A5035707382- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Pacific and Southeast Asian Studies
- Global Maritime and Colonial Histories
- Pleistocene-Era Hominins and Archaeology
- Oral Health Pathology and Treatment
- Race, Genetics, and Society
- Genetic Associations and Epidemiology
- High Altitude and Hypoxia
- Identification and Quantification in Food
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Bat Biology and Ecology Studies
- Prenatal Screening and Diagnostics
- Travel-related health issues
- Toxoplasma gondii Research Studies
- Nuts composition and effects
- Otolaryngology and Infectious Diseases
- African Studies and Ethnography
- Migration, Identity, and Health
- Anthropological Studies and Insights
- T-cell and Retrovirus Studies
- Dental Health and Care Utilization
Université de Toulouse
2011-2024
Centre National de la Recherche Scientifique
2011-2024
Université Toulouse III - Paul Sabatier
2010-2024
Institut de Recherche pour le Développement
2019-2024
Centre de Recherche sur la Biodiversité et l'Environnement
2024
Laboratoire Evolution et Diversite Biologique
2019-2024
AMIS - Laboratoire d'anthropologie moléculaire et imagerie de synthèse
2009-2019
Leiden University
2015
Max Planck Institute for Psycholinguistics
2011-2015
Laboratoire de Microbiologie et Génétique Moléculaires
2011
The Neolithic is a key period in the history of European settlement. Although archaeological and present-day genetic data suggest several hypotheses regarding human migration patterns at this period, validation these with use ancient has been limited. In context, we studied DNA extracted from 53 individuals buried necropolis used by French local community 5,000 y ago. relatively good preservation samples allowed us to obtain autosomal, Y-chromosomal, and/or mtDNA for 29 studied. From...
Significance The origins of the Malagasy raise questions about ancient connections between continents; moreover, because ancestors are fundamental to society, is also a heated topic around country, with numerous proposed hypotheses. This study provides comprehensive view genomic diversity (including maternal lineages, paternal and genome-wide data) based on sampling 257 villages across Madagascar. observed spatial patterns lead scenario recent sex-biased admixture Bantu Austronesian island....
Linguistic, cultural and genetic characteristics of the Malagasy suggest that both Africans Island Southeast Asians were involved in colonization Madagascar. Populations from Indonesian archipelago played an especially important role because linguistic evidence suggests language branches Barito family southern Borneo, Indonesia, with closest spoken today by Ma'anyan. To test for a link between these linguistically related populations, we studied Ma'anyan other ethnic groups (including sea...
Malagasy genetic diversity results from an exceptional protoglobalization process that took place over a thousand years ago across the Indian Ocean. Previous efforts to locate Asian origin of highlighted Borneo broadly as potential source, but so far no firm source populations were identified. Here, we have generated genome-wide data two Southeast populations, Banjar and Ngaju, together with published Ocean region. We find strong support for ancestry among Banjar. This group emerged...
The impact of the Neolithic dispersal on western European populations is subject to continuing debate. To trace and date genetic lineages potentially brought during this transition so understand origin gene pool current populations, we studied DNA extracted from human remains excavated in a Spanish funeral cave dating beginning fifth millennium B.C. Thanks “multimarkers” approach based analysis mitochondrial nuclear (autosomes Y-chromosome), obtained information early practices...
Abstract The Austronesian expansion, one of the last major human migrations, influenced regions as distant tropical Asia, Remote Oceania and Madagascar, off east coast Africa. identity Asian groups that settled Madagascar is particularly mysterious. While language connects to Ma’anyan southern Borneo, haploid genetic data are more ambiguous. Here, we screened genome-wide diversity in 211 individuals from surrounding Borneo. Surprisingly, characterized by a distinct, high frequency genomic...
The Bajo, the world's largest remaining sea nomad group, are scattered across hundreds of recently settled communities in Island Southeast Asia, along coasts Indonesia, Malaysia and Philippines. With a significant role historical trading, Bajo lived until as nomads, spending their entire lives on houseboats while moving long distances to fish trade. Along routes they traveled, intermarried with local land-based groups, leading 'maritime creolization', process whereby retained culture, but...
The Austronesian dispersal across the Indonesian Ocean to Madagascar and Comoros has been well documented, but in an unexplained anomaly, few no traces have found of expansion East Africa or Arabian Peninsula. To revisit this peculiarity, we surveyed Western Indian rim populations identify potential genetic ancestry. We generated full mitochondrial DNA genomes genome-wide genotyping data for these individuals compared them with Banjar, source population westward dispersal. find strong...
Abstract Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia environment-specific pathogen exposure, respectively. In this study, we explored the top genomics regions candidate driver SNPs for selection in these two populations using newly sequenced whole-genomes 54 highlanders 74 lowlanders. We identified under - one highlanders, associated with red blood cell traits another lowlanders, which is white count – both potentially influencing...
The Indian Ocean has long been a hub of interacting human populations. Following land- and sea-based routes, trade drove cultural contacts between far-distant ethnic groups in Asia, India, the Middle East Africa, creating one world's first proto-globalized environments. However, extent to which population mixing was mediated by is poorly understood. Reconstructing admixture times from genomic data 3,006 individuals 187 regional populations reveals close association bouts migration volumes...
A population in a natural crossroad within Europe reveals multiple ancient contributions and substantial structure.
Modern humans have admixed with multiple archaic hominins. Papuans, in particular, owe up to 5% of their genome Denisovans, a sister group Neanderthals whose remains only been identified Siberia and Tibet. Unfortunately, the biological evolutionary significance these introgression events remain poorly understood. Here we investigate function both Denisovan Neanderthal alleles characterised within set 56 genomes from Papuan individuals. By comparing distribution non-archaic variants assess...
Abstract New Guineans represent one of the oldest locally continuous populations outside Africa, harboring among greatest linguistic and genetic diversity on planet. Archeological evidence suggest that their ancestors reached Sahul (present day Guinea Australia) by at least 55,000 years ago (kya). However, little is known about this early settlement phase or subsequent dispersal population structuring over period time. Here we report 379 complete Papuan mitochondrial genomes from across...
Retracing the genetic histories of descendant populations Slave Trade (16th-19th centuries) is particularly challenging due to diversity African ethnic groups involved and different hybridisation processes with Europeans Amerindians, which have blurred their original inheritances. The Noir Marron in French Guiana are direct descendants maroons who escaped from Dutch plantations current day Surinam. They represent an group a highly blended culture. Uniparental markers (mtDNA NRY) coupled...
Abstract The Arabian Peninsula (AP) was an important crossroad between Africa, Asia, and Europe, being the cradle of structure defining these main human population groups, a continuing path for their admixture. screening 741,000 variants in 420 Arabians 80 Iranians allowed us to quantify dominant sub-Saharan African admixture west peninsula, whereas South Asian Levantine/European influence stronger east, leading rift western eastern sides Peninsula. Dating events indicated that Indian Ocean...
Madagascar is located at the crossroads of Asian and African worlds therefore particular interest for studies on human population migration. Within large diversity Great Island, we focused our study a ethnic group, Antemoro. Their culture presents an important Arab-Islamic influence, but question Arab biological inheritance remains unresolved. We analyzed paternal (n=129) maternal (n=135) lineages this group. Although majority Antemoro genetic ancestry comes from sub-Saharan Southeast gene...
The settlement of Sahul, the lost continent Oceania, remains one most ancient and debated human migrations. Modern New Guineans inherited a unique genetic diversity tracing back 50,000 years, yet there is currently no model reconstructing their past population dynamics. We generated 58 new whole-genome sequences from Papua Guinea, filling geographical gaps in previous sampling, specifically to address alternative scenarios initial migration Sahul Guinea. Here, we present first genomic models...
Island Southeast Asia (ISEA) and Oceania host one of the world's richest assemblages human phenotypic, linguistic, cultural diversity. Despite this, region's male genetic lineages are globally among last to remain unresolved. We compiled ∼9.7 Mb Y chromosome (chrY) sequence from a diverse sample over 380 men this region, including 152 first reported here. The granularity data set allows us fully resolve date regional chrY phylogeny. This new high-resolution tree confirms two main population...
Neandertals and Denisovans, having inhabited distinct regions in Eurasia possibly Oceania for over 200,000 y, experienced ample time to adapt diverse environmental challenges these presented. Among present-day human populations, Papua New Guineans (PNG) stand out as one of the few carrying substantial amounts both Neandertal Denisovan DNA, a result past admixture events with archaic groups. This study investigates distribution introgressed DNA within two PNG residing highlands Mt Wilhelm...
Abstract Background Noncoding RNA (ncRNA) has been recognized as an important regulator of gene expression networks in Bacteria and Eucaryota. Little is known about ncRNA thermococcal archaea except for the eukaryotic-like C/D H/ACA modification guide RNAs. Results Using a combination silico experimental approaches, we identified characterized novel P . abyssi ncRNAs transcribed from 12 intergenic regions, ten which are conserved throughout Thermococcales. Several them accumulate...