A5006065098- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Immune Response and Inflammation
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Cytomegalovirus and herpesvirus research
- Infection Control and Ventilation
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Zoonotic diseases and public health
- Virus-based gene therapy research
- Vaccine Coverage and Hesitancy
- Respiratory Support and Mechanisms
- Parvovirus B19 Infection Studies
- Climate Change and Health Impacts
- Mosquito-borne diseases and control
University of Hong Kong
2016-2025
Hong Kong Science and Technology Parks Corporation
2021-2024
HKU-Pasteur Research Pole
2015-2024
University of Ontario Institute of Technology
2024
Chinese University of Hong Kong
2008-2023
University of Hong Kong - Shenzhen Hospital
2023
Université Grenoble Alpes
2022
Centre Hospitalier Universitaire de Grenoble
2022
National Centre for Infectious Diseases
2022
Tung Wah Eastern Hospital
2021-2022
Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that more widespread than initially thought, and international spread through travellers does already occur. Aim We aimed to develop deploy robust diagnostic methodology use in laboratory settings without having material available. Methods Here we present validated workflow 2019-nCoV, its...
An outbreak of severe acute respiratory syndrome (SARS) has been reported in Hong Kong. We investigated the viral cause and clinical presentation among 50 patients.We analysed case notes microbiological findings for patients with SARS, representing more than five separate epidemiologically linked transmission clusters. defined risk factors associated disease causal agents by chest radiography laboratory testing nasopharyngeal aspirates sera samples. compared those submitted investigation...
A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market Guangdong, China. Evidence virus infection was also detected other animals (including raccoon dog, Nyctereutes procyonoides ) and humans working at same market. All animal isolates retain 29-nucleotide sequence that not most human isolates. The detection small, live wild mammals retail indicates route...
We investigated the temporal progression of clinical, radiological, and virological changes in a community outbreak severe acute respiratory syndrome (SARS).We followed up 75 patients for 3 weeks managed with standard treatment protocol ribavirin corticosteroids, assessed pattern clinical disease, viral load, risk factors poor outcome, usefulness diagnostic methods.Fever pneumonia initially improved but 64 (85%) developed recurrent fever after mean 8.9 (SD 3.1) days, 55 (73%) had watery...
A phylogenetic analysis of swine-origin H1N1 influenza virus provides evidence that the is a reassortment possessing genes from avian, swine and human origin viruses. The pandemic appears to have evolved in way typical flu sequences prior entering humans, derived several viruses circulating swine. Initial transmission humans occurred months before recognition outbreak. An estimate gaps genetic surveillance points period years between lineages transfer multiple ancestry inconsistent with an...
Despite extensive laboratory investigations in patients with respiratory tract infections, no microbiological cause can be identified a significant proportion of patients. In the past 3 years, several novel viruses, including human metapneumovirus, severe acute syndrome (SARS) coronavirus (SARS-CoV), and NL63, were discovered. Here we report discovery another coronavirus, HKU1 (CoV-HKU1), from 71-year-old man pneumonia who had just returned Shenzhen, China. Quantitative reverse...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel with high nucleotide identity to SARS-CoV and SARS-related coronaviruses that have been detected in horseshoe bats, has spread across the world had global effect on healthcare systems economies1,2. A suitable small animal model is needed support development of vaccines therapies. Here we report pathogenesis transmissibility SARS-CoV-2 golden (Syrian) hamsters (Mesocricetus auratus). Immunohistochemistry assay demonstrated...
A novel coronavirus of zoonotic origin (2019-nCoV) has recently been identified in patients with acute respiratory disease. This virus is genetically similar to SARS and bat SARS-like coronaviruses. The outbreak was initially detected Wuhan, a major city China, but subsequently other provinces China. Travel-associated cases have also reported few countries. Outbreaks health care workers indicate human-to-human transmission. Molecular tests for rapid detection this are urgently needed early...
Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong Atlanta, Georgia, United States. In the peripheral blood mononuclear cells (PBMCs) of patients, we observed reduced expression leukocyte antigen class DR (HLA-DR) proinflammatory cytokines by myeloid as well impaired...
The main route of transmission SARS CoV infection is presumed to be respiratory droplets. However the virus also detectable in other body fluids and excreta. stability at different temperatures relative humidity on smooth surfaces were studied. dried retained its viability for over 5 days 22–25°C 40–50%, that is, typical air-conditioned environments. However, was rapidly lost (>3 log 10 ) higher (e.g., 38°C, >95%). better coronavirus low temperature environment may facilitate community...