A5100331634- Reinforcement Learning in Robotics
- Neuroinflammation and Neurodegeneration Mechanisms
- Technology Adoption and User Behaviour
- Behavioral Health and Interventions
- Pancreatitis Pathology and Treatment
- Zebrafish Biomedical Research Applications
- Neonatal Respiratory Health Research
- Neurogenesis and neuroplasticity mechanisms
- Concrete and Cement Materials Research
- Concrete Properties and Behavior
- Biological and pharmacological studies of plants
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Respiratory Support and Mechanisms
- Impact of Technology on Adolescents
- Data Stream Mining Techniques
- Chronic Lymphocytic Leukemia Research
- Lipoproteins and Cardiovascular Health
- Advanced Bandit Algorithms Research
- Innovative concrete reinforcement materials
- Lipid metabolism and disorders
- Cardiac Valve Diseases and Treatments
- Sleep and related disorders
Third Affiliated Hospital of Zhengzhou University
2025
Southeast University
2024-2025
Chinese Academy of Agricultural Sciences
2022-2024
Sanya University
2023-2024
St. Michael's Hospital
2022-2024
University of Toronto
2023-2024
University of Electronic Science and Technology of China
2022-2024
Institute of Food Science and Technology
2023-2024
Renmin Hospital of Wuhan University
2024
Wuhan University
2024
Objective To investigate the relationship between Non-High-Density Lipoprotein Cholesterol to High-Density Ratio (NHHR) and infertility in US female adults aged 20 45. Methods Our research team utilized data from 2013–2018 National Health Nutrition Examination Survey (NHANES) conduct a cross-sectional study. Multivariable logistic regression was conducted examine association NHHR infertility, with trend tests providing additional insight into this relationship. Further, smoothed curve...
Background Many university students are lacking adequate physical exercise and failing to develop activity (PA) behaviors in China. PA app use could improve this situation. Objective The aim of study was the unified theory acceptance technology (UTAUT) investigate intention apps among Guangzhou, China, how body mass index (BMI) moderates effects UTAUT explaining intention. Methods A cross-sectional conducted 1704 from different universities model used measure determinants apps. Results Of...
Polygonum sibiricum polysaccharides (PSP) are one of the main active components Polygonatum sibiricum. The present study was performed to deeply explore antidepressant-like effects PSP on chronic unpredictable mild stress (CUMS)-induced depression and underlying mechanisms. markedly reversed depression-like behavior significantly increased levels 5-hydroxytryptamine norepinephrine, decreased pro-inflammatory cytokines in hippocampus corticosterone adrenocorticotropic-hormone serum...
<h3>Importance</h3> Immune checkpoint inhibitors can produce distinct toxic effects that require prompt recognition and timely management. <h3>Objective</h3> To develop a technology-enabled, dynamically adaptive protocol provide the accurate information needed to inform specific remedies for immune in patients treated with inhibitors. <h3>Design, Setting, Participants</h3> An open-label cohort study was conducted at single tertiary referral center from September 6, 2019, 3, 2020. The median...
Background and Aims Dietary factor plays an important role in the prevention of cardiovascular disease (CVD). The healthy eating index-2015 (HEI-2015), indicator overall dietary quality, has been introduced to reflect adherence 2015–2020 Guidelines for Americans (DGA). This study aims explore associations HEI-2015 with predicted 10-year CVD risk heart age among United States adults aged 30–74 years old using data from National Health Nutrition Examination Survey (NHANES) 2011–2014. Methods...
The flow cytometry-based evaluation of TRBC1 expression has been demonstrated as a rapid and specific method for detecting T-cell clones in sCD3-positive TCRαβ+ mature lymphoma. aim the study was to validate utility surface (s) cytoplastic (cy) assessment clonality sCD3-negative peripheral lymphomas (PTCLs), well exploring existence characteristics clonal populations with uncertain significance (T-CUS). Evaluation sTRBC1 cyTRBC1 were assessed on 61 samples from 37 patients PTCLs, including...
Despite similar infection rates, COVID-19 has resulted in more deaths men than women. To understand the underlying mechanisms behind this sex-biased difference disease severity, we infected K18-human angiotensin converting enzyme 2 (ACE2) mice of both sexes with SARS-CoV-2. Our study revealed a unique protein expression profile lung microenvironment female mice. As result, they were less vulnerable to severe infection, higher ACE2 and estrogen receptor α (ERα)/androgen (AR) ratio that led...
Surgical ablation is an option for patients with atrial fibrillation (AF) undergoing concomitant cardiac surgery. This study aims to evaluate the outcome of surgical during surgery and identify independent predictors a primary end-point consisting AF or flutter (AFL) recurrence, death, permanent pacemaker implantation necessity anti-arrhythmic drugs effects reintervention AF/AFL recurrence.A retrospective analysis was performed 1028 who underwent from October 2004 April 2015. Nine hundred...
Polysaccharides are one of the main active ingredients Polygonum sibiricum (PS), which is a food and medicine homolog used throughout Chinese history. The antidepressant-like effects PSP its underlying mechanisms remain elusive, especially regulation microglial polarization. current study determined chemical composition structural characteristics PSP. Then, chronic unpredictable mild stress (CUMS) procedure was carried out on zebrafish for 5 weeks, immersed 9 days (1 h/d). body weight...
Statins are highly prevalent in patients with coronary artery disease. exert their anti-inflammatory effects on the vascular wall and circulating levels of pro-inflammatory cytokines. However, increasing attention revealed exacerbation macrophage inflammation induced by statins, a clear mechanistic explanation whether detrimental statins inflammatory phenotypes outweigh beneficial is has not yet been established. Here, RNA-sequencing RT-qPCR analyses demonstrated that significantly...
Abstract Complicated thumb loss of the hand still remains a great challenge to and microsurgeons. In this article, we report our technique outcomes in 10 cases using one‐stage microsurgical procedures. each case, three tissue transplants combination with sequential vascular anastomoses was performed, i.e. second toe for thumb, extensor digitorum brevis thenar opponent muscle, anterolateral thigh flap first web space, adjacent soft defects. All survived eventually. After an average 6 years...
Coronary artery disease (CAD), a critical condition resulting from systemic inflammation, metabolic dysfunction, and gut microbiota dysbiosis, poses global public health challenge. ALW-II-41-27, specific inhibitor of the EphA2 receptor, has shown anti-inflammatory prosperities. However, impact ALW-II-41-27 on atherosclerosis not been elucidated. This study aimed to examine roles pharmacologically inhibiting underlying mechanism in ameliorating atherosclerosis. was administered apoE−/− mice...
The traditional processing of Dendrobium officinale (DO) is manufactured through five necessary steps: fresh strips, drying at 85 °C, curling, molding, and 35 °C (Fengdou), the antioxidant activity DO were increased after into Fengdou. To comprehensively analyses changing functional components, a plant-wide target metabolomics employed. In total, 739 differential ingredients identified in treatments, mainly highlighting differences variation with phenolic acids, flavonoids, lipids, amino...
Offline reinforcement learning enables agents to leverage large pre-collected datasets of environment transitions learn control policies, circumventing the need for potentially expensive or unsafe online data collection. Significant progress has been made recently in offline model-based learning, approaches which a learned dynamics model. This typically involves constructing probabilistic model, and using model uncertainty penalize rewards where there is insufficient data, solving...
As a dietary and medicinal plant, Dendrobium fimbriatum (DF) is widely utilized in China for improving stomach disease centuries. However, the underlying mechanisms against gastric mucosal injury have not been fully disclosed. Here, metabolomics proteomics were integrated to clarify in-depth molecular using cyclophosphamide-induced model mice. result, three metabolic pathways, such as creatine metabolism, arginine proline pyrimidine metabolism hit contributing DF protective benefits....
A key theme in the past decade has been that when large neural networks and datasets combine they can produce remarkable results. In deep reinforcement learning (RL), this paradigm is commonly made possible through experience replay, whereby a dataset of experiences used to train policy or value function. However, unlike supervised self-supervised learning, an RL agent collect its own data, which often limited. Thus, it challenging reap benefits even small overfit at start training. work, we...
Abstract Background Mechanical ventilation is applied to unload the respiratory muscles, but knowledge about transpulmonary driving pressure (Δ P L ) important minimize lung injury. We propose a method estimate Δ during neurally synchronized assisted ventilation, with simple intervention of lowering assist for one breath (“lower maneuver”, LAM). Methods In 24 rabbits breathing spontaneously imposed loads, titrations increasing were performed, two modes: adjusted ventilatory (NAVA) and...