A5103043210- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Sulfur Compounds in Biology
- Atomic and Subatomic Physics Research
- Medical Imaging and Pathology Studies
- Adenosine and Purinergic Signaling
- T-cell and B-cell Immunology
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
Charles River Associates
2024
Massachusetts General Hospital
2021-2024
Harvard University
2023-2024
Center for Cancer Research
2021
During fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on matrix proteins to form aldehyde allysine. Here we report three Mn(II)-based, small-molecule magnetic resonance probes that contain α-effect nucleophiles target allysine in vivo and tissue fibrogenesis. We used a rational design approach develop turn-on with 4-fold increase relaxivity upon targeting. The effects condensation rate hydrolysis kinetics performance detect...
Pulmonary fibrosis is characterized by the accumulation of myofibroblasts in lung and progressive tissue scarring. Fibroblasts exist across a spectrum states, from quiescence health to activated setting injury. Highly have critical role establishment as predominant source type 1 collagen profibrotic mediators. Myofibroblasts are also highly contractile cells can alter biomechanical properties through contraction. Inhibiting signaling pathways involved myofibroblast activation could therefore...
Aging-associated left ventricular dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right failure. At the time of diagnosis, cardiac function has declined, fibrosis often developed. Here, we sought to develop a molecular positron emission tomography (PET)-magnetic resonance imaging (MRI) protocol detect both fibrotic disease activity in model.
During fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on matrix proteins to form aldehyde allysine. Here we report three Mn(II)-based, small molecule magnetic resonance (MR) probes that contain α-effect nucleophiles target allysine in vivo and tissue fibrogenesis. We used a rational design approach develop turn-on with 4-fold increase relaxivity upon targeting. The effects condensation rate hydrolysis kinetics performance detect...
Group 2 pulmonary hypertension is a complication of chronic left ventricular dysfunction. During the early stages disease activity there an accumulation extracellular matrix molecules and increase in allysine content. Molecular MR imaging with allysine-targeted fibrogenesis probe shows increased lung-to-muscle ΔCNR within lungs transverse aortic constriction (TAC)-induced dysfunction animal models compared to control animals, which corresponded lung right ventricle weight,...
Abstract Background Aging-associated left ventricular (LV) dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right failure. At the time of diagnosis, cardiac function has declined, fibrosis often developed. Here, we sought to develop a molecular positron emission tomography (PET)-magnetic resonance imaging (MRI) protocol detect both fibrotic disease activity in an LV model. Methods was induced by transverse aortic constriction (TAC)...