A5086797955- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Global Cancer Incidence and Screening
- SARS-CoV-2 and COVID-19 Research
- Colorectal Cancer Screening and Detection
- Global Health Care Issues
- Healthcare Policy and Management
- Health Promotion and Cardiovascular Prevention
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Influenza Virus Research Studies
- Health disparities and outcomes
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Computational Drug Discovery Methods
- Pneumonia and Respiratory Infections
- Healthcare Systems and Reforms
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
University of Hong Kong
2015-2024
Chinese University of Hong Kong
2003-2024
York University
2013
Food and Health Bureau
2006
Prince of Wales Hospital
2004-2005
HKU-Pasteur Research Pole
2005
Pamela Youde Nethersole Eastern Hospital
2004
United Christian Hospital
2004
Hospital Authority
2004
As yet, no one has written a comprehensive epidemiologic account of severe acute respiratory syndrome (SARS) outbreak from an affected country.
Hong Kong contained COVID-19 for two years but experienced a large epidemic of Omicron BA.2 in early 2022 and endemic transmission subvariants thereafter. We reflected on pandemic preparedness responses by assessing associated disease burden the context implementation various public health social measures (PHSMs).We examined use impact controls analysing data more than 1.7 million confirmed cases characterizing temporal changes non-pharmaceutical pharmaceutical interventions implemented from...
Abstract The global rollout of COVID-19 vaccines faces a significant barrier in the form vaccine hesitancy. This study adopts dynamic and network perspective to explore determinants uptake Hong Kong, focusing on multi-level their interconnections. Following framework proposed by Strategic Advisory Group Experts (SAGE), used repeated cross-sectional surveys map these at multiple levels investigates interconnections simultaneously sample 15,179 over two years. results highlight nature...
Background A variety of Serfling-type statistical algorithms requiring long series historical data, exclusively from temperate climate zones, have been proposed for automated monitoring influenza sentinel surveillance data. We evaluated three alternative approaches where alert thresholds are based on recent data in both and subtropical regions. Methods compared time series, regression, cumulative sum (CUSUM) models empirical Hong Kong the US using a composite index (range = 0–1) consisting...
Abstract BACKGROUND. Although the cost effectiveness of screening mammography in most western developed populations has been accepted, it may not apply to Chinese women, who have a much lower breast cancer incidence. The authors estimated biennial Hong Kong women inform evidence‐based policies. METHODS. For current study, state‐transition Markov model was simulate screening, diagnosis, and treatment hypothetical cohort women. benefit modeled by assuming stage shift, which cancers screened...
Projections of future trends in cancer incidence and mortality are important for public health planning. By using 1976–2010 data Hong Kong, we fitted Poisson age-period-cohort models made projections breast to 2025. Age-standardised (/mortality) is projected increase (/decline) from 56.7 (/9.3) 2011–2015 62.5 (/8.6) per 100 000 women 2021–2025. The pattern may relate Kong's socio-economic developmental history, while falling are, most likely, due improvements survival treatment advancement...
Studies on healthcare-seeking behaviour usually adopted a patient care perspective, or restricted to specific disease conditions. However, pre-diagnosis symptoms may be more relevant from perspective. We described behaviours by related respiratory and gastrointestinal-related infections.We conducted longitudinal population-based telephone survey in Hong Kong. collected data of infections also associated demographic factors. performed descriptive analyses estimated the proportion participants...
Accurate and precise estimates of the incubation distribution novel, emerging infectious diseases are vital to inform public health policy parameterize mathematical models.We discuss compare different methods estimating allowing for interval censoring exposures, using data from severe acute respiratory syndrome (SARS) epidemic in 2003 as an example.Combining on unselected samples 149 168 patients with defined exposure intervals Toronto Hong Kong, respectively, we estimated mean variance...
We studied 2780 adults in Hong Kong who received CoronaVac inactivated virus vaccine (Sinovac) and BNT162b2 mRNA ("Comirnaty", BioNTech/Fosun Pharma). compared rates of antibody waning over time using an enzyme-linked immunosorbent assay for spike receptor binding domain a surrogate neutralization test. found stronger more durable responses to two doses the vaccine, slightly initial each younger women. The weaker less following support earlier provision third persons previously this vaccine.
Abstract There is limited evidence on vaccine effectiveness against asymptomatic or mild Omicron infections. We estimated that recent third doses of messenger RNA inactivated vaccines reduced the risk self-reported infection by 52% (95% confidence interval, 17%–73%) among randomly sampled adults during BA.2–dominated surge in Hong Kong.
ABSTRACT Background Hong Kong contained COVID-19 for two years, but experienced a large epidemic of Omicron BA.2 in early 2022 and endemic transmission subvariants thereafter. Methods We examined the use impact pandemic controls by analysing data on more than 1.7 million confirmed cases characterizing non-pharmaceutical pharmaceutical interventions implemented from January 2020 through to 30 December 2022. estimated daily effective reproductive number (R t ) track changes transmissibility...
Introduction: In orthopedic oncology, computer navigation and 3D-printed guides facilitate precise osteotomies only after surgical exposure. Before surgeries start, it is challenging to mentally process superimpose the virtual medical images onto patients' anatomy for preoperative planning. Mixed Reality (MR) an immersive technology merging real worlds, users can interact with digital objects in time. Through Head-Mounted Displays, surgeons directly visualize holographic models that overlaid...
Abstract Breast cancer incidence should be assessed separately in different populations, as it differs substantially between Chinese and Caucasian women, more generally developing versus developed populations. Estimation of future trends is important for public health planning. On the basis recent breast trends, we projected disease rates rapidly transitioning population Hong Kong. We used local data on mid‐year figures years 1974–2003. fitted Poisson age‐period‐cohort models with...
Nonattendance is a major health services research and management issue that has received little attention or systematic study in Asia. We examined the independent associations between waiting time, doctor shopping, nonattendance specialist outpatient clinics of 4 large public hospitals Hong Kong.Case-control study.A total 6495 attenders nonattenders enrolled from July 2000 through October 2001. PAIN OUTCOME MEASURES: Odds ratios (ORs) associated 95% confidence intervals (CI) for...
Given the slow adoption of medical informatics in Hong Kong and Asia, we sought to understand contributory barriers potential incentives associated with information technology implementation.A representative sample 949 doctors (response rate = 77.0%) was asked through a postal survey rank list nine clinical computerization according self-perceived importance. They ranked seven or catalysts that may influence computerization. We generated mean scores used multidimensional preference analysis...
Background: Accurate, objective models of triage for patients with suspected severe acute respiratory syndrome (SARS) could assess risks and improve decisions about isolation inpatient treatment. Objective: To develop validate a clinical prediction rule identifying SARS in an emergency department setting. Design: Retrospective analysis using 2-step coefficient-based multivariable logistic regression scoring method internal validation by bootstrapping. Setting: 2 hospitals Hong Kong....
Despite its wealth, excellent vital indices and robust health care infrastructure, Hong Kong has a relatively high incidence of tuberculosis (TB) (85.4 per 100 000). residents have also experienced very rapid recent epidemiological transition; the population largely originated from migration by southern Chinese in mid 20th century. Given potentially long latency period TB infection, an investigation was undertaken to determine extent which rates reflect history impact public interventions.An...
Abstract We constructed a coronavirus disease community vulnerability index using micro district-level socioeconomic and demographic data analyzed its correlations with case counts across the 3 pandemic waves in Hong Kong, China. found that districts greater reported more cases third wave when widespread outbreaks occurred.