammation remains unclear. Here, it is reported that USP38 a novel deubiquitinase works together with H3K4 modifier KDM5B to orchestrate inflammatory responses. specifically...
Abstract The noncanonical NF‐κB signaling pathway plays a critical role in variety of biological functions including chronic inflammation and tumorigenesis. Activation largely relies on the abundance as well processing family member p100/p52. Here, TRIM14 is identified novel positive regulator pathway. promotes activation by targeting p100/p52 vitro vivo. Furthermore, mechanistic study shows that recruits deubiquitinase USP14 to cleave K63‐linked ubiquitin chains at multiple sites, thereby...
Autophagy is a fundamental cellular process of protein degradation and recycling that regulates immune signaling pathways via multiple mechanisms. However, it remains unclear how autophagy epigenetically the response. Here, we identified TRIM14 as an epigenetic regulator reduces histone H3K9 trimethylation by inhibiting autophagic demethylase KDM4D. recruited deubiquitinases USP14 BRCC3 to cleave K63-linked ubiquitin chains KDM4D, which prevented KDM4D from undergoing optineurin...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), has had a significant impact on healthcare systems and economies worldwide. The continuous emergence new viral strains presents major challenge in development effective antiviral agents. Strategies that possess broad-spectrum activities are desirable to control SARS-CoV-2 infection. ACE2, an angiotensin-containing enzyme prevents overactivation renin angiotensin system, is...
NF-κB signaling controls a large set of physiological processes ranging from inflammatory responses to cell death. Its activation is tightly regulated through controlling the activity and stability multiple components. Here, we identify that suppressed by an F-box protein, S-phase kinase associated protein 2 (SKP2). SKP2 deficiency enhanced as well production cytokines. In addition, potently blocked at IκB (IKK) level. Mechanistic study further revealed functions adaptor promote interaction...
Abstract Objectives Rare diseases are a global public health issue with more pressing situation in China. Unfortunately, the relevant research and development this country still its infancy, leading to limited drug accessibility. In view of this, Chinese government has taken series countermeasures promote orphan R&D recent years, which presented encouraging results. This paper aims review incentive policies funding initiatives formulated by examine their implications on R&D. Methods...
The intra-articular corticosteroid injection (IACI) and arthroscopic partial meniscectomy (APM) are crucial treatment options for meniscus tears widely used in clinical practice. To determine whether there differences the progression of osteoarthritis (OA) after APM IACI treatments degenerative meniscal tears, to identify influencing factors. We finally collected minimum joint space width (JSW), WOMAC score, KOOS score 189 patients 4 years follow-up. mixed effects model general estimating...