A5021997701- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Monoclonal and Polyclonal Antibodies Research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Galectins and Cancer Biology
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
Comprehensive Cancer Center Vienna
2015-2024
Medical University of Vienna
2015-2024
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2019-2024
Tsinghua University
2015-2019
Center for Life Sciences
2019
University of Kentucky
2014-2016
Ludwig Boltzmann Cluster for Cardiovascular Research
2011-2016
Markey Cancer Center
2014-2015
Erasmus MC Cancer Institute
2015
The Graduate Center, CUNY
2014
Abstract Background MicroRNAs are a class of small, non-coding RNAs that regulate gene expression by binding target mRNA, which leads to cleavage or translational inhibition. The NAC proteins, include NAM, ATAF, and CUC, plant-specific transcription factor family with diverse roles in development stress regulation. It has been reported miR164 negatively regulates NAC1 expression, turn affects lateral root Arabidopsis ; however, little is known about the involvement maize development. Results...
Resistance to platinum-based chemotherapy is a common event in patients with cancer, generally associated tumor dissemination and metastasis. Whether platinum treatment per se activates molecular pathways linked spreading not known. Here, we report that the ubiquitin-specific protease 1 (USP1) mediates ovarian cancer cell resistance platinum, by regulating stability of Snail, which, turn, promotes dissemination. At level, observed upon treatment, USP1 phosphorylated ATM ATR binds Snail....
Abstract Purpose: Genetic polymorphisms of cytokine-encoding genes are known to predispose malignant disease. Interleukin (IL)-1 and IL-6 crucially involved in breast carcinogenesis. Whether the encoding IL-1 (IL1) (IL6) also influence cancer risk is unknown. Experimental Design: In present case-control study, we ascertained three IL1 gene cluster [−889 C/T polymorphism IL1α (IL1A), −511 IL1β promoter (IL1B promoter), a exon 5 5)], an 86-bp repeat intron 2 receptor antagonist (IL1RN), −174...
The presence of circulating tumor cells (CTC) in the peripheral blood cancer patients has been described for various solid tumors and their clinical relevance shown. CTC detection based on analysis epithelial antigens might be hampered by genetic heterogeneity primary loss antigens. Therefore, we aimed to identify new gene markers PCR-based female patients.Gene expression 38 cell lines (breast, ovarian, cervical endometrial) 10 mononuclear (PBMC) samples from healthy donors was measured...
<h3>Objective</h3> The objective of the study was to evaluate prognostic impact residual tumor size after cytoreductive surgery in patients with epithelial ovarian cancer. <h3>Methods</h3> In this prospective, multicenter study, 226 cancer (International Federation Gynecology and Obstetrics stages IIA–IV) were included. Patients treated adjuvant platinum-based chemotherapy. Univariate multivariable survival analyses performed investigate on progression-free overall survival. <h3>Results</h3>...
Cytoplasmic male sterility (CMS) is a widespread phenomenon in higher plants, and several studies have established that this maternally inherited defect often associated with mitochondrial mutant.Approximately 10 chimeric genes been identified as being corresponding CMS systems the family Brassicaceae, but there little direct evidence these cause sterility.In study, novel gene (named orf288) was found to be located downstream of atp6 co-transcribed hau sterile line.Western blotting analysis...
DNA damage repair can lead to epigenetic changes. mismatch proteins bind platinum adducts and at sites of recruit the methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that during platinum-based chemotherapy may cause methylation normal tissues patients such as blood.
Significance DNA replication accuracy is critical for genetic stability and ensured by high-fidelity replicative polymerases the mismatch repair (MMR) system, both of which are regulated proliferating cell nuclear antigen (PCNA). Dysfunction either system leads to genome instability cancer development. Interestingly, many types cancers have no obvious defects in but they display increased mutation frequency during The underlying mechanism unknown. We demonstrate here that PCNA tyrosine...
Kruppel-like factor (KLF5) is a cell growth mediator in various epithelial cells. Higher KLF5 increases rate and leads to transformed phenotypes. Because tumor proliferation tightly associated with progression, consequently, survival of cancer patients, we wanted examine the prognostic value gene expression for patients breast cancer.The levels KLF5, ER, PR, HER2, MKI67 were quantified tissues 90 correlated disease-free overall patients. The correlations between analyzed. In addition, was...
Mutations in the KRAS gene are one of most frequent genetic abnormalities ovarian carcinoma. They renewed interest as new epidermal growth factor receptor (EGFR)-targeted therapies being investigated for use As mutations associated with poor response and resistance to EGFR-targeting drugs, this study was conducted obtain more information on spectrum The presence codon 12 13 analyzed frozen formalin-fixed paraffin-embedded (FFPE) tissue a low density biochip platform. 381 malignant (29...
Abstract Purpose: We aimed to determine the clinical role of p53 family members and p73 in responsiveness platinum-based chemotherapy survival ovarian cancer, considering their cross-talk polymorphism at codon 72. Experimental Design: A detailed analysis a series 122 cancers was done. used functional yeast-based assay mutational status. Red yeast colonies, indicating mutant p53, were subsequently sequenced specific alteration. mutations divided into two groups according previous...
Abstract Background Epithelial ovarian cancer is one of the most lethal gynecologic malignancies. Clinicopathological factors do not permit precise prognosis and cannot provide guidance to specific treatments. In this study we assessed tumor infiltrating CD8+ T cells in association with Ki67 proliferation index evaluated their prognostic impact EOC samples. Methods were immunohistochemically determined on tissue microarrays including 203 primary epithelial tumors. Additionally, CD8 gene...
Most patients with epithelial ovarian cancer (EOC) are diagnosed at advanced stage and have a poor prognosis. However, small proportion of these will survive, whereas others die very quickly. Clinicopathological factors do not allow precise identification subgroups. Thus, we validated molecular subclassification as new prognostic factor in EOC. One hundred ninety-four Stage II-IV EOC were characterized by whole-genome expression profiling tumor tissues classified using published 112 gene...