Victor M. Corman
A5073782617- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Biosensors and Analytical Detection
- Hepatitis Viruses Studies and Epidemiology
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Rabies epidemiology and control
- Bacillus and Francisella bacterial research
- Hepatitis C virus research
- Acute Kidney Injury Research
- Poxvirus research and outbreaks
- Animal Diversity and Health Studies
- Animal Disease Management and Epidemiology
- Mosquito-borne diseases and control
- Zoonotic diseases and public health
- COVID-19 diagnosis using AI
Freie Universität Berlin
2018-2025
Humboldt-Universität zu Berlin
2018-2025
Charité - Universitätsmedizin Berlin
2017-2025
German Center for Infection Research
2016-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2025
Institute of Virology of the Slovak Academy of Sciences
2014-2025
Vivantes Klinikum
2021-2024
Queen Mary University of London
2024
University of Edinburgh
2024
Washington State University
2024
Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that more widespread than initially thought, and international spread through travellers does already occur. Aim We aimed to develop deploy robust diagnostic methodology use in laboratory settings without having material available. Methods Here we present validated workflow 2019-nCoV, its...
Abstract A new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged to cause a human pandemic. Although molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. Validated needed for contact tracing, identifying the viral reservoir, and epidemiologic studies. We developed detection of SARS-CoV-2 neutralizing, spike protein–specific, nucleocapsid-specific antibodies. Using serum samples from patients...
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic disease. Moreover, thromboembolic events throughout the body, including in CNS, have been described. Given neurological symptoms observed large majority of individuals with SARS-CoV-2 penetrance CNS is likely. By various means, we demonstrate presence RNA and protein anatomically distinct regions nasopharynx brain. Furthermore, describe morphological changes associated infection such...
The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample 119 bat rodent species (9,278 individuals). Major discoveries include evidence origin Hendra- Nipah Africa, identification conspecific with mumps virus, detection close relatives mouse pneumonia-...
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Two elementary parameters for quantifying viral infection and shedding are load whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Germany, including 6110 from test centers attended by presymptomatic, asymptomatic, mildly symptomatic (PAMS) subjects, 9519 who were hospitalized, 1533 B.1.1.7 lineage infections. The the youngest subjects was lower than that older 0.5 (or fewer) log
In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a disease presenting with fever, cough, and often pneumonia. WHO has set strategic objective to interrupt spread of SARS-CoV-2 worldwide. An outbreak Bavaria, Germany, starting at end January, 2020, provided opportunity study transmission events, incubation period, secondary attack rates.
Coronavirus disease 2019 (COVID-19) is an acute respiratory tract infection that emerged in late 1,2 . Initial outbreaks China involved 13.8% cases with severe-, and 6.1% critical courses 3 This severe presentation corresponds to the usage of a virus receptor expressed predominantly lung 2,4 By causing early onset symptoms, this same tropism thought have determined pathogenicity but also aided control syndrome (SARS) 2003 5 However, there are reports COVID-19 mild upper suggesting potential...
Bats may host emerging viruses, including coronaviruses (CoV). We conducted an evaluation of CoV in rhinolophid and vespertilionid bat species common Europe. Rhinolophids carried severe acute respiratory syndrome (SARS)-related at high frequencies concentrations (26% animals are positive; up to 2.4×10(8) copies per gram feces), as well two Alphacoronavirus clades, one novel related the HKU2 clade. All three clades present Miniopterus bats China (HKU7, HKU8, 1A related) were also European...
Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-CoV) depend on knowledge of rate human-to-human transmission, including subclinical infections. A lack serologic tools has hindered targeted studies transmission.We studied 26 index patients with MERS-CoV infection and their 280 household contacts. The median time from onset symptoms in latest blood sampling contact was 17.5 days (range, 5 216; mean, 34.4). Probable cases secondary transmission were identified basis...
ABSTRACT The emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes lethal infections mainly on the Arabian Peninsula. evolutionary origins of MERS-CoV are unknown. We determined full genome sequence a CoV directly from fecal material obtained South African Neoromicia capensis bat (NeoCoV). NeoCoV shared essential details architecture with MERS-CoV. Eighty-five percent was identical to at nucleotide level. Based taxonomic criteria, and belonged one viral species. presence...
The Middle East respiratory syndrome (MERS) coronavirus causes isolated cases and outbreaks of severe disease. Essential features the natural history disease are poorly understood. We studied 37 adult patients infected with MERS for viral load in lower upper tracts (LRT URT, respectively), blood, stool, urine. Antibodies serum neutralizing activities were determined over course One hundred ninety-nine LRT samples collected during 3 weeks following diagnosis yielded virus RNA 93% tests....
Human intestinal tract as an alternative route to acquire MERS-CoV infection.
Abstract We screened fecal specimens of 4,758 bats from Ghana and 272 4 European countries for betacoronaviruses. Viruses related to the novel human betacoronavirus EMC/2012 were detected in 46 (24.9%) 185 Nycteris 40 (14.7%) Pipistrellus bats. Their genetic relatedness indicated originated
Abstract Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has been associated with more than two million deaths worldwide. Patients of higher age preexisting chronic health conditions are at an increased risk fatal disease outcome. However, detailed information on causes death contribution pre-existing to yet is missing, which can be reliably established autopsy only. We performed full body autopsies 26 patients that had died after infection Charité...
We present a rigorously validated and highly sensitive confirmatory real-time RT-PCR assay (1A assay) that can be used in combination with the previously reported upE assay. Two additional assays for sequencing are described, targeting RdRp gene (RdRpSeq N (NSeq assay), where an insertion/deletion polymorphism might exist among different hCoV-EMC strains. Finally, simplified biologically safe protocol detection of antibody response by immunofluorescence microscopy was developed using...