Maria Grigoroiu‐Serbânescu
A5027599458- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Adolescent and Pediatric Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Genomic variations and chromosomal abnormalities
- Suicide and Self-Harm Studies
- Epigenetics and DNA Methylation
- Eating Disorders and Behaviors
- Child Nutrition and Feeding Issues
- Maternal Mental Health During Pregnancy and Postpartum
- Personality Disorders and Psychopathology
- Attention Deficit Hyperactivity Disorder
- Family Support in Illness
- Obsessive-Compulsive Spectrum Disorders
- Genomics and Rare Diseases
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- Child Therapy and Development
- Immune Cell Function and Interaction
- Cognitive Abilities and Testing
- Infant Development and Preterm Care
- Tryptophan and brain disorders
- Psychotherapy Techniques and Applications
Spitalul Clinic de Psihiatrie Alexandru Obregia
2016-2025
University of Utah
2023
Virginia Commonwealth University
2019-2023
Huntsman (United States)
2023
Icahn School of Medicine at Mount Sinai
2019-2023
Genomics (United Kingdom)
2022
State University of New York
2019
Massachusetts General Hospital
2019
University of Bucharest
2005
Clinical Emergency Hospital Bucharest
1998-2000
Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length treatment, unpredictable clinical course, and often inconsistent compliance. Prospective retrospective methods have been proposed the literature. In this study we report key phenotypic measures “Retrospective Criteria Long-Term Treatment Response Research Subjects with Bipolar Disorder” scale currently used Consortium on Lithium Genetics (ConLiGen) study. Materials...
Abstract Borderline personality disorder (BOR) is determined by environmental and genetic factors, characterized affective instability impulsivity, diagnostic symptoms also observed in manic phases of bipolar (BIP). Up to 20% BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) BOR, performed one largest BOR patient samples worldwide. The focus our analysis was (i) detect genes gene sets involved (ii) investigate overlap...
Abstract Objective: The course and clinical predictors of rehospitalization were studied in a large sample adolescent patients with anorexia nervosa who had been treated at five European sites followed‐up. Method: Two‐hundred twelve first admitted for in‐patient treatment, aged 10–18 (Mean 14.9) years 94.8% female, followed‐up an average 8.3 after admission (former East West Berlin, Zurich, Sofia, Bucharest). Clinical history data collected by use standardized item‐sheets admission....
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action incompletely understood, and prediction outcomes limited. In our previous multi-omics study Pharmacogenomics Bipolar Disorder (PGBD) sample combining transcriptomic genomic data, we found that focal adhesion, extracellular matrix (ECM), PI3K-Akt signaling networks were associated with response to lithium. this study, replicated results using network propagation methods in a genome-wide...
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological remain largely unknown. A recent SCZ genome wide association study (GWAS) the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). present...
Abstract Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric with lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, class small noncoding RNAs, contribute to basic mechanisms underlying brain development plasticity, suggesting their possible involvement in pathogenesis several psychiatric disorders, including BD. In present...
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health that affects about 1% of population worldwide. Nevertheless, lithium not consistently effective, with only 30% patients showing favorable response to treatment. To provide personalized options patients, it essential identify prediction biomarkers such polygenic scores. In this study, we developed score (Li + PGS ) in BD. gain further insights into lithium’s possible...
Abstract The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we performed exploratory study the contributions immune-relevant genetic factors to response lithium (Li) treatment clinical presentation BP. First, assessed association large collection immune-related genes (4925) with Li response, defined by...
Background Studying phenotypic and genetic characteristics of age at onset (AAO) polarity (PAO) in bipolar disorder can provide new insights into disease pathology facilitate the development screening tools. Aims To examine architecture AAO PAO their association with characteristics. Method Genome-wide studies (GWASs) polygenic score (PGS) analyses ( n = 12 977) 6773) were conducted patients from 34 cohorts a replication sample 2237). The was investigated two these cohorts. Results Earlier...
Abstract Gene identification in common disorders such as Alzheimer disease and breast cancer has greatly profited from the use of age onset criterion to delineate subgroups characterized by different inheritance patterns. In bipolar affective disorder, where majority linkage studies have produced conflicting results, reporting clinical characteristics familial occurrence suggested that might serve an indicator for identifying more homogeneous disease. Our study was first examine this...
Serotonin type 3 receptors (5-HT3) are involved in learning, cognition and emotion, have been implicated various psychiatric phenotypes. However, their contribution to the pathomechanism of these disorders remains elusive. Three single nucleotide polymorphisms (SNPs) HTR3A HTR3B genes (rs1062613, rs1176744 rs3831455) associated with bipolar affective disorder (BPAD) pilot studies, all them functional relevance. We performed a European multicenter study confirm previous results provide...
Background Response to lithium in patients with bipolar disorder is associated clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which will respond treatment. Aims To use a factors response disorder. Method This study utilised data ( n = 1034) collected as part the International Consortium on Lithium Genetics (ConLi + Gen) project. Polygenic risk scores (PRS) were computed for schizophrenia major depressive...
Abstract Two recent studies reported evidence for association between genetic variation of the positional candidate gene P2RX7 on chromosome 12q24 and bipolar I disorder (BPI) [Barden et al. ( 2006 ); Am J Med Genet Part B 141B:374–382; McQuillin 2008 Mol Psychiatry 13:1‐7] one study found with unipolar major depression (Mdd‐UP) [Lucae Hum 15:2438–2445]. In present work, we aimed to replicate SNP that showed strongest in above‐mentioned studies, namely rs2230912 (P2RX7‐E13A) resulting a...