A5032452524- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Sulfur Compounds in Biology
- Luminescence and Fluorescent Materials
- Luminescence Properties of Advanced Materials
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Industrial Technology and Control Systems
- Cancer Research and Treatments
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Analytical Chemistry and Sensors
- Medical Imaging and Pathology Studies
- Liver Disease Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Cardiovascular Function and Risk Factors
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
Dalian University of Technology
2012-2024
Athinoula A. Martinos Center for Biomedical Imaging
2023-2024
Harvard University
2023-2024
Massachusetts General Hospital
2023-2024
Dalian University
2015-2023
Institute for Learning Innovation
2023
Boston University
2023
China Academy of Engineering Physics
2005-2009
State Key Laboratory of Urban and Regional Ecology
2007
Institute of Forensic Science
2004
A dual-emissive nanoarchitecture of lanthanide-complex-modified silica particles was developed for real-time ratiometric time-gated luminescence imaging HClO<italic>in vivo</italic>.
As a critical gasotransmitter, carbon monoxide (CO) has been demonstrated to be related with mitochondrial respiration, but the monitoring of CO in mitochondria remains great challenge. In this work, unique ratiometric time-gated luminescence (TGL) probe, Mito-NBTTA-Tb3+/Eu3+, that can specifically respond developed. The probe was designed by incorporating mitochondria-targeting moiety, triphenylphosphonium, into CO-activatable terpyridine polyacid derivative,...
Liver injury can result from various risk factors including diabetes, virus, alcohol, drugs, and other toxins, which is mainly responsible for global mortality morbidity. Selenocysteine (Sec), as the main undertaker of selenium function in life system, features prominently a series hepatic injuries has close association with pathological progression liver injuries. Here, we report mitochondria-targetable lanthanide complex-based probe, Mito-NPTTA-Tb3+/Eu3+, that be used accurately...
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy. A major challenge in patient management the lack of a reliable imaging tool to monitor tumor response treatment. Tumor-associated fibrosis characterized by high type I collagen hallmark PDAC, further increases neoadjuvant chemoradiotherapy (CRT). We hypothesized that molecular positron emission tomography (PET) using collagen-specific probe,
Bioresponsive luminescence probes based on lanthanide complexes have shown great utility in a variety of time-gated bioassays. However, functional that can target individual organelles for probing biospecies therein rarely been investigated. In this work, unique Eu3+ complex, Mito-NPSTTA-Eu3+, was designed and synthesized as probe the sensing HOCl inside mitochondria living cells. The showed fast, highly sensitive selective response to with wide available pH range (pH 3-10), specific...
Sensitive optical imaging of active biomolecules in the living organism requires both a molecular probe specifically responsive to target and high-contrast approach remove background interference from autofluorescence light scatterings. Here, for ascorbic acid (vitamin C) has been developed by conjugating two nitroxide radicals with long-lived luminescent europium complex. The radical withholds on its "off" state (barely luminescent), until presence vitamin C will switch forming...
During fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on matrix proteins to form aldehyde allysine. Here we report three Mn(II)-based, small-molecule magnetic resonance probes that contain α-effect nucleophiles target allysine in vivo and tissue fibrogenesis. We used a rational design approach develop turn-on with 4-fold increase relaxivity upon targeting. The effects condensation rate hydrolysis kinetics performance detect...
A visible-light-excitable Eu3+ complex-based luminescent probe, [Eu(pdap)3(DPBT)], has been proposed for time-gated luminescence imaging of singlet oxygen in the mitochondria living cells, as well tumor tissues and laboratory animals. Extension excitation window to visible-light region makes probe more favorable practical usage.
Abstract Two novel organic fluorophores, containing bis‐naphthylamide and quinoline motifs, have been designed synthesized. One of the fluorophores contains an isobutylene unit exhibits a significant aggregation‐induced emission (AIE) remarkable highly selective ratiometric fluorescence response towards Zn 2+ in solution as well human liver cancer cells. The AIE behavior this fluorophore was fully verified by UV/Vis spectroscopy, quantum yield calculations, single‐crystal X‐ray diffraction,...
A novel nanoprobe based on Eu(<sc>iii</sc>) complex–MnO<sub>2</sub>nanosheet nanocomposites has been prepared for dual-modal TGL/MR imaging of GSH<italic>in vitro</italic>and<italic>in vivo</italic>.
A mitochondria targetable ratiometric luminescence probe based on a mixture of Eu3+ and Tb3+ complexes, Mito-NSTTA-Eu3+/Tb3+, has been developed for the specific recognition time-gated detection biothiols in aqueous living samples. This was synthesized by conjugating mitochondria-anchoring motif, triphenylphosphonium, with biothiol-responsive terpyridine derivative, [4'-(2,4-dinitrobenzenesulfonyloxy)-2,2':6',2''-terpyridine-6,6''-diyl] bis(methylenenitrilo) tetrakis(acetic acid),...
A multifunctional nanoprobe for tumor-targeted time-gated luminescence and magnetic resonance imaging <italic>in vitro</italic> vivo</italic>.
Abstract Neoadjuvant therapy is routinely used in pancreatic ductal adenocarcinoma (PDAC), but not all tumors respond to this treatment. Current clinical imaging techniques are able precisely evaluate and predict the response neoadjuvant therapies over several weeks. A strong fibrotic reaction a hallmark of positive response, during fibrogenesis, allysine residues formed on collagen proteins by action lysyl oxidases. Here, we report application an allysine-targeted molecular MRI probe, MnL3,...
A homogeneous time-resolved fluoroimmunoassay method for rapid and sensitive detection of microcystin-LR (MC-LR) in water samples was developed based on the interaction between water-soluble WS2 nanosheets conjugate MC-LR with a luminescent Eu3+ complex BHHBCB-Eu3+ (BHHBCB: 1,2-bis[4'-(1″,1″,1″,2″,2″,3″,3″-heptafluoro-4″,6″-hexanedion-6″-yl)- benzyl]-4-chlorosulfobenzene). The large lateral dimensions high surface areas two-dimensional layered enable easy adsorption MC-LR-BHHBCB-Eu3+...