A5076808323- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- stochastic dynamics and bifurcation
- Gene Regulatory Network Analysis
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- Mental Health Treatment and Access
- Immune cells in cancer
- Technology Adoption and User Behaviour
- Advanced Thermodynamics and Statistical Mechanics
- Electrochemical sensors and biosensors
- Epigenetics and DNA Methylation
- Behavioral Health and Interventions
- Plant biochemistry and biosynthesis
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Economic Policies and Impacts
- Photodynamic Therapy Research Studies
- Advanced Thermoelectric Materials and Devices
- Phytochemical compounds biological activities
- Ferroptosis and cancer prognosis
- Corporate Finance and Governance
- RNA and protein synthesis mechanisms
- Perfectionism, Procrastination, Anxiety Studies
Sun Yat-sen University
2005-2025
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Hengshui University
2024
Guangzhou Medical University
2024
Jinzhou Medical University
2024
Tianjin Medical University
2024
Tianjin University
2024
Research Institute of Petroleum Exploration and Development
2024
Sichuan University
2023
West China Medical Center of Sichuan University
2023
Abstract Patients with primary and bone metastatic breast cancer have significantly reduced survival life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy limited response rate immunotherapy for cancer, effective treatment remains a formidable challenge. In this work, engineered macrophages (Oxa(IV)@ZnPc@M) carrying nanomedicine containing oxaliplatin prodrug photosensitizer are designed as near-infrared (NIR) light-activated vectors, aiming achieve enhanced...
An efficient simulation algorithm for chemical kinetic systems with disparate rates is proposed. This new quite general, and it amounts to a simple seamless modification of the classical stochastic (SSA), also known as Gillespie [J. Comput. Phys. 22, 403 (1976); J. Chem. 81, 2340 (1977)] algorithm. The basic idea use an outer SSA simulate slow processes computed from inner which simulates fast reactions. Averaging theorems Markov can be used identify variables in system well effective...
Interfacial degradations dominate the performance decay of O3-layered cathode during low-voltage cycling; high voltage cycling induced bulk failures cause rapid due to transition metal cation migration.
Background Many university students are lacking adequate physical exercise and failing to develop activity (PA) behaviors in China. PA app use could improve this situation. Objective The aim of study was the unified theory acceptance technology (UTAUT) investigate intention apps among Guangzhou, China, how body mass index (BMI) moderates effects UTAUT explaining intention. Methods A cross-sectional conducted 1704 from different universities model used measure determinants apps. Results Of...
Brown planthopper (BPH, Nilaparvata lugens), a highly destructive insect pest, poses serious threat to rice (Oryza sativa) production worldwide. Jasmonates are key phytohormones that regulate plant defences against BPH; however, the molecular link between jasmonates and BPH responses in remains largely unknown. Here, we discovered Poaceae-specific metabolite, mixed-linkage β-1,3;1,4-d-glucan (MLG), which contributes jasmonate-mediated resistance. MLG levels significantly increased upon...
Background Human papillomavirus (HPV) is associated with a substantial percentage of cervical cancer, and significant anal, penile, vaginal, vulvar, oral cavity, oropharyngeal, laryngeal cancers. Understanding the burden trends HPV‐attributable cancers crucial to HPV prevention strategies. In current study, authors estimated latest in China. Methods Data from following sources were used. The number new cancer cases deaths China based on Cancer Registry Annual Report. population‐attributable...
Numerous particulate matter (PM) sensors with great development potential have emerged. However, whether the current can be used for reliable long-term field monitoring is unclear. This study describes research and application prospects of low-cost miniaturized in PM2.5 monitoring. We evaluated five Plantower PMSA003 deployed Beijing, China, over 7 months (October 2019 to June 2020). The tracked concentrations, which were compared measurements at national control station Ministry Ecology...
Chromatin modifications, such as histone acetylation, ubiquitination, and methylation, play fundamental roles in maintaining chromatin architecture regulating gene transcription. Although their crosstalk remodeling has been gradually uncovered, the functional relationship between ubiquitination methylation immunity inflammation remains unclear. Here, it is reported that USP38 a novel deubiquitinase works together with H3K4 modifier KDM5B to orchestrate inflammatory responses. specifically...
Abstract Fibroblast-like synoviocytes (FLSs), play a key role in perpetuating synovial inflammation and bone erosion rheumatoid arthritis (RA), however, the underlying mechanism(s) of RA FLSs activation aggression remain unclear. Identifying endogenous proteins that selectively target is urgently needed. Here, we systematically identified secreted modular calcium-binding protein 2 (SMOC2), was significantly increased tissues. SMOC2 knockdown specifically regulated cytoskeleton remodeling...
Hypoxia is a typical feature of solid tumors, which highly limits the application oxygen-dependent therapy. Also, dense and hyperbaric tumor tissues impede penetration nanoparticles into deep tumor. Thereby, we designed novel localized injectable hydrogel combining photothermal therapy (PTT) thermodynamic (TDT), based on generation free radicals even in absence oxygen for hypoxic In our study, gold nanorods (AuNRs) 2,2′-Azobis[2-(2-imidazalin-2-yl)propane] dihydrochlaride (AIPH) were...
Autophagy is a fundamental cellular process of protein degradation and recycling that regulates immune signaling pathways via multiple mechanisms. However, it remains unclear how autophagy epigenetically the response. Here, we identified TRIM14 as an epigenetic regulator reduces histone H3K9 trimethylation by inhibiting autophagic demethylase KDM4D. recruited deubiquitinases USP14 BRCC3 to cleave K63-linked ubiquitin chains KDM4D, which prevented KDM4D from undergoing optineurin...
Perioperative neurocognitive disorder, particularly postoperative cognitive impairment, is common and associated with multiple medical social adversities, although data from China are lacking.To examine the incidence, trajectory, risk factors for subjective short-term memory impairment after surgery in Chinese population.This cohort study used Surgery Anesthesia Cohort to assess surgical patients aged 40 65 years 2 centers between July 15, 2020, March 31, 2023, active follow-up within 1 year...
SUMMARY Rhododendron species have the potential to be rich in secondary metabolites with pharmaceutical or industrial value. However, there is a lack of comprehensive metabolome studies at genome level, particularly for unique and rare like bailiense , which exclusively grows karst environments Guizhou, southwest China. Recently, assembly data this was available. In study, nontargeted metabolomics employed investigate profile R. callus. The callus induced using 0.2 mg L −1 TDZ (Thidiazuron)...
Club drugs and alcohol abuse are prevalent among methadone maintenance treatment (MMT) patients. However, little is known about the association between these outcomes MMT The aim of this study was to examine prevalence club patients investigate associations – dropout poor adherence. In one-year cohort conducting in Guangzhou, China, data including background characteristics, use last six months, history treatment-related information collected. Cox regression analyses log-binomial were...
A considerable proportion of methadone maintenance treatment (MMT) clients have experienced mental health problems (e.g., depression and anxiety), poor status is associated with HIV-related risk behaviors drop-out. Resilience known to be a protective factor for but not studied among MMT in China. This study aimed explore the relationship between resilience (depression, anxiety stress) community-based clinics total 208 completed face-to-face interview conducted at 4 11 Guangzhou. The Chinese...
Little was known about the relationship between perceived neighborhood environment and depression among residents living in mega-communities. Furthermore, mediating effects of physical activity (PA) anxiety this have not been investigated. Thus, study aimed to comprehensively examine association mega-communities, test whether PA mediated association.