A5007964297- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Hypothalamic control of reproductive hormones
- Gene expression and cancer classification
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Fibroblast Growth Factor Research
- Bioinformatics and Genomic Networks
- Adrenal Hormones and Disorders
- Chemical Synthesis and Analysis
- Genetics and Neurodevelopmental Disorders
University of Michigan
2016-2025
Üsküdar University
2025
Istanbul Medipol University
2025
Neurosciences Institute
2013-2019
Massachusetts General Hospital
2019
American Academy of Arts and Sciences
2018
Michigan United
2009-2017
Hope for Depression Research Foundation
2017
Neuroscience Institute
2005-2015
Stanford University
1977-2015
Genome-wide expression profiling is a powerful tool for implicating novel gene ensembles in cellular mechanisms of health and disease. The most popular platform genome-wide the Affymetrix GeneChip. However, its selection probes relied on earlier genome transcriptome annotation which significantly different from current knowledge. resultant informatics problems have profound impact analysis interpretation data. Here, we address these critical issues offer solution. We identified several...
The N -methyl-D-aspartate (NMDA) subtype of the glutamate receptor is an important mediator several forms neural and behavioral plasticity. present studies examined whether NMDA receptors might be involved in development opiate tolerance dependence, two examples noncompetitive antagonist MK-801 attenuated to analgesic effect morphine without affecting acute analgesia. In addition, dependence as assessed by naloxone-precipitated withdrawal. These results suggest that may dependence.
Abstract The μ, δ, and κ opioid receptors are the three main types of round in central nervous system (CNS) periphery. These peptides with which they interact important a number physiological functions, including analgesia, respiration, hormonal regulation. This study examines expression receptor mRNAs rat brain spinal cord using situ hybridization techniques. Tissue sections were hybridized 35 S‐labeled cRNA probes to μ (744–1, 064 b), δ (304–1,287 (1,351–2,124 b) receptors. Each mRNA...
Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving other sensory modes relatively unaffected. The peripheral field of analgesia was usually restricted one-half or one quadrant the body, painful stimuli applied outside this elicited a normal reaction. Analgesia outlasted stimulation by up 5 minutes. Most electrode placements that produced also supported self-stimulation. One placement self-stimulation only presence pain.
Analgesia produced by focal electrical stimulation of the brain is partially reversed narcotic antagonist naloxone. The absence complete reversal does not appear to be caused inadequate doses naloxone since higher than 1 milligram per kilogram body weight did increase antagonism. It suggested that stimulation-produced analgesia may result, at least in part, from release an endogenous, narcotic-like substance, such as recently reported other investigators.
Abnormalities in l -glutamic acid (glutamate) and GABA signal transmission have been postulated to play a role depression, but little is known about the underlying molecular determinants neural mechanisms. Microarray analysis of specific areas cerebral cortex from individuals who had suffered major depressive disorder demonstrated significant down-regulation SLC1A2 SLC1A3, two key members glutamate/neutral amino transporter protein family, SLC1. Similarly, expression -glutamate-ammonia...
A cardinal symptom of major depressive disorder (MDD) is the disruption circadian patterns. However, to date, there no direct evidence clock dysregulation in brains patients who have MDD. Circadian rhythmicity gene expression has been observed animals and peripheral human tissues, but its presence variability brain were difficult characterize. Here, we applied time-of-death analysis data from high-quality postmortem brains, examining 24-h cyclic patterns six cortical limbic regions 55...
Several lines of evidence suggest the existence multiple dopamine receptor subtypes, referred to as D1 and D2. The present study examines distribution these binding sites in rat brain pituitary relation D2 mRNA using a combination vitro autoradiographic situ hybridization techniques. 3H-Raclopride 3H-SCH23390 (in presence 1 microM ketanserin) were used label sites, respectively, while 495 bp cRNA probe synthesized from Sac I-Bgl II fragment cDNA was visualize mRNA. Analysis adjacent tissue...
Expression of mRNAs coding for the ACTH secretagogues corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) was examined in hypothalamic paraventricular nucleus (PVN) rats bearing hippocampal lesions. Either total hippocampectomy (HPX) or extirpation dorsal hippocampus (DHPX) precipitated a 4-fold increase CRF mRNA expression relative to sham-operated controls (SHAM), as determined by semiquantitative situ hybridization histochemistry. AVP localized individual parvocellular...
✓ Acute studies performed in five patients indicate that electrical stimulation of the brain could be a powerful tool for reduction or control intractable pain. While chronic spontaneous pain relieved by periaqueductal gray matter, accompanying side effects render it impossible to stimulate this site regularly. On other hand, medial thalamic sites, particularly nucleus parafascicularis, yielded good relief at parameters which did not cause many undesirable effects. The same also produced...