Craig L. Hanis
A5003198381- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Diabetes Management and Education
- Pancreatic function and diabetes
- Genetic and phenotypic traits in livestock
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Diabetes and associated disorders
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Obstructive Sleep Apnea Research
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Risk Factors
- Diet, Metabolism, and Disease
- Health Policy Implementation Science
- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Heavy Metal Exposure and Toxicity
- Diabetes Management and Research
- Calpain Protease Function and Regulation
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
The University of Texas Health Science Center at Houston
2016-2025
University of Szeged
2024
Louisiana State University Health Sciences Center New Orleans
2024
The University of Texas at Austin
1987-2023
Medical Research Council
2023
University of Oxford
2015-2023
University of Houston
1991-2023
Diagnostics Research Group
2020
Arkana Laboratories
2020
Loyola University Chicago
2002-2019
We examined the contributions of genetic factors and family environment to human fatness in a sample 540 adult Danish adoptees who were selected from population 3580 divided into four weight classes: thin, median weight, overweight, obese. There was strong relation between class body-mass index their biologic parents — for mothers, P<0.0001; fathers, P<0.02. no adoptive parents. Cumulative distributions showed similar results; there adoptee class. Furthermore, not confined obesity class, but...
OBJECTIVE—To determine the effects of a culturally competent diabetes self-management intervention in Mexican Americans with type 2 diabetes. RESEARCH DESIGN AND METHODS—A prospective, randomized, repeated measures study was conducted on Texas-Mexico border Starr County. A total 256 randomly selected individuals between 35 and 70 years age, diagnosed after accompanied by family member or friend were included. The consisted 52 contact hours over 12 months provided bilingual American nurses,...
<h3>Importance</h3> Latino populations have one of the highest prevalences type 2 diabetes worldwide. <h3>Objectives</h3> To investigate association between rare protein-coding genetic variants and prevalence in a large population to explore potential molecular physiological mechanisms for observed relationships. <h3>Design, Setting, Participants</h3> Whole-exome sequencing was performed on DNA samples from 3756 Mexican US individuals (1794 with 1962 without diabetes) recruited 1993 2013....
Summary Background Faecal microbiota transplantation ( FMT ) has become routine in managing recurrent C. difficile infection CDI refractory to antibiotics. Aim To compare clinical response and improvements colonic diversity subjects with using different donor product. Methods Seventy‐two ≥3 bouts of were randomised a double‐blind study receive fresh, frozen or lyophilised product via colonoscopy from 50 g stool per treatment eight healthy donors. Recipients provided stools pre‐ 7, 14 30 days...
Abstract Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of gene inactivation complements knockout studies cells and organisms. Here we report three key findings regarding the assessment candidate drug targets using loss-of-function variants. First, even essential genes, which not tolerated, can be highly successful as inhibitory drugs. Second, most sufficiently rare genotype-based ascertainment homozygous or compound...
Upstream open reading frames (uORFs) are tissue-specific cis-regulators of protein translation. Isolated reports have shown that variants create or disrupt uORFs can cause disease. Here, in a systematic genome-wide study using 15,708 whole genome sequences, we show new upstream start codons, and disrupting stop sites existing uORFs, under strong negative selection. This selection signal is significantly stronger for arising genes intolerant to loss-of-function variants. Furthermore, creating...
OBJECTIVE— This study reports the psychometric properties of 24-item version Diabetes Knowledge Questionnaire (DKQ). RESEARCH DESIGN AND METHODS— The original 60-item DKQ was administered to 502 adult Mexican-Americans with type 2 diabetes who are part Starr County Education Study. sample composed 252 participants and 250 support partners. subjects were randomly assigned educational social intervention (n = 250) or wait-listed control group 252). A shortened derived from instrument after...
Abstract The ethnic and geographic distributions of several common chronic diseases show distinct patterns that are consistent with the distribution genes genetic admixture. For example, diabetes gallbladder disease occur most frequently among Amerindians, while those genetically admixed them (such as Mexican‐Americans) have intermediate rates, lowest rates found Whites Blacks. Because there will be heterogeneity from individual to in ancestral affinity within an population, a method is...
The purpose of this article was to characterize the origins United States Hispanic population and discuss implications these in context diabetes risk. Particular attention focused on genetic three major U.S. groups, i.e., Mexican Americans, Puerto Ricans, Cubans. Census figures provided basic demographic information. Genetic marker data for ancestral populations were taken from a review literature compendia. Rican Cuban extracted literature. markers determined ∼ 1000 randomly selected...
Currently, many Amerindian peoples, including European- admixed groups such as Mexicans, are experiencing a major epidemic of series diseases which includes tendency to become obese at an early adult age, onset diabetes mellitus, the formation cholesterol gallstones, and gallbladder cancer, especially in females. Other cancer sites, morbid consequences these primary disorders, also occur elevated rates. This has begun, or least increased dramatically since World War II, seems be due...
Journal Article DIABETES AMONG MEXICAN AMERICANS IN STARR COUNTY, TEXAS Get access CRAIG L. HANIS, HANIS 1Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University Texas Health Science Center at Houston, TX Reprint requests to Dr. Hanis, P.O. Box 20334, 77025. Search other works by this author on: Oxford Academic PubMed Google Scholar ROBERT E. FERRELL, FERRELL SARA A. BARTON, BARTON LYDIA AGUILAR, AGUILAR ANA GARZAIBARRA, GARZAIBARRA BRIAN R....
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection (OR 0.91, p = 2.3*10−11). This same also lower levels of hepatic fat on computed tomographic imaging odds physician-diagnosed fatty liver as well blood alanine transaminase (-0.025 SD, 3.7*10−43), alkaline phosphatase 1.2*10−37), total cholesterol (-0.030 1.9*10−36)...
Multi-nucleotide variants (MNVs), defined as two or more nearby existing on the same haplotype in an individual, are a clinically and biologically important class of genetic variation. However, tools typically do not accurately classify MNVs, understanding their mutational origins remains limited. Here, we systematically survey MNVs 125,748 whole exomes 15,708 genomes from Genome Aggregation Database (gnomAD). We identify 1,792,248 across genome with constituent falling within 2 bp distance...
To identify genetic loci for severe diabetic retinopathy, 286 Mexican-Americans with type 2 diabetes from Starr County, Texas, completed physical examinations including fundus photography retinopathy grading. Individuals moderate-to-severe non-proliferative and proliferative were defined as cases. Direct genotyping was performed using the Affymetrix GeneChip Human Mapping 100 K Set, SNPs passing quality control criteria used to impute markers available in HapMap Phase III Mexican population...
Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there strong clinical epidemiologic evidence supporting the importance of genetic factors in influencing obstructive apnea, its basis still largely unknown. Prior studies focused on traits defined using apnea-hypopnea index, which contains limited information potentially important genetically determined physiologic factors, such as propensity...
Abstract Human genetic variants predicted to cause loss-of-function of protein-coding genes (pLoF variants) provide natural in vivo models human gene inactivation and can be valuable indicators function the potential toxicity therapeutic inhibitors targeting these 1,2 . Gain-of-kinase-function LRRK2 are known significantly increase risk Parkinson’s disease 3,4 , suggesting that inhibition kinase activity is a promising strategy. While preclinical studies model organisms have raised some...