A5056919380- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- Iron Metabolism and Disorders
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Colorectal Cancer Treatments and Studies
- Gastrointestinal motility and disorders
- Genetic factors in colorectal cancer
- Animal Disease Management and Epidemiology
- Hemoglobinopathies and Related Disorders
- Lipoproteins and Cardiovascular Health
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Animal Virus Infections Studies
- Cholesterol and Lipid Metabolism
- Nutrition, Genetics, and Disease
- Viral gastroenteritis research and epidemiology
- Vitamin D Research Studies
- Amino Acid Enzymes and Metabolism
- Molecular Biology Techniques and Applications
- SARS-CoV-2 detection and testing
Yerevan State Medical University
2024
Medical Diagnostic Laboratories (United States)
2024
University of Applied Sciences BFI Vienna
2022
Medical University of Graz
2016-2021
Engineering Software Steyr (Austria)
2015-2019
Novosibirsk State Medical University
2019
Cukurova University
2018-2019
Ludwig Boltzmann Institute Applied Diagnostics
2014
Tbilisi State Medical University
2014
Ludwig Boltzmann Gesellschaft
2012
Abstract Introduction Recently several diagnostic manufacturers have launched new 25-hydroxy-vitamin D (25[OH]D) assays, which are aligned to the National Institute of Standards and Technology (NIST) Standard Reference Materials (SRM) (NIST, Gaithersburg, Maryland). The aim this study was compare performance one liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, enzyme linked immunosorbent assay (ELISA), recalibrated previous version a chemiluminescence immunoassay (CLIA)....
So far, studies on possible association of plasma lipid levels and depressive disorder are contradictory. This prospective work aimed at assessing a profile in individuals with major depression healthy controls.In total, 94 patients 152 controls were included this study. After an overnight fasting state 12 h they underwent blood drawing for triglyzerides (TG), total cholesterol, low-density lipoprotein (LDL)- high-density (HDL)-cholesterol measurements. All participants evaluated clinical...
Mutations in the KRAS gene are one of most frequent genetic abnormalities ovarian carcinoma. They renewed interest as new epidermal growth factor receptor (EGFR)-targeted therapies being investigated for use As mutations associated with poor response and resistance to EGFR-targeting drugs, this study was conducted obtain more information on spectrum The presence codon 12 13 analyzed frozen formalin-fixed paraffin-embedded (FFPE) tissue a low density biochip platform. 381 malignant (29...
Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and paired x lymph node metastasis may elucidate potential role of molecular targeted therapy advanced stages. BRAF NRAS PTC (n = 253) with corresponding metastatic 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 a p-value <0.05, concordance via kappa agreement. mutation frequency conventional (cPTC): 56.8%, microcarcinoma (PTMC):...
Congenital adrenal hyperplasia (CAH) due to CYP21A2 gene mutations is associated with a variety of clinical phenotypes (salt wasting, SW; simple virilizing, SV; nonclassical, NC) depending on residual 21-hydroxylase activity. Phenotypes and genotypes correlate well in 80-90% cases. We set out test the predictive value CAH phenotype assignment based genotype classification large multicenter cohort. A retrospective evaluation genetic data from 538 patients (195 screened) collected 28 tertiary...
Abstract Background Anastrozole is a selective aromatase inhibitor used for the treatment of postmenopausal hormone‐sensitive breast cancer. The major side effects include osteoporosis, hypercholesterolemia, and musculoskeletal events, such as arthralgia myalgia. Other adverse events are rare, including symptoms acne, masculinization, drug‐induced liver injury, with latter reported in few cases only. Case Here, we report on patient under anastrozole therapy who developed injury assessed by...
In addition to the previously identified 4-α-glucanotransferase gene mgtA and α-amylase amyA of Thermotoga maritima strain MSB8 we have now isolated three further genes encoding amylolytic enzymes from a library this ancestral bacterium. The code for extremely thermostable pullulanase (pulA), maltodextrin phosphorylase (agpA) α-glucosidase (aglA) potential encode polypeptides with calculated molecular masses 96.3 kDa, 96.1 kDa 52.5 respectively. Comparative amino acid sequence analysis...
The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total 439 outpatients, who presented unclear abdominal discomfort, underwent (50 g) (25 hydrogen (H 2 ) breath tests. Additionally, serum diamine oxidase (DAO) measurements were performed. Individuals low DAO activity (<10 U/mL), GI symptoms, response...
As hepcidin-25 is considered as a key regulator of human iron homoeostasis, this study aimed to compare parameter with conventional biomarkers and diagnostic tools deficiency (ID).In total, 233 hospitalised adult patients, who underwent routine blood testing for ID, were included. All subjects investigated hepcidin-25, reticulocyte haemoglobin content (CHr), soluble transferrin receptor (sTfR)/log ferritin ratio (i.e. Thomas plot), sTfR, ferritin, saturation (TSAT), C-reactive protein (CRP)...
To assess the roles of genetic modifiers in Iraqi β-thalassemia patients, and determine whether a genotype-based scoring system could be used to predict phenotype, total 224 patients with molecularly characterized homozygous or compound heterozygous were further investigated for α-thalassemia deletions as well five polymorphisms namely: rs7482144 C > T at HBG2, rs1427407 G rs10189857 A BCL11A, rs28384513 rs9399137 HMIP. The enrolled had median age 14 years, 96 males 128 females. They...
Abstract Background Proto‐oncogene B‐Raf (BRAF) mutation rates have been reported in nevi and melanomas of homogeneous Caucasian cohorts. Objective To study the demographics BRAF mutations dysplastic populations with differing potential solar UV radiation exposure. Methods Extended testing for 9 125 from 101 patients, derived exposure (Lebanon Saudi Arabia), was performed. Clinical microscopic parameters were recorded. Results status carried out 101/125 (80.8%) cases an overall rate 62.4%...