A5074116143- Genetic Associations and Epidemiology
- Dermatology and Skin Diseases
- Forensic and Genetic Research
- Genetic diversity and population structure
- Allergic Rhinitis and Sensitization
- Genetic Mapping and Diversity in Plants and Animals
- Complementary and Alternative Medicine Studies
- Genetic and phenotypic traits in livestock
- Bone health and osteoporosis research
- Acupuncture Treatment Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Bone Metabolism and Diseases
- Attention Deficit Hyperactivity Disorder
- Epigenetics and DNA Methylation
- Bone health and treatments
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Forensic Anthropology and Bioarchaeology Studies
- Contact Dermatitis and Allergies
- Race, Genetics, and Society
- Chromosomal and Genetic Variations
- Advanced Causal Inference Techniques
- Pleistocene-Era Hominins and Archaeology
- Skin Protection and Aging
- Lipoproteins and Cardiovascular Health
Institut de Biologia Evolutiva
2022-2025
Universitat de Barcelona
2005-2025
Lundbeck Foundation
2022-2024
Mental Health Services
2021-2024
Copenhagen University Hospital
2022-2024
Sankt Hans Hospital
2023
University of Copenhagen
2018-2022
Aarhus University
2016-2022
Capital Region of Denmark
2022
University of Toronto
2019
The observation of genetic correlations between disparate human traits has been interpreted as evidence widespread pleiotropy. Here, we introduce cross-trait assortative mating (xAM) an alternative explanation. We observe that xAM affects many phenotypes and phenotypic cross-mate correlation estimates are strongly associated with ( R 2 = 74%). demonstrate existing plausibly accounts for substantial fractions previously reported some pairs psychiatric disorders congruent alone. Finally,...
We analyzed genome sequences from 6 baboon species and found evidence of ancient recent hybridization among divergent species.
Itch is a major symptom of allergic skin disease. Acupuncture has been shown to exhibit significant effect on histamine-induced itch in healthy volunteers. We investigated the acupuncture type I hypersensitivity and reaction double-blind, randomized, placebo-controlled, crossover trial.An allergen stimulus (house dust mite or grass pollen prick) was applied 30 patients with atopic eczema before (direct effect) after (preventive two experimental approaches control observation: at points Quchi...
Abstract Background Itch is the major symptom of atopic dermatitis ( AD ). Acupuncture has been shown to exhibit a significant effect on experimental itch in . Our study evaluated acupuncture and antihistamine therapy (cetirizine) type I hypersensitivity skin reaction using patient examiner‐blinded, randomized, placebo‐controlled, crossover trial. Methods Allergen‐induced was 20 patients with after several interventions separate sessions: preventive (preceding) abortive (concurrent) verum VA...
A population in a natural crossroad within Europe reveals multiple ancient contributions and substantial structure.
Abstract Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood psychiatric disorder, with major genetic component. Here we present GWAS meta-analysis of ADHD comprising 38,691 individuals and 186,843 controls. We identified 27 genome-wide significant loci, which more than twice the number previously reported. Fine-mapping risk loci highlighted 76 potential genes enriched in expressed brain, particularly frontal cortex, early brain development. Overall, was associated...
The crucial symptom of atopic eczema is itch. Acupuncture has been shown to exhibit a significant effect on experimental itch; however, studies focusing clinical itch in and corresponding mechanisms are lacking. study design was unicenter, single-blinded (observer), prospective, randomized pilot trial with an additional part. In 10 patients eczema, we investigated the acupuncture treatment (n = 5) compared no intensity vitro basophil CD63 expression upon allergen stimulation (house dust mite...
Denmark has played a substantial role in the history of Northern Europe. Through nationwide scientific outreach initiative, we collected genetic and anthropometrical data from ∼800 high school students used them to elucidate makeup Danish population, as well assess polygenic predictions phenotypic traits adolescents. We observed remarkable homogeneity across different geographic regions, although could still detect weak signals structure reflecting country. presented genomic affinity with...
Genome-wide association studies (GWASs) have revolutionized human genetics, allowing researchers to identify thousands of disease-related genes and possible drug targets. However, case-control status does not account for the fact that all controls may lived through their period risk disorder interest. This can be quantified by examining age-of-onset distribution age or onset cases. The also depend on information such as sex birth year. In addition, family history is routinely included in...
Significance The ability to extract multigenerational family relationships from large-scale population cohorts provides a powerful means understand the heritability of wide range diseases and their genetic each other. By showing how broad diagnostic categories changes over time said are related on level, our analysis Danish genealogy linked national patient registers illustrates vast potential this resource in current biomedical research.
Itch is the major symptom of many allergic diseases; yet it still difficult to measure objectively. The aim this study was use an evaluated itch stimulus model in lesional (LS) and nonlesional (NLS) atopic eczema (AE) skin characterize cerebral responses using functional magnetic resonance imaging (fMRI).Thermal modulation performed on a histamine randomized order LS or NLS rapid alternating from 32 degrees C (warm) 25 (cold). Subjective ratings were recorded. Additionally, fMRI measurements...
Abstract Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this still poorly understood. We leverage nation-wide health records near-complete genealogies Denmark Sweden (n = 17 million) reveal the genetic environmental contributions underlying observed between six mental 15 Genetic factors contributed about 50% schizophrenia, affective disorders, autism spectrum disorder whereas...
Abstract The variation of 18 Alu polymorphisms and 3 linked STRs was determined in 1,831 individuals from 15 Mediterranean populations to analyze the relationships between human groups this geographical region provide a complementary perspective information studies based on uniparental markers. Patterns population diversity revealed by two kinds markers examined were different one another, likely relation their mutation rates. Therefore, while biallelic underlies general heterogeneity...
The observation of genetic correlations between disparate traits has been interpreted as evidence widespread pleiotropy, altered theories human architecture, and spurred considerable research activity across the natural social sciences. Here, we introduce cross-trait assortative mating (xAM) an alternative explanation for observed correlations. We observe that xAM is common a broad array phenotypes phenotypic cross-mate correlation estimates are strongly associated with ( R 2 = 76%). Then,...
Abstract Major depression (MD) is a common mental disorder and leading cause of disability worldwide. We conducted GWAS meta-analysis more than 1.3 million individuals, including 371,184 with MD, identifying 243 risk loci. Sixty-four loci are novel, glutamate GABA receptors that targets for antidepressant drugs. Several biological pathways components were enriched genetic MD risk, implicating neuronal development function. Intersection functional genomics data prioritized likely causal genes...