J. Raymond DePaulo
A5064779022- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Adolescent and Pediatric Healthcare
- Genomic variations and chromosomal abnormalities
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Treatment of Major Depression
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Tryptophan and brain disorders
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Mental Health and Psychiatry
- Suicide and Self-Harm Studies
- Mental Health Research Topics
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Genetic Neurodegenerative Diseases
- Autism Spectrum Disorder Research
- Cardiomyopathy and Myosin Studies
- BRCA gene mutations in cancer
- Genomics and Rare Diseases
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2012-2025
University of Michigan–Ann Arbor
2005-2020
University of Iowa
2020
Mayo Clinic in Florida
2020
Johns Hopkins Hospital
1982-2017
Emory University
2017
National Institute of Mental Health
1996-2005
Stanley Medical Research Institute
2005
Dana Foundation
2005
Objective: Although many investigators have studied mood disorders following myocardial infarction, the prevalence, severity, and persistence of depression been disputed, standard rating scales criteria for depressive infrequently utilized. The authors' goal was to determine how frequently occur after investigate predisposing factors such disorders. Method: Structured clinical interviews were administered 129 inpatients within ten days infarction. Patients also evaluated using standardized...
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
Abstract The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference supporting genomic analyses through semantic similarity machine learning algorithms. HPO has widespread applications in clinical diagnostics translational research, including diagnostics, gene-disease discovery, cohort analytics. In recent years, groups around world have developed translations from English...
<h3>Background:</h3> A prior positron emission tomographic study from The Johns Hopkins University, Baltimore, Md, using<i>N</i>-methylspiperone labeled with carbon 11 reported elevated basal ganglia D<sub>2</sub>dopamine receptor density (B<sub>max</sub>) values in neuroleptic-naive schizophrenic patients compared controls. We have now extended these studies to include bipolar disorder. <h3>Methods:</h3> Patients disorder (n=14) either had never received neuroleptic medication or been...
A report on an initial genome screen 540 individuals in 97 families was collected as part of the NIMH Genetics Initiative Bipolar Disorder. Families were ascertained to be informative for genetic linkage and underwent a common ascertainment assessment protocol at four clinical sites. The sample genotyped 65 highly polymorphic markers from chromosomes 1, 6, 8, 10, 12. average intermarker interval 16 cM. Genotypic data analyzed using affected sib pair, multipoint pedigree analysis methods....
OBJECTIVE: To assess whether age at onset variation reflects underlying genetic heterogeneity in bipolar disorder, the authors examined clinical and familial characteristics of disorder subjects from families with multiple affected members. METHOD: A total 211 1,856 were ascertained through I probands. All assessed Diagnostic Interview for Genetic Studies assigned diagnoses by trained clinicians using best estimate procedures. Admixture analysis probands was used to decompose age-at-onset...
Abstract The Mini‐Mental State and General Health Questionnaire were used to detect cognitive defects emotional disturbances, respectively, in 126 consecutively admitted neurological patients. was revalidated this sample as a measure related cerebral disorder. Sixty‐seven percent of the patients tested had defect, disturbance, or both. Thirty with psychiatric disturbance not recognized by their physician. majority disturbances persisted at time discharge. Since are common among inpatients...
Computerized axial tomography (CAT) scans were blindly examined, and lateral ventricular-to-brain ratios calculated in 19 schizophrenic 27 bipolar patients, an equal number of individually matched normal controls. Family history, early development, past psychiatric current functioning symptomatology analyzed for all patients. Lateral ventricular enlargement on CAT was found a significant proportion both patient groups. Patients with such tended to have greater numbers negative symptoms...