Anders D. Børglum
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Birth, Development, and Health
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- Genetic Mapping and Diversity in Plants and Animals
- Adolescent and Pediatric Healthcare
- Congenital heart defects research
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Bioinformatics and Genomic Networks
- Cognitive Abilities and Testing
- Genetic Syndromes and Imprinting
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Diet and metabolism studies
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
Lundbeck Foundation
2016-2025
Aarhus University
2016-2025
Genetic Analysis (Norway)
2024
University of Utah
2023
Virginia Commonwealth University
2019-2023
Huntsman (United States)
2023
Central Denmark Region
2019-2022
Copenhagen University Hospital
2016-2022
Sankt Hans Hospital
2022
University of Copenhagen
2022
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...
We identified the α-cardiac actin gene (ACTC) as a novel disease in pedigree suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all previously reported FHC loci possible family studied, with lod scores varying between –2.5 and –6.0. Further linkage of plausible candidate genes highly expressed adult human heart ACTC most likely gene, showing maximal score 3.6. Mutation analysis revealed an Ala295Ser mutation exon 5 close to 2 missense mutations recently...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a devastating inherited disorder characterized by episodic syncope and/or sudden cardiac arrest during exercise or acute emotion in individuals without structural abnormalities. Although rare, CPVT suspected to cause substantial part of deaths young individuals. Mutations RYR2, encoding the sarcoplasmic calcium channel, have been identified as causative approximately half all dominantly cases. Applying genome-wide linkage...
Persons with mental disorders are at a higher risk than the general population for subsequent development of certain medical conditions.
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. iPSYCH2012 is nested within entire population born between 1981 2005, including 1 472 762 persons. This paper introduces outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146),...