A5049741676- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Forensic and Genetic Research
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Pleistocene-Era Hominins and Archaeology
- Genetic diversity and population structure
- Cancer Genomics and Diagnostics
- Forensic Anthropology and Bioarchaeology Studies
- Ethics in Clinical Research
- AI in cancer detection
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Explainable Artificial Intelligence (XAI)
- Evolution and Genetic Dynamics
- Single-cell and spatial transcriptomics
- Protein Structure and Dynamics
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- Chromosomal and Genetic Variations
- Archaeology and ancient environmental studies
University of California, Los Angeles
2013-2024
QB3
2022
AndroScience (United States)
2022
UCLA Health
2016-2020
Harvard University
2012-2016
Broad Institute
2012-2016
University of California, San Francisco
2013-2015
Tel Aviv University
2009-2015
Microsoft (United States)
2015
University of Southern California
2010-2013
In a pair of seminal papers, Sewall Wright and Gustave Malécot introduced F ST as measure structure in natural populations. the decades that followed, number papers provided differing definitions, estimation methods, interpretations beyond Wright's. While this diversity methods has enabled many studies genetics, it also confusion regarding how to estimate from available data. Considering confusion, wide variation published estimates for pairs HapMap populations is cause concern. These...
Comparisons of DNA sequences between Neandertals and present-day humans have shown that share more genetic variants with non-Africans than Africans. This could be due to interbreeding modern when the two groups met subsequent emergence outside Africa. However, it also population structure antedates origin Neandertal ancestors in We measure extent linkage disequilibrium (LD) genomes Europeans find last gene flow from (or their relatives) into likely occurred 37,000–86,000 years before present...
Selection, recombination, and hybrid evolution Hybridization is an important force in evolution. The effects of hybridization across the whole genome are not understood. Using a fine-scale genetic map, Schumer et al. examined local ancestry replicate natural populations swordtail fish. Each parental species contributes different proportions material to genomes their descendants. Genes from “minor” (less well-represented) parent occur regions that subject higher recombination rates where...
Abstract Motivation: It is becoming increasingly evident that the analysis of genotype data from recently admixed populations providing important insights into medical genetics and population history. Such analyses have been used to identify novel disease loci, understand recombination rate variation detect recent selection events. The utility such studies crucially depends on accurate unbiased estimation ancestry at every genomic locus in populations. Although various methods proposed shown...
The observation of genetic correlations between disparate human traits has been interpreted as evidence widespread pleiotropy. Here, we introduce cross-trait assortative mating (xAM) an alternative explanation. We observe that xAM affects many phenotypes and phenotypic cross-mate correlation estimates are strongly associated with ( R 2 = 74%). demonstrate existing plausibly accounts for substantial fractions previously reported some pairs psychiatric disorders congruent alone. Finally,...
Significance We report a method for dating ancient human samples that uses the recombination clock. To infer age of genomes, we take advantage shared history Neanderthal gene flow into non-Africans occurred around 50,000 y ago and measure amount “missing evolution” in terms breakpoints genome compared with present-day samples. show this provides estimates are highly correlated to radiocarbon dates, thus documenting promise approach. By studying linear relationship between dates admixture...
Abstract A characterization of the genetic variation recently admixed populations may reveal historical population events, and is useful for detection single nucleotide polymorphisms (SNPs) associated with diseases through association studies admixture mapping. Inference locus-specific ancestry key to our understanding such populations. While a number methods inference are accurate when ancestral quite distant (e.g. African–Americans), current incur large error rate inferring in where...
Abstract High costs and technical limitations of cell sorting single-cell techniques currently restrict the collection large-scale, cell-type-specific DNA methylation data. This, in turn, impedes our ability to tackle key biological questions that pertain variation within a population, such as identification disease-associated genes at resolution. Here, we show mathematically empirically levels an individual can be learned from its tissue-level bulk data, conceptually emulating case where...
Multiple West African populations inherited genes from a population that diverged before modern humans and Neanderthals split.
Genetic effects on gene expression and splicing can be modulated by cellular environmental factors; yet interactions between genotypes, cell type, treatment have not been comprehensively studied together. We used an induced pluripotent stem system to study multiple types derived from the same individuals exposed them a large panel of treatments. Cellular responses involved different genes pathways for were highly variable across contexts. For thousands genes, we identified allelic contexts...