Susanne Bengesser
A5049569257- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Adolescent and Pediatric Healthcare
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Genetic Associations and Epidemiology
- COVID-19 and Mental Health
- Gut microbiota and health
- Eating Disorders and Behaviors
- Diet and metabolism studies
- Schizophrenia research and treatment
- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
- Digital Mental Health Interventions
- Electroconvulsive Therapy Studies
- Sleep and related disorders
- Vitamin D Research Studies
- Child Nutrition and Feeding Issues
- Personality Disorders and Psychopathology
- Circadian rhythm and melatonin
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychoanalysis and Social Critique
- Psychiatric care and mental health services
- Long-Term Effects of COVID-19
Medical University of Graz
2016-2025
Genomics (United Kingdom)
2022
University of Münster
2022
Max Planck Institute of Psychiatry
2021
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2013-2018
University of Graz
2014
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
There is evidence that the gut microbiota plays a major role in pathogenesis of diseases central nervous system through gut-brain axis. The aim present study was to analyze composition bipolar disorder (BD) and its relation inflammation, serum lipids, oxidative stress, tryptophan (TRP)/kynurenine (KYN) levels, anthropometric measurements parameters metabolic syndrome. Further, microbial community differences individuals with BD compared healthy controls (HC) were explored.In this...
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
Gut microbiota are suspected to affect brain functions and behavior as well lowering inflammation status. Therefore, an effect on depression has already been suggested by recent research. The aim of this randomized double-blind controlled trial was evaluate the probiotic treatment in depressed individuals. Within inpatient care, 82 currently individuals were randomly assigned either receive a multistrain plus biotin or placebo for 28 days. Clinical symptoms gut microbiome analyzed at begin...
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action incompletely understood, and prediction outcomes limited. In our previous multi-omics study Pharmacogenomics Bipolar Disorder (PGBD) sample combining transcriptomic genomic data, we found that focal adhesion, extracellular matrix (ECM), PI3K-Akt signaling networks were associated with response to lithium. this study, replicated results using network propagation methods in a genome-wide...
Individuals with bipolar disorder (BD) are disproportionately affected by symptoms of being overweight and metabolic syndrome when compared to the general population. The pertinence this observation is underscored observations that excess weight associated a more complex illness presentation, course, outcome in BD. We present first preliminary report our BIPFAT study, which explored shared hypothesized pathophysiological pathways between having BD.We investigated tryptophan-kynurenine...
Introduction Bipolar disorder (BD) is a chronic psychiatric disease which can take most different and unpredictable courses. It accompanied by unspecific brainstructural changes cognitive decline. The neurobiological underpinnings of these processes are still unclear. Emerging evidence suggests that tryptophan catabolites (TRYCATs), involve all metabolites towards the kynurenine (KYN) branch, involved in etiology as well course BD. They proposed to be mediators immune-inflammation...
Major depressive disorder (MDD) is a prevalent disease, in which one third of sufferers do not respond to antidepressants. Probiotics have the potential be well-tolerated and cost-efficient treatment options. However, molecular pathways their effects are fully elucidated yet. Based on previous literature, we assume that probiotics can positively influence inflammatory mechanisms. We aimed at analyzing gene expression inflammation genes as part randomized, placebo-controlled, multispecies...
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health that affects about 1% of population worldwide. Nevertheless, lithium not consistently effective, with only 30% patients showing favorable response to treatment. To provide personalized options patients, it essential identify prediction biomarkers such polygenic scores. In this study, we developed score (Li + PGS ) in BD. gain further insights into lithium’s possible...
Abstract The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we performed exploratory study the contributions immune-relevant genetic factors to response lithium (Li) treatment clinical presentation BP. First, assessed association large collection immune-related genes (4925) with Li response, defined by...
Objectives. Overweight/obesity has been implicated to play a role in cognitive deficits bipolar disorder (BD). This study aims identify the relationship between body fat distribution and different domains of cognition BD during euthymia. Methods. A sample 100 euthymic individuals with was measured test battery (i.e., Trail Making Test-A-B/TM-A/B, d2 Test Attention, Stroop test, California Verbal Learning Test/CVLT) an anthropometric measures set (body mass index, waist circumference, hip...
The clock gene ARNTL is associated with the transcription activation of monoamine oxidase A according to previous literature. Thus, we hypothesised that methylation may differ between bipolar disorder (BD) and controls.The status one CpG island covering first exon (PS2) site in 5' region (cg05733463) were analysed patients BD (n = 151) versus controls 66). Methylation analysis was performed by bisulphite-conversion DNA from fasting blood EpiTect Bisulfite Kit, PCR pyrosequencing. Analysis...
Background Studying phenotypic and genetic characteristics of age at onset (AAO) polarity (PAO) in bipolar disorder can provide new insights into disease pathology facilitate the development screening tools. Aims To examine architecture AAO PAO their association with characteristics. Method Genome-wide studies (GWASs) polygenic score (PGS) analyses ( n = 12 977) 6773) were conducted patients from 34 cohorts a replication sample 2237). The was investigated two these cohorts. Results Earlier...
Background: Metabolic syndrome (MetS) is more prevalent in individuals with bipolar disorder and has a negative impact on cognition, particular executive function, which already impaired compared to healthy controls. Methods: In cross-sectional study, we 148 euthymic patients 117 controls cognitive function depending the diagnosis of MetS. A neuropsychological test battery was used including Trail Making Test A/B, Stroop Color Word Interference Test, d2 Attention Revised, California Verbal...
Abstract Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part holistic concepts. About half patients do not take their medication regularly, although adherence can prevent exacerbations re-hospitalizations. To date, relationship between cognitive performance is understudied. Therefore, this study investigated by analyzing data 862 participants with schizophrenia-spectrum disorders (mean [SD] age, 41.9 [12.48] years;...