A5066517355- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Cancer Treatment and Pharmacology
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Chemotherapy-related skin toxicity
- Cancer Cells and Metastasis
- Neuroendocrine Tumor Research Advances
- Apelin-related biomedical research
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Zebrafish Biomedical Research Applications
- Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Renin-Angiotensin System Studies
- Biomedical Text Mining and Ontologies
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Nuclear Receptors and Signaling
Humboldt-Universität zu Berlin
2023-2024
Charité - Universitätsmedizin Berlin
2005-2024
Freie Universität Berlin
2023-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2024
University of California, Los Angeles
2018-2020
Max Delbrück Center
2005-2014
Sana Klinikum Lichtenberg
2011
University Hospital of Lausanne
2005
Medizinische Hochschule Hannover
2005
Novartis (Switzerland)
2005
Clinical interpretation of complex biomarkers for precision oncology currently requires manual investigations previous studies and databases. Conversational large language models (LLMs) might be beneficial as automated tools assisting clinical decision-making.
Background— Aldosterone and angiotensin (Ang) II both may cause organ damage. Circulating aldosterone is produced in the adrenals; however, local cardiac synthesis has been reported. concentrations depend on activity of synthase (CYP11B2). We tested hypothesis that reducing by inhibiting CYP11B2 or adrenalectomy (ADX) ameliorate Furthermore, we investigated how much originates from adrenal gland. Methods Results— effect inhibitor FAD286, losartan, consequences ADX transgenic rats...
Pancreatic ductal adenocarcinoma (PDAC) metastasizes by neural, vascular, and local invasion routes, which limit patient survival. In nerves vessels, SLIT2 its ROBO receptors constitute repellent guidance cues that also direct epithelial branching. Thus, the SLIT2-ROBO system may represent a key pinch point to regulate PDAC spread. this study, we examined hypothesis escaping from signaling is essential enable cells appropriate their stromal infrastructure for dissemination. Through...
Abstract Background Surgery represents the only curative treatment option for pancreatic ductal adenocarcinoma (PDAC), but recurrence in more than 85% of patients limits success curative-intent tumor resection. Neural invasion (NI), particularly spread cells along nerves into extratumoral regions pancreas, constitutes a well-recognized risk factor recurrence. Hence, monitoring and therapeutic targeting NI offer potential to stratify improve recurrence-free survival. Based on evolutionary...
Lymphatic metastasis constitutes a critical route of disease dissemination, which limits the prognosis patients with pancreatic ductal adenocarcinoma (PDAC). As lymphangiogenesis has been implicated in stimulation lymphatic by vascular endothelial growth factor-C (VEGF-C) and VEGF-D, we studied effect angioregulatory factor angiopoietin-2 (Ang-2) on PDAC progression. Ang-2 was found to be expressed transformed cells human specimens, corresponding Tie-2 receptors present blood endothelium. In...
Through multiple cell–cell and cell–matrix interactions, epithelial endothelial sheets form tight barriers. Modulators of the cytoskeleton contribute to barrier stability act as rheostats vascular permeability. In this study, we sought identify cytoskeletal regulators that underlie diversity across vessels. To achieve this, correlated functional structural features gene expression cells (ECs) derived from different beds. Within a subset identified candidates, found guanosine nucleotide...
Placental growth factor (PlGF), a VEGF-homolog implicated in tumor angiogenesis and adaptation to antiangiogenic therapy, is emerging as candidate target malignancies. Here, we addressed the expression, function, prognostic value of PlGF neuroendocrine tumors (NETs). was determined NET patients' sera collected retrospectively ( n =88) prospectively =87) using Roche-Elecsys correlated with clinicopathological data. Tumoral evaluated by immunohistochemistry, effects on proliferation migration...
Inflammatory properties are known to promote tumor progression leading an impaired median overall survival (mOS). Various small studies have focused on a wide range of inflammation-based prognostic indicators. By using sufficient data from 1294 out 2323 patients diagnosed with pancreatic cancer between 2009 and 2021 at our center, inflammatory markers such as the neutrophil lymphocyte ratio (NRL), platelet (PLR), monocyte (LMR) CRP albumin (CAR) were evaluated. We identified new combined...
Background: Pancreatic adenocarcinoma (PDAC) is still a complex, devastating disease. Cachexia symptoms frequently impair patient survival. This accompanying syndrome commonly diagnosed late, when clinical signs become evident. Early diagnosis using conventional measurement methods often difficult, and the discrimination of this disease from cancer progression challenging overlaps. The aim study was to analyze whether nutritional assessments or laboratory biomarkers are better predictive...
Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in hemogenic endothelium would yield abnormalities or malignancies. Here, find that endothelium-specific transposon mutagenesis mice promotes pathologies are both myeloid and lymphoid nature. Frequently mutated genes included previously recognized cancer drivers additional candidates, such Pi4ka, a lipid kinase whose mutation was found promote erythroid dysfunction. Subsequent...
In addition to being risk factors for pancreatic cancer, parameters such as smoking, diabetes, or obesity might also act potential prognostic the survival of patients initially diagnosed with cancer. By implementing one largest retrospective study cohorts 2323 adenocarcinoma (PDAC) treated at a single high-volume center, were evaluated on basis 863 cases. Since obesity, and hypertension can cause severe chronic kidney dysfunction, glomerular filtration rate was considered. univariate...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a particularly aggressive disease with few effective treatments. The PDAC tumor immune microenvironment (TIME) is known to be suppressive. Oncolytic viruses can increase immunogenicity via immunogenic cell death (ICD). We focused on tumor‐selective (vvDD) and cytokine‐armed Western‐reserve vaccinia (vvDD‐IL2 vvDD‐IL15) infected carcinoma lines as well patient‐derived primary cells. In co‐culture experiments, we investigated the...
<title>Abstract</title> Patient-Derived Organoids (PDOs) represent a promising technology for therapy prediction in pancreatic cancer, with the potential of enhancing treatment outcomes and allowing more effective, personalized choices. However, classification approaches into sensitive resistant models remain very variable are based on single-agent testing only, neglecting synergistic effects multi-drug combinations. Here, we established 13 PDOs performed both combinatorial drug testing. By...
Metastases largely rely on hematogenous dissemination of tumor cells via the vascular system and significantly limit prognosis patients with solid tumors. To colonize distant sites, circulating must destabilize endothelial barrier transmigrate across vessel wall. Here we performed a high-content screen to identify drugs that block cell extravasation by testing 3,520 compounds transendothelial invasion coculture assay. Hits were further characterized validated using series in vitro assays,...
4128 Background: Placental growth factor (PlGF), a VEGF homolog implicated in tumor angiogenesis and adaptation to antiangiogenic therapy, is emerging as candidate target malignancies. As treatments are introduced the management of neuroendocrine tumors (NETs), we addressed expression function PlGF NETs. Methods: Serum levels were determined two independent cohorts NET patients collected retrospectively prospectively (n=87 n=84) using Roche Elecsys correlated with clinical data. Expression...
<h3></h3> <b>Background:</b> Ewing sarcoma is a rare malignant neoplasm that primarily localized in bone tissues. The prognosis for patients with newly diagnosed has been greatly improved by multimodality treatment. However, treating disseminated or recurrent disease challenging, 5-year overall survival rate of <30%. <b>Case Report:</b> A 17-year-old female an asymptomatic tumor the left temple underwent 3 cycles vincristine, ifosfamide, doxorubicin, and etoposide achieved partial...
We present the rare case of a 51-year-old male diagnosed with solitary fibrous tumor (SFT) prostate, along concurrent low-grade prostate adenocarcinoma (Gleason score 3 + 3, Grade Group 1). The diagnosis was confirmed by positive immunohistochemical markers, including CD34, BCL2, and STAT6, molecular analysis showing NAB2-STAT6 fusion. Following successful surgical management simultaneous pulmonary relapse from prior thyroid carcinoma, patient remains under clinical surveillance. This is...
Einleitung: Slit2 und seine Robo-Rezeptoren sind axon guidance Faktoren mit repulsiver Wirkung auf die Navigation von Nerven Gefäßen. Aufgrund der neuronalen Differenzierung NETs könnte somit das Slit2-Robo Liganden-Rezeptor System eine entsprechend konservierte Funktion bei Regulation Motilität Interaktion Tumorzellen Kompartimenten des Tumormikromilieus spielen.
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) metastasizes by neural, vascular, and local invasion routes, which limit patient survival. In nerves vessels, SLIT2 its ROBO receptors constitute repellent guidance cues that also direct epithelial branching. Thus, the SLIT2–ROBO system may represent a key pinch point to regulate PDAC spread. this study, we examined hypothesis escaping from signaling is essential enable cells appropriate their stromal infrastructure for...
<div>Abstract<p>Metastases largely rely on hematogenous dissemination of tumor cells via the vascular system and significantly limit prognosis patients with solid tumors. To colonize distant sites, circulating must destabilize endothelial barrier transmigrate across vessel wall. Here we performed a high-content screen to identify drugs that block cell extravasation by testing 3,520 compounds transendothelial invasion coculture assay. Hits were further characterized validated...
<div>Abstract<p>Metastases largely rely on hematogenous dissemination of tumor cells via the vascular system and significantly limit prognosis patients with solid tumors. To colonize distant sites, circulating must destabilize endothelial barrier transmigrate across vessel wall. Here we performed a high-content screen to identify drugs that block cell extravasation by testing 3,520 compounds transendothelial invasion coculture assay. Hits were further characterized validated...
<p>AVI file - 2196KB, Recording of unidirectional migration MiaPaCa cells along a contacted neurite from DRG-tumor cell co-culture assay (Example 1).</p>
<p>PDF file - 643KB, Figure S1: Reactivation of Slit2 expression in Panc1 cells by 5-AZA-dC suggests silencing gene due to promoter hypermethylation. S2: inhibits directed migration pancreatic tumor cells. S3: Re-expression does not affect random MiaPaCaTR-Slit2 Cells. S4: Doxycycline treatment results induction protein tumors vivo. S5: Inducible re-expression invasion, metastasis and angiogenesis size-matched orthotopic tumors. S6: Stable knock down Robo1 promotes metastasis, but S7:...
<p>AVI file - 2043KB, Recording of unidirectional migration MiaPaCa cells along a contacted neurite from DRG-tumor cell co-culture assay (Example 2).</p>