A5086490615- Personality Disorders and Psychopathology
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Attachment and Relationship Dynamics
- Bipolar Disorder and Treatment
- Suicide and Self-Harm Studies
- Psychiatric care and mental health services
- Breastfeeding Practices and Influences
- Genetic Syndromes and Imprinting
- Neuroendocrine regulation and behavior
- Pediatric Pain Management Techniques
- Stress Responses and Cortisol
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Personality Traits and Psychology
- Autism Spectrum Disorder Research
- Infant Health and Development
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Blood groups and transfusion
- Health Literacy and Information Accessibility
- Healthcare Decision-Making and Restraints
- Air Quality and Health Impacts
- Neuroethics, Human Enhancement, Biomedical Innovations
- Maternal and Perinatal Health Interventions
Heidelberg University
2017-2024
Central Institute of Mental Health
2021
Johannes Gutenberg University Mainz
2012-2015
University Medical Center of the Johannes Gutenberg University Mainz
2012-2015
Universität Trier
2012-2015
University Hospital and Clinics
2014
University Medical Center
2014
University of Applied Sciences Mainz
2012
University Hospital Bonn
2001
Abstract Borderline personality disorder (BOR) is determined by environmental and genetic factors, characterized affective instability impulsivity, diagnostic symptoms also observed in manic phases of bipolar (BIP). Up to 20% BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) BOR, performed one largest BOR patient samples worldwide. The focus our analysis was (i) detect genes gene sets involved (ii) investigate overlap...
Both environmental (e.g. interpersonal traumatization during childhood and adolescence) genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in general population indicate that underlying these are shared part with traits Five Factor Model (FFM) personality-the "Big Five". In present study, overlap BPD Big -Openness Experience, Conscientiousness, Extraversion, Agreeableness, Neuroticism-...
Borderline personality disorder (BPD) is characterized by a pattern of intense but unstable interpersonal relationships. These dysfunctions may originate from impaired bonding and attachment that determined during early life. Remarkably, it has been reported the quality mother-infant relationship influenced feeding mode. Thus, bottle instead breastfeeding possible lack maternal bonding-related behavior increase risk for later psychopathology problems as seen in BPD. A total 100 BPD patients...
The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar (BD) share genetic variation through analysis known risk factors for BD in a well-characterized BPD case–control cohort. Genotyping five genome-wide significant variants identified (in CACNA1C, ANK3, ODZ4) performed 673 cases 748 controls. A nominally association with found rs1006737 CACNA1C (P=0.0498). Sex-specific showed signal present only women. This is first report an...
Patients with borderline personality disorder (BPD) show a high prevalence of early adversity, such as childhood trauma. It has also been reported that prenatal adverse conditions, maternal stress, drug taking, tobacco smoking or medical complications, may be associated an increased risk mental disorders in the offspring. Prenatal adversity is investigated here for first time potential factor diagnosis BPD. Method A total 100 patients DSM-IV BPD and matched healthy controls underwent...
Little is known regarding characteristics of subjects using substances exclusively for the purpose pharmacological neuroenhancement (PN). Aim this pilot study was to characterize students in Germany who use methylphenidate (MPH) and/or amphetamines (AMPH) PN.Semi-structured interviews among 20 reported MPH/AMPH PN and matched controls.Subjects stimulants had significant better knowledge about further illicit than controls. Users AMPH more frequently used MPH users. Regarding prescription no...
Loneliness, influenced by genetic and environmental factors such as childhood maltreatment, is one aspect of interpersonal dysfunction in Borderline Personality Disorder (BPD). Numerous studies link loneliness BPD twin indicate a contribution to this association. The aim our study was investigate whether predisposition for risk overlap contributes higher reported patients, using genome-wide genotype data. We assessed the correlation association (GWAS) linkage disequilibrium score regression...
Zusammenfassung Mit dem Gesetz zur Reform der Führungsaufsicht 2007 wurde forensische Nachsorge sowohl für ehemalige Patienten aus Maßregelvollzug als auch Straffällige Justizvollzug verbindlich etabliert. Im Lauf vergangenen zehn Jahre entstanden somit bundesweit Ambulanzen des Strafvollzugs, welche den gesetzlichen Auftrag zu Behandlung und Betreuung entlassener Straffälliger länderspezifisch umsetzen. Hierbei handelt es sich teils um neu gegründete Ambulanzen, bereits lange in von...
Background Postpartum depression (PPD) is a severe mental disorder that often results in poor maternal-infant attachment and negatively impacts infant development. Universal screening has recently been recommended to identify women at risk, but the optimal time during pregnancy not defined so far. Thus, web-based technologies with widespread use among of childbearing age create new opportunities detect pregnancies high risk for adverse health outcomes an early stage. Objective The aim this...
Abstract Background Pregnancy and childbirth are critical life events which lead to significant changes in family structures roles, thus having a substantial impact on partner relationship maternal wellbeing. A dysfunctional partnership during this time of has been associated with depressiveness. However, sub-components quality the causal relation symptoms depression perinatal period have sparsely studied so far. The current study aims longitudinally assess course its from pregnancy...
Abstract Environmental and genetic risk factors contribute to the development of borderline personality disorder (BPD). We conducted largest GWAS BPD date, meta-analyzing data from 12,339 cases 1,041,717 controls European ancestry, identified six independent associated genomic loci, nine genes in gene-based analysis. observed a single-nucleotide polymorphism (SNP) heritability 17.3% derived polygenic scores (PGS) predicted 4.6% phenotypic variance case-control status. showed strongest...
Abstract Loneliness, influenced by genetic and environmental factors such as childhood maltreatment, is one aspect of interpersonal dysfunction in Borderline Personality Disorder (BPD). Numerous studies link loneliness BPD twin indicate a contribution to this association. The aim our study was investigate whether predisposition for risk overlap contributes higher reported patients, using genome-wide genotype data. We assessed the correlation association (GWAS) linkage disequilibrium score...
Introduction Perinatal depression (PND) is a frequently observed mental disorder, showing prevalence of up to 20% and resulting in unfavorable maternal neonatal outcomes. Targeted screening for PND offers the potential identify treat undiagnosed cases help prevent its deleterious consequences. The aim present study was evaluate participants' personal attitudes acceptance routine program pregnancy care, any underlying factors, appraise general perspective on perinatal health problems. Methods...
Patienten mit Epilepsie weisen häufig kognitive Dysfunktionen auf, die bedeutsam den Alltag beeinträchtigen können. Bei Routineuntersuchungen werden diese Störungen in der Regel nicht erfasst, und Screeningverfahren für deutschsprachigen Raum existieren bislang nicht. Mit dem neu entwickelten „Episcope“ steht nun ein Screeninginstrument zur Verfügung, mithilfe dessen bei Epilepsiepatienten typischerweise auftretenden neuropsychologischen ökonomisch erfasst
Abstract Both environmental (e.g. interpersonal traumatization during childhood and adolescence) genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in general population indicate that underlying these are shared part with traits Five Factor Model (FFM) – “Big Five". In present study, overlap BPD Big -Openness Experience, Conscientiousness, Extraversion, Agreeableness Neuroticism- was...