A5081341048- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 detection and testing
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Vaccine Coverage and Hesitancy
- Climate Change and Health Impacts
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Air Quality and Health Impacts
- Fatty Acid Research and Health
- Pain Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Intensive Care Unit Cognitive Disorders
- Advanced Glycation End Products research
- Anesthesia and Neurotoxicity Research
- Monoclonal and Polyclonal Antibodies Research
- Barrier Structure and Function Studies
- Ferroptosis and cancer prognosis
- Airway Management and Intubation Techniques
- Immunotherapy and Immune Responses
University of Shanghai for Science and Technology
2024-2025
Union Hospital
2014-2024
Huazhong University of Science and Technology
2013-2024
Union Hospital
2012-2024
University of Hong Kong
2020-2024
University of Electronic Science and Technology of China
2024
Hong Kong Science and Technology Parks Corporation
2022-2023
Duke-NUS Medical School
2023
Imperial College London
2023
Wuhan Union Hospital
2021-2022
When a new infectious disease emerges, appropriate case definitions are important for clinical diagnosis and public health surveillance. Tracking numbers over time is to establish the speed of spread effectiveness interventions. We aimed assess whether changes in affected inferences on transmission dynamics coronavirus 2019 (COVID-19) China.We examined definition COVID-19 mainland China during first epidemic wave. used exponential growth models estimate how number cases reported each day....
Our analysis of data collected from multiple epidemics in Hong Kong indicated a shorter serial interval and generation time infections with the SARS-CoV-2 Omicron variant. The age-specific case-fatality risk for BA.2.2 case-patients without complete primary vaccination was comparable to that persons infected ancestral strains earlier waves.
Abstract The brain and the immune system interact in complex ways after ischemic stroke, long-term effects of response associated with stroke remain controversial. As a linkage between innate adaptive immunity, interleukin-17 A (IL-17 A) secreted from gamma delta (γδ) T cells has detrimental roles pathogenesis acute stroke. However, to date, actions IL-17 have not been investigated. Here, we found that showed two distinct peaks expression hemisphere: first occurring within 3 days second on...
Recombinant adeno-associated virus (rAAV) vectors are a leading gene delivery platform, but vector manufacturing remains challenge. New methods needed to increase rAAV yields and reduce costs. Past efforts improve production have focused on optimizing single variable at time, this approach does not account for the interactions of multiple factors that contribute generation. Here, we utilized design-of-experiment (DOE) methodology optimize in HEK293T suspension cell system. We simultaneously...
The coronavirus disease 2019, named COVID-19 officially by the World Health Organization (Geneva, Switzerland) on February 12, 2020, has spread at unprecedented speed. After first outbreak in Wuhan, China, Chinese anesthesiologists encountered increasing numbers of infected patients since December 2019. Because main route transmission is via respiratory droplets and close contact, anesthesia providers are a high risk when responding to devastating mass emergency. So far, actions have been...
Hong Kong contained COVID-19 for two years but experienced a large epidemic of Omicron BA.2 in early 2022 and endemic transmission subvariants thereafter. We reflected on pandemic preparedness responses by assessing associated disease burden the context implementation various public health social measures (PHSMs).We examined use impact controls analysing data more than 1.7 million confirmed cases characterizing temporal changes non-pharmaceutical pharmaceutical interventions implemented from...
Hyperforin, a lipophilic constituent of medicinal herb St John's wort, has been identified as the main active ingredient wort extract for antidepressant action by experimental and clinical studies. Hyperforin is currently known to activate transient receptor potential canonical (subtype) 6 (TRPC6) channel, increase phosphorylated CREB (p-CREB), N-methyl-D-aspartate receptor-antagonistic effect that convert neuroprotective effects in vitro. However, protective hyperforin on ischemic stroke...
Melanoma is an aggressive form of skin cancer, and a worldwide problem with increasing incidence. Little known about the burden melanoma in Chinese population. We evaluated temporal trends geographic variation melanoma-associated burden, to narrow important knowledge gap concerning consequences this disorder across time, provinces China. After general analytic strategy used 2017 Global Burden Disease study, we analyzed incidence, mortality, prevalence disability-adjusted life-years (DALYs)...
Abstract P38MAPK mediates cytokine induced inflammation in nucleus pulposus (NP) cells and involves multiple cellular processes which are related to intervertebral disc degeneration (IDD). The aim of this study was investigate the expression, activation function p38 MAPK isoforms (α,β, γ δ) degenerative NP effect on macrophage polarization. P38 α, β δ preferential expressed, whereas p38γ isoform is absent human tissue. LV-sh-p38α, sh-p38β transfection significantly decreased ADAMTS-4,-5,...
Abstract Background The relative contributions of asymptomatic, presymptomatic, and symptomatic transmission severe acute respiratory syndrome coronavirus 2 have not been clearly measured, although control measures may differ in response to the risk spread posed by different types cases. Methods We collected detailed information on events symptom status based laboratory-confirmed patient data contact tracing from 4 provinces 1 municipality China. estimated variation over time severity...
The biological functions of lipids largely depend on their chemical structures. position and configuration C=C bonds are two the essential attributes that determine structures unsaturated lipids. However, simultaneous identification both remains challenging. Here, we develop a bifunctional visible-light-activated photocycloaddition-photoisomerization reaction system, which enables dual-resolving positional geometric isomerism in when combines with liquid chromatography-mass spectrometry....
Our study is the first to illustrate age and geographic distribution differences in epidemiology of prostate cancer from 1990 2019 China. Prostate (PC) a malignant tumor derived epithelial cells one most commonly diagnosed cancers men. In recent years, global incidence annual deaths number PC showed continuous increase, which has caused huge disease burden on human health. terms average, mortality China are relatively low. However, age-standardized rate was 17.3/100,000 China, with 95.2%...
ABSTRACT Hong Kong reported 12,631 confirmed COVID-19 cases and 213 deaths in the first two years of pandemic but experienced a major wave predominantly Omicron BA.2.2 early 2022 with over 1.1 million SARS-CoV-2 infections more than 7900 deaths. Our data indicated shorter incubation period, serial interval, generation time other variants. without complete primary vaccination series appeared to face similar fatality risk those infected earlier waves ancestral strain.
Abstract Background Hong Kong maintained extremely low circulation of SARS-CoV-2 until a major community epidemic Omicron BA.2 starting in January 2022. Both mRNA BNT162b2 (BioNTech/Fosun Pharma) and inactivated CoronaVac (Sinovac) vaccines are widely available, however coverage has remained older adults. Vaccine effectiveness this predominantly infection-naïve population is unknown. Methods We used individual-level case data on mild/moderate, severe/fatal fatal hospitalized COVID-19 from...
Abstract Many locations around the world have used real-time estimates of time-varying effective reproductive number ( $${R}_{t}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mrow> <mml:mi>R</mml:mi> </mml:mrow> <mml:mi>t</mml:mi> </mml:msub> </mml:math> ) COVID-19 to provide evidence transmission intensity inform control strategies. Estimates are typically based on statistical models applied case counts and suffer lags more than a week because latent period...
Understanding severity of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants is crucial to inform public health measures. Here we used disease 2019 (COVID-19) patient data from Hong Kong characterize the profile COVID-19.Time-varying age-specific effective measured by case hospitalization risk fatality was estimated all individual COVID-19 collected in 23 January 2020 through 26 October 2022 over 6 epidemic waves. The intrinsic Omicron BA.2 compared...
Accurate lipid quantification is essential to revealing their roles in physiological and pathological processes. However, difficulties the structural resolution of isomers hinder further accurate quantification. To address this challenge, we developed a novel stable-isotope N-Me aziridination strategy that enables simultaneous qualification unsaturated isomers. The one-step introduction 1-methylaziridine structure not only serves as an activating group for C═C bond facilitate positional...
Post-stroke cognitive impairment (PSCI) is a major source of morbidity and mortality after stroke, but the pathological mechanisms remain unclear. Previous studies have demonstrated that CX3CR1 receptor plays crucial role in maintaining an early protective microenvironment whether it persistently influences dysfunction chronic phase requires further investigation.