A5001929655- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Digital Imaging for Blood Diseases
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Bone and Joint Diseases
- Eosinophilic Disorders and Syndromes
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Retinoids in leukemia and cellular processes
- Hematological disorders and diagnostics
- Image Processing Techniques and Applications
- Circular RNAs in diseases
- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 and COVID-19 Research
- Ziziphus Jujuba Studies and Applications
- Extracellular vesicles in disease
- Drug Transport and Resistance Mechanisms
- Ion Channels and Receptors
- Blood properties and coagulation
- Natural Compound Pharmacology Studies
- Ginger and Zingiberaceae research
Wuhan University
2016-2025
Zhongnan Hospital of Wuhan University
2016-2025
Wuhan University of Technology
2011-2024
Shenzhen Academy of Inspection and Quarantine
2023
Jinan University
2022
Coney Island Hospital
2020-2021
University of Illinois Chicago
2019-2020
China Agricultural University
2020
University of Illinois Urbana-Champaign
2019
Illinois College
2019
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause distress syndrome, hypercoagulability, hypertension, and multiorgan dysfunction. Effective antivirals with safe clinical profile are urgently needed to improve the overall prognosis. In an analysis of a randomly collected cohort 124 patients COVID-19, we found that hypercoagulability as indicated by elevated concentrations D-dimers was associated disease severity. By virtual screening U.S. FDA approved drug...
Platelet-neutrophil interactions contribute to vascular occlusion and tissue damage in thromboinflammatory disease. Platelet glycoprotein Ibα (GPIbα), a key receptor for the cell-cell interaction, is believed be constitutively active ligand binding. Here, we established role of platelet-derived protein disulfide isomerase (PDI) reducing allosteric bonds GPIbα enhancing ligand-binding activity under conditions.Bioinformatic analysis identified 2 potential GPIbα. Agglutination assays, flow...
Abstract The human coronavirus HCoV-19 infection can cause acute respiratory distress syndrome (ARDS), hypercoagulability, hypertension, extrapulmonary multiorgan dysfunction. Effective antiviral and anti-coagulation agents with safe clinical profiles are urgently needed to improve the overall prognosis. We screened an FDA approved drug library found that anticoagulant agent dipyridamole (DIP) suppressed replication at EC50 of 100 nM in vitro . It also elicited potent type I interferon...
To address the concern of environmental pollution, it is necessary to study effect regulation on industrial solid waste emission reduction in China. This paper aimed analyze effectiveness provincial (both formal and informal) reduction. The results show that both informal regulations intensity present an inverted "U" shape. threshold value per capita GDP as indicator variable CNY 16,299 15,572 respectively. pollution will appear when higher than threshold, two-way transmission mechanism...
Abstract Bovine serum albumin, based on its low toxicity and excellent biocompatibility, has great potential as a carrier for drug delivery systems. In this context, pH/GSH dual‐responsive system (ICG/DOX@Fe‐BSA‐FA nanoparticles) albumin (BSA) is constructed tumor‐targeted multimodal therapy. study, doxorubicin (DOX) indocyanine green (ICG) are co‐loaded after Fe 3+ coordinated with BSA, the finally grafted targeted molecule Folic acid. DOX used in chemotherapy, ICG photodynamic therapy...
Platelet adhesion and aggregation play a crucial role in arterial thrombosis ischemic stroke. Here, we identify platelet ERO1α (endoplasmic reticulum oxidoreductase 1α) as novel regulator of Ca
Reactive lymphocytes are an important type of leukocytes, which morphologically transformed from lymphocytes. The increase in these cells is usually a sign certain virus infections, so their detection plays role the fight against diseases. Manual reactive undoubtedly time-consuming and labor-intensive, requiring high level professional knowledge. Therefore, it highly necessary to conduct research into computer-assisted diagnosis. With development deep learning technology field computer...
Moso bamboo is one of the economically most important plants in China. a monocarpic perennial that exhibits poor and slow germination. Thus, flowering often causes destruction moso forestry. However, how control seed germination are regulated largely unclear. In this study, we identified 5 members (PhFT1-5) phosphatidyl ethanolamine-binding proteins (PEBP) family from genome regulate flowering, flower architecture germination, characterized function these PEBP genes further Arabidopsis....
Reactive lymphocytes may indicate diseases such as viral infections. Identifying these abnormal is crucial for disease diagnosis. Currently, reactive are mainly manually identified by pathological experts with microscopes and morphological knowledge, which time-consuming laborious. Some studies have used convolutional neural networks (CNNs) to identify peripheral blood leukocytes, but there limitations in the small receptive field of model. Our model introduces a transformer based on CNN,...
ABSTRACT Leukemia is a hematological malignancy that significantly impacts the human immune system. Early detection helps to effectively manage and treat cancer. Although deep learning techniques hold promise for early of blood disorders, their effectiveness often limited by physical constraints available datasets deployed devices. For this investigation, we collect an excellent‐quality dataset 17,826 morphological bone marrow cell images from 85 patients with lymphoproliferative neoplasms....
HMSNs are coated with oxidized hyaluronic acid (OHA) by a pH-sensitive Schiff base bond and redox-sensitive disulfide bond.
Besides the traditional roles of HBA1 and HBB, recent findings suggest that hemoglobin genes may have in other contexts.In present study, we aim to investigate a possible tumor-suppressor role HBB acute myeloid leukemia.Quantitative real-time PCR (RT-qPCR) was performed detect expression levels leukemia patients AML cell lines. The transfected cells were analyzed for Cell Counting Kit-8 (CCK-8), apoptosis, cycle assay.HBA1 significantly decreased Furthermore, vitro approaches showed...
Abnormal coagulation parameters and potential benefits of anticoagulant therapy in general population with novel coronavirus pneumonia (COVID-19) have been reported. However, limited data are available on cancer patients. Coagulation indexes inflammation 57 patients SARS-CoV-2 infection different severity were retrospectively analyzed. We found that D-dimer levels increased 33 (57.9%, median: 790 ng/mL). Compared ordinary type patients, severe critical ill had decreased MPV values (P =...
As no unified treatment protocol or evidence yet exists for plasmapheresis without plasma, this study explored the outcomes of using 4% human albumin (ALB) solution as a replacement in patients undergoing plasma exchange multiple myeloma (MM) with acute kidney injury (AKI). This was prospectively registered (ChiCTR2000030640 and NCT05251896). Bortezomib-based chemotherapy plus therapeutic (TPP) ALB assessed three years MM aged >18 years, AKI according to Kidney Disease Improving Global...
Vibrio are ubiquitous in the marine environment, and some of them pathogenic to organisms humans. Due complexity sensitivity traditional phenotypic biochemical tests, there is currently no method that could distinguish on market. Therefore, this study developed new primers based gyrB gene identify Vibrio. We designed 7 pairs PCR (DP1-DP7) pre-selected using standard strains The results showed efficiency DP1 (VF1:5′-AARCARGGNCGTAACCGTAA-3′, VR1: 5′-HGGGTADCGRCGRCTCAT-3′) was better. After...
It was our aim to study the diagnostic significances of various dysplasia characteristics in myelodysplastic syndrome (MDS).We analyzed 160 cases primary MDS and a control group including 28 paroxysmal nocturnal hemoglobinuria (PNH), 104 idiopathic thrombocytopenic purpura (ITP), 53 non-severe aplastic anemia (NSAA), 40 megaloblastic 50 infectious autoimmune diseases. Peripheral blood smears bone marrow morphology were reviewed.There no significant difference occurrence rates variety...