A5046816531- Acute Myeloid Leukemia Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Respiratory Support and Mechanisms
- Pancreatitis Pathology and Treatment
- Neutropenia and Cancer Infections
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatological and COVID-19 studies
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ovarian cancer diagnosis and treatment
- Immune responses and vaccinations
- Acute Lymphoblastic Leukemia research
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sepsis Diagnosis and Treatment
Humboldt-Universität zu Berlin
2020-2025
Charité - Universitätsmedizin Berlin
2017-2025
Freie Universität Berlin
2020-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2024-2025
Abstract Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has been associated with more than two million deaths worldwide. Patients of higher age preexisting chronic health conditions are at an increased risk fatal disease outcome. However, detailed information on causes death contribution pre-existing to yet is missing, which can be reliably established autopsy only. We performed full body autopsies 26 patients that had died after infection Charité...
Abstract Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In study, we combine advanced imaging spatial transcriptomics to shed light on local immune response in severe COVID-19. We show that activated adventitial niches crucial microenvironments contributing orchestration of prolonged immunopathology. Up-regulation chemokines CCL21 CCL18 associates endothelial-to-mesenchymal...
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show in murine sepsis models, splenocyte death interferes with clearance through release of DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation or actin scavenger gelsolin. Splenocyte and neutrophil extracellular trap (NET) deficiencies were prevalent individuals COVID-19...
Abstract Background Ferritin is an established biomarker in the diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH), which diagnosed by HLH‐2004 criteria. Among these criteria, detection hemophagocytosis through invasive procedures may delay early life saving treatment. Our aim was to investigate value diagnosing HLH critically ill patients. Methods In this analysis a retrospective observational study, we included all patients aged ≥18 years and admitted any adult ICU at...
Highlights•Incidence of peritoneal metastases in metastatic uveal melanoma (mUM) is 4.27%.•Peritoneal mUM patients have no negative impact on prognosis.•Metastatic pattern with initial extrahepatic spread correlates favorable OS.•Tumor biology reflected by TMB and genetic risk groups determines pattern.•Patients may specifically benefit from ICB.AbstractBackgroundMetastatic an aggressive cancer predominately affecting the liver. Peritoneal (PM) occur rarely, there limited knowledge about...
ABSTRACT Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has caused several hundreds of thousands deaths worldwide. Patients higher age with preexisting chronic health conditions are at an increased risk fatal disease outcome. However, detailed information on causes death contribution comorbidities to yet is missing. Here, we report autopsy findings 26 decedents that had clinically presented severe COVID-19. We found septic shock multi organ failure was...
In coronavirus disease 2019 (COVID-19), the adaptive immune response is of considerable importance, and detailed cellular reactions in hematological system patients with severe acute respiratory syndrome 2 (SARS-CoV-2) infection are yet to be clarified.This study reports morphological characterization both bone marrow spleen 11 COVID-19 decedents respect findings peripheral blood pulmonary SARS-CoV-2 burden.In marrow, activation left shift were found at least 55% patients, which was mirrored...
Inflammatory properties are known to promote tumor progression leading an impaired median overall survival (mOS). Various small studies have focused on a wide range of inflammation-based prognostic indicators. By using sufficient data from 1294 out 2323 patients diagnosed with pancreatic cancer between 2009 and 2021 at our center, inflammatory markers such as the neutrophil lymphocyte ratio (NRL), platelet (PLR), monocyte (LMR) CRP albumin (CAR) were evaluated. We identified new combined...
To investigate the prognostic value of enhancement patterns intrahepatic mass-forming cholangiocarcinomas (IMCCs) during hepatobiliary phase (HBP) in gadoxetic acid (Gd-EOB)-enhanced MRI. We retrospectively identified 66 consecutive patients with histopathologically proven IMCCs (reference standard: resection) and preoperative Gd-EOB-enhanced Gd-EOB retention area was subjectively rated based on areas intermediate signal intensity. Lesions were classified as either hypointense (0-25% area)...
Increased serum ferritin (SF) is common in hematologic malignancies; however, its prognostic role acute myeloid leukemia (AML) not clearly established. We examined the impact of baseline SF on long-term survival 137 intensively treated AML patients. Patients and characteristics were retrieved from an database at Charité University Medical Center Berlin, Campus Virchow Clinic. After c-reactive protein (CRP)-based adjustment for inflammation, patients grouped according to their level. Survival...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing disease 2019 (COVID-19) induces lung injury of varying severity, potentially severe distress (ARDS). Pulmonary patterns in COVID-19 patients differ from those with other causes ARDS. We aimed to explore the frequency and pathogenesis cavitary lesions critically ill COVID-19. Retrospective study 39 adult hospitalized including severity a tertiary care referral center during March May 2020, Berlin/Germany. observed...
Abstract In COVID-19 neurological alterations are noticed during the systemic viral infection. Various pathophysiological mechanisms on central nervous system (CNS) have been suggested in past two years, including neurotropism hypothesis. Nevertheless, complications can also occur independent of and at different stages disease may be persistent. Previous autopsy studies CNS from patients with severe show infiltration macrophages T lymphocytes, especially perivascular regions as well...
ObjectivesStudies on coronavirus disease 2019 (COVID-19) usually focus middle-aged and older adults. However, younger patients may present with severe COVID-19 potentially fatal outcomes. For optimized, more specialized therapeutic regimens in this particular patient group, a better understanding of the underlying pathomechanisms is utmost importance.MethodsOur study investigated relevant, pre-existing medical conditions, clinical histories, autopsy findings, together SARS-CoV-2-RNA,...
Systemic mastocytosis is defined by the clonal proliferation of abnormal mast cells. The clinical course can range from indolent forms with normal life expectancy to advanced cell leukemia dismal prognosis. An association other diseases, including myeloproliferative neoplasia, has been described. We present a case 75-year patient history cutaneous who was diagnosed more than 9 years ago and did not receive treatment. presented our clinic acute kidney failure because renal extramedullary...
Abstract Background The aim of this study was to analyse transcriptomic differences between primary and recurrent high-grade serous ovarian carcinoma (HGSOC) identify prognostic biomarkers. Methods We analysed 19 paired HGSOC samples using targeted RNA sequencing. selected the best candidates in silico survival pathway analysis validated biomarkers immunohistochemistry on a cohort 44 samples, an additional 504 HGSOCs explored their function. Results identified 233 differential expressed...
<title>Abstract</title> Patient-Derived Organoids (PDOs) represent a promising technology for therapy prediction in pancreatic cancer, with the potential of enhancing treatment outcomes and allowing more effective, personalized choices. However, classification approaches into sensitive resistant models remain very variable are based on single-agent testing only, neglecting synergistic effects multi-drug combinations. Here, we established 13 PDOs performed both combinatorial drug testing. By...
To investigate the value of gadoxetic acid (Gd-EOB)-enhanced magnetic resonance imaging (MRI) for noninvasive subtype differentiation HCCs according to 5th edition WHO Classification Digestive System Tumors in a western population.This retrospective study included 262 resected lesions 240 patients with preoperative Gd-EOB-enhanced MRI. Subtypes were assigned by two pathologists. MRI datasets assessed radiologists qualitative and quantitative features, including features defined LI-RADS v2018...
In addition to being risk factors for pancreatic cancer, parameters such as smoking, diabetes, or obesity might also act potential prognostic the survival of patients initially diagnosed with cancer. By implementing one largest retrospective study cohorts 2323 adenocarcinoma (PDAC) treated at a single high-volume center, were evaluated on basis 863 cases. Since obesity, and hypertension can cause severe chronic kidney dysfunction, glomerular filtration rate was considered. univariate...
RGS2 regulates G-protein signaling by accelerating hydrolysis of GTP and has been identified as a potentially druggable target in carcinomas. Since the prognosis patients with high-grade serous ovarian carcinoma (HGSOC) remains utterly poor, new therapeutic options are urgently needed. Previous vitro studies have linked suppression to chemoresistance HGSOC, but situ data still missing. In this study, we characterized expression its relation HGSOC on protein level immunohistochemistry 519...
Abstract Background The detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is challenging, particularly in post-mortem human tissues. However, there increasing evidence for viral SARS-CoV-2 manifestation non-respiratory In this context, it a current matter debate, whether shows hepatotropism. Case presentation Here, we report case an 88-year-old women with massive viremia, jaundice and clinical signs hepatitis, who died within few days from liver failure without showing...