A5070853128- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Biomedical Text Mining and Ontologies
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Topic Modeling
Humboldt-Universität zu Berlin
2023-2024
Charité - Universitätsmedizin Berlin
2014-2024
Freie Universität Berlin
2023-2024
Clinical interpretation of complex biomarkers for precision oncology currently requires manual investigations previous studies and databases. Conversational large language models (LLMs) might be beneficial as automated tools assisting clinical decision-making.
Our understanding of oncogenic signaling pathways has strongly fostered current concepts for targeted therapies in metastatic colorectal cancer. The RALA pathway is novel candidate due to its independent role controlling expression genes downstream RAS.We compared GTPase activities three cancer cell lines by pull-down assay and analyzed the transcriptional phenotypic effects transient silencing. Knocking-down diminished active GTP-bound form protein. Proliferation KRAS mutated was...
Adoptive T cell-receptor therapy (ACT) could represent a promising approach in the targeted treatment of epithelial ovarian cancer (EOC). However, identification suitable tumor-associated antigens (TAAs) as targets is challenging. We identified and prioritized TAAs for ACT other immunotherapeutic interventions EOC. A comprehensive list pre-described was created candidates were prioritized, using predefined weighted criteria. Highly ranked immunohistochemically stained tissue microarray 58...
Abstract A patient with gastrointestinal stroma tumor (GIST) and KIT p.V559D BRAF p.G469A alterations was referred to our institutional molecular board (MTB) discuss therapeutic implications. The had been diagnosed B-cell chronic lymphocytic leukemia (CLL) years prior the MTB presentation. GIST 1 month earlier. After structured clinical annotation of interdisciplinary discussion, we considered BRAF/KIT co-mutation unlikely in a treatment-naïve GIST. Discordant variant allele frequencies...
Abstract The EGFR/RAS signaling system plays an imperative role in tumor pathogenesis and therapy response. Downstream effects of the axis are mediated by three major pathway branches: RAF/MAPK, PI3K RALA pathways. While RAF/MAPK pathways have been extensively characterized mechanistic, preclinical clinical studies, RAL is less well understood. Here we compared RALGTPase activities colorectal cancer cell lines active GTPase pull-down assay analyzed transient silencing expression siRNA....