A5069370336- Genomics and Rare Diseases
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Personality Disorders and Psychopathology
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Transcranial Magnetic Stimulation Studies
- Electroconvulsive Therapy Studies
- Parkinson's Disease Mechanisms and Treatments
- Mental Health Treatment and Access
- Suicide and Self-Harm Studies
- Attention Deficit Hyperactivity Disorder
- Genomic variations and chromosomal abnormalities
- Health, psychology, and well-being
- Genomics and Phylogenetic Studies
- Bipolar Disorder and Treatment
- Genetic Associations and Epidemiology
- Child Nutrition and Feeding Issues
- Research in Social Sciences
- Restless Legs Syndrome Research
- Obsessive-Compulsive Spectrum Disorders
- Botulinum Toxin and Related Neurological Disorders
- Crime Patterns and Interventions
- School Health and Nursing Education
- Mental Health and Psychiatry
- RNA and protein synthesis mechanisms
Helsinki University Hospital
2010-2024
University of Helsinki
2002-2022
Hospital District of Helsinki and Uusimaa
2008-2015
Peijas Hospital
2010-2015
Kellokoski Hospital
2008-2011
University of Turku
2011
Hyvinkää Hospital
2011
Varsinais-Suomen Sairaanhoitopiiri
2011
Vanha Vaasa hospital
2011
University of Eastern Finland
2010
Upstream open reading frames (uORFs) are tissue-specific cis-regulators of protein translation. Isolated reports have shown that variants create or disrupt uORFs can cause disease. Here, in a systematic genome-wide study using 15,708 whole genome sequences, we show new upstream start codons, and disrupting stop sites existing uORFs, under strong negative selection. This selection signal is significantly stronger for arising genes intolerant to loss-of-function variants. Furthermore, creating...
The Symptom Check‐List‐90 (SCL‐90) is a widely used psychiatric questionnaire which has not yet been validated in Finland. We investigated the utility of translated version SCL‐90 Finnish population, and set community norms for it. internal consistency original subscales was checked found to be good. Discriminant function analysis, based on nine subscales, showed that power discriminate between patients Factor analysis items yielded very strong unrotated first factor, suggesting general...
AbstractThe aim of the study was to compare screening properties two General Health Questionnaire (GHQ) versions and Symptom Checklist (SCL-90), evaluate them as psychiatric instruments in Finland. We administered GHQ-36 SCL-90 outpatients (n = 207) a community sample 315). Receiver operating characteristic (ROC) analysis used estimate performance GHQ-12 extracted from GHQ-36. The scales were found be good similar. Suggested optimal cut-off points 3/4 for GHQ-12, 8/9 0.90/0.91 SCL-90. In...
PURPOSE: This study explored psychiatric inpatients' experiences of, and their suggestions for, improvement of seclusion/restraint, alternatives to use in Finland. METHODS: The data were collected by focused interviews (n= 30) analyzed with inductive content analysis. RESULTS: Patients' perspectives received insufficient attention during seclusion/restraint processes. Improvements (e.g., humane treatment) empathetic patient–staff interaction) as suggested the patients, on essential parts...
Multi-nucleotide variants (MNVs), defined as two or more nearby existing on the same haplotype in an individual, are a clinically and biologically important class of genetic variation. However, tools typically do not accurately classify MNVs, understanding their mutational origins remains limited. Here, we systematically survey MNVs 125,748 whole exomes 15,708 genomes from Genome Aggregation Database (gnomAD). We identify 1,792,248 across genome with constituent falling within 2 bp distance...
Since most of the world's schizophrenia patients are treated with conventional antipsychotics, authors evaluated various methods for establishing prevalence neuroleptic-induced movement disorders in these patients.DSM-IV criteria and established score thresholds on a disorder rating scale were used to identify cases representative Estonian patient sample 99 chronic institutionalized patients, 18-65 years old, neuroleptics (79.8%) or clozapine (20.2%).Neuroleptic-induced according DSM-IV...
Distortion of the sense reality, actualized in delusions and hallucinations, is key feature psychosis but underlying neuronal correlates remain largely unknown. We studied 11 highly functioning subjects with schizophrenia or schizoaffective disorder while they rated reality auditory verbal hallucinations (AVH) during functional magnetic resonance imaging (fMRI). The subjective AVH correlated strongly specifically hallucination-related activation strength inferior frontal gyri (IFG),...
Abstract Background As pyromania is a rare diagnosis with questionable validity, we aimed to describe forensic psychiatric population of arson recidivists. Methods The medical records as well the examination statements 90 recidivists referred for pretrial assessment in Helsinki University Hospital Department Forensic Psychiatry between 1973 and 1993 were reviewed. Results most important diagnostic categories personality disorders, psychosis mental retardation, often comorbid alcoholism. In...
Abstract Background Simpson-Angus Scale (SAS) is an established instrument for neuroleptic-induced parkinsonism (NIP), but its statistical properties have been studied insufficiently. Some shortcomings concerning content suggested as well. According to a recent report, the widely used SAS mean score cut-off value 0.3 of NIP detection may be too low. Our aim was evaluate against DSM-IV diagnostic criteria and objective motor assessment (actometry). Methods Ninety-nine chronic...
In a double-blind, controlled study, we examined the therapeutic effects of high-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) on schizophrenia symptoms. A total 22 chronic hospitalized patients were randomly assigned to 2 weeks (10 sessions) real or sham rTMS. rTMS was given with following parameters: 20 trains 5-second 10-Hz at 100 percent motor threshold, 30 seconds apart. Effects positive and negative symptoms, self-reported rough neuropsychological...
Accurate assessment of suicidality is major importance in both clinical and research settings. The Scale for Suicidal Ideation (SSI) a well-established clinician-rating scale but its suitability to adolescents has not been studied. aim this study was evaluate the reliability validity, test an appropriate cutoff threshold SSI depressed adolescent outpatient population controls. 218 psychiatric clinic patients suffering from depressive disorders 200 age- sex-matched school-attending controls...
Background: A polymorphism in the promoter region of monoamine oxidase gene ( MAOA ) has been shown to alter effect persistent drinking and childhood maltreatment on risk for violent antisocial behaviors. These findings indicate that could contribute inter‐individual differences stress resiliency. Methods: Recidivism severe crimes was assessed after 8 years nonincarcerated follow‐up a male sample 174 impulsive Finnish alcoholic offenders, majority whom exhibited (ASPD) or borderline...
Antonovsky's Sense of Coherence Scale (SOC) and Bond's Defense Style Questionnaire (DSQ) were compared in a sample 334 community controls 122 psychiatric outpatients. The major question was, whether the two coping inventories with different theoretical backgrounds-stress research vs. psycho-analysis-tap similar phenomena. affinity measures was evident: multiple regression analysis defenses explained 68% variance sense coherence. Not surprisingly, SOC scale-emerging out salutogenic...
This study examined the psychometric properties of Defense Style Questionnaire (DSQ-40) in adolescents. Internal consistency, factor structure, and discriminant concurrent validity DSQ-40 were studied 211 adolescent psychiatric outpatients aged 13 to 19 years 199 age-matched sex-matched controls. Principal components analysis yielded four internally consistent components: mature, neurotic, image-distorting, immature defense styles. The reported more immature, neurotic styles less mature...
Environmental factors appear to interact with a functional polymorphism (MAOA-LPR) in the promoter region of monoamine oxidase A gene (MAOA) determining some forms antisocial behavior. However, how MAOA-LPR modulates effects other such as alcohol consumption related behavior is not completely understood.
Despite the abundant literature on physical comorbidity, full range of concurrent somatic healthcare needs among individuals with schizophrenia has rarely been studied.This observational study aimed to assess distressing symptoms and for health interventions in outpatients schizophrenia, factors predicting those needs.A structured, comprehensive examination was carried out, including a visit nurse general practitioner 275 schizophrenia. The required were classified by type disease. Logistic...
The aim of the study was to evaluate psychopathy-like personality traits in a nationwide consecutive sample adolescent male homicide offenders and compare findings with those randomly sampled adult offender group. A further investigate associations between psychopathic offence characteristics homicides. Forensic psychiatric examination reports crime all 15 to19- year- old Finnish who had been subjected forensic convicted for during 1995–2004 were collected (n = 57). random 57 selected as...