About
Contact & Profiles
A5015780791
Research Areas
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Immune cells in cancer
Sun Yat-sen University
2022
Autophagy is a fundamental cellular process of protein degradation and recycling that regulates immune signaling pathways via multiple mechanisms. However, it remains unclear how autophagy epigenetically the response. Here, we identified TRIM14 as an epigenetic regulator reduces histone H3K9 trimethylation by inhibiting autophagic demethylase KDM4D. recruited deubiquitinases USP14 BRCC3 to cleave K63-linked ubiquitin chains KDM4D, which prevented KDM4D from undergoing optineurin...
10.1073/pnas.2113454119
article
EN
cc-by-nc-nd
Proceedings of the National Academy of Sciences
2022-02-10
Coming Soon ...