A5053109390- Forensic and Genetic Research
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Race, Genetics, and Society
- Genomics and Phylogenetic Studies
- Pacific and Southeast Asian Studies
- Molecular Biology Techniques and Applications
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Yersinia bacterium, plague, ectoparasites research
- Genetic Associations and Epidemiology
- Archaeology and ancient environmental studies
- Metabolism and Genetic Disorders
- Language and cultural evolution
- Chromosomal and Genetic Variations
- Pleistocene-Era Hominins and Archaeology
- T-cell and B-cell Immunology
- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Reproductive System and Pregnancy
- Genetic and phenotypic traits in livestock
Max Planck Institute for Evolutionary Anthropology
2016-2025
Laboratoire de Biométrie et Biologie Evolutive
2021-2025
Université Claude Bernard Lyon 1
2021-2025
Centre National de la Recherche Scientifique
2021-2025
Max Planck Institute for Evolutionary Biology
2024
The Quebec Population Health Research Network
2023
Leipzig University
2004-2022
Children's Hospital of Philadelphia
2022
LIDSEN Publishing Inc. (United States)
2022
Max Planck Society
2009-2020
Using DNA extracted from a finger bone found in Denisova Cave southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is group that shares common origin with Neanderthals. population was not involved putative gene flow Neanderthals into Eurasians; however, data suggest it contributed 4–6% its genetic material genomes present-day Melanesians. We designate this 'Denisovans' and may been widespread Asia during Late Pleistocene epoch. A...
The proposal that all mitochondrial DNA (mtDNA) types in contemporary humans stem from a common ancestor present an African population some 200,000 years ago has attracted much attention. To study this further, two hypervariable segments of mtDNA were sequenced 189 people diverse geographic origin, including 121 native Africans. Geographic specificity was observed identical are shared within but not between populations. A tree relating these sequences to one another and chimpanzee sequence...
Journal Article Mitochondrial DNA and two perspectives on evolutionary genetics Get access ALLAN C. WILSON, WILSON 1Department of Biochemistry, University California, Berkeley, California 94720, U.S.A Search for other works by this author on: Oxford Academic Google Scholar REBECCA L. CANN, CANN U.S.A2Howard Hughes Medical Institute, U426, San Francisco, 94143, STEVEN M. CARR, CARR U.S.A3Wildlife Genetics Laboraiory, Department Wildlge Fisheries Sciences, Texas A & M University, College...
The frequencies of low-activity alleles glucose-6-phosphate dehydrogenase in humans are highly correlated with the prevalence malaria. These “deficiency” thought to provide reduced risk from infection by Plasmodium parasite and maintained at high frequency despite hemopathologies that they cause. Haplotype analysis “A−” ”Med“ mutations this locus indicates have evolved independently increased a rate is too rapid be explained random genetic drift. Statistical modeling A− allele arose within...
Genome-wide scanning for signals of recent positive selection is essential a comprehensive and systematic understanding human adaptation. Here, we present genomic survey local selective sweeps, especially aimed at those nearly or recently completed. A novel approach was developed such signals, based on contrasting the extended haplotype homozygosity (EHH) profiles between populations. We applied this method to genome single nucleotide polymorphism (SNP) data both International HapMap Project...
The human salivary microbiome may play a role in diseases of the oral cavity and interact with microbiomes from other parts body (in particular, intestinal tract), but little is known about normal variation microbiome. We analyzed 14,115 partial (∼500 bp) 16S ribosomal RNA (rRNA) sequences saliva samples 120 healthy individuals (10 each 12 worldwide locations). These could be assigned to 101 bacterial genera, which 39 were not previously reported cavity; phylogenetic analysis suggests that...
A specific segment of mitochondrial DNA from 18 people was examined by two methods direct sequencing. This includes a small noncoding region (V) shown before restriction analysis to exhibit length polymorphism. All 11 the human mtDNAs previously reported have deletion in this proved lack one adjacent copies 9-base-pair sequence normally present mtDNAs. Phylogenetic suggests that occurred only once during evolution modern types mtDNA and it will be valuable anthropological marker for peoples...
Human genetic history in East Asia is poorly understood. To clarify population relationships, we obtained genome-wide data from 26 ancient individuals northern and southern spanning 9500 to 300 years ago. Genetic differentiation this region was higher the past than present, which reflects a major episode of admixture involving Asian ancestry spreading across after Neolithic, thereby transforming China. Mainland Taiwan Strait island samples Neolithic show clear connections with modern...
Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships poorly understood. Here, we report data from 23 analysed at over half a million single-nucleotide polymorphisms, using genome-wide array designed for studying human history. The southern Khoisan fall into two groups, loosely corresponding northwestern southeastern Kalahari, which show separated within...
Heteroplasmy, the existence of multiple mtDNA types within an individual, has been previously detected by using mostly indirect methods and focusing largely on just hypervariable segments control region. Next-generation sequencing technologies should enable studies heteroplasmy across entire genome at much higher resolution, because many independent reads are generated for each position. However, error rate associated with these must be taken into consideration to avoid false detection...
Significance The hunter–gatherer and pastoralist populations of southern Africa are among the culturally, linguistically, genetically most diverse human populations. However, little is known about their history. We show that all these have some ancestry closely related to Europeans Middle Easterners use this reconstruct history population movements between Eurasia, eastern Africa, Africa.
Significance Heteroplasmy is the existence of different mtDNA sequences within an individual due to somatic or inherited mutations, and it has been implicated in many mtDNA-related diseases, other cancer, aging. However, little known about how heteroplasmy varies across tissues from same individual; here, we analyzed variation entire genome 12 obtained at autopsy each 152 individuals. Our results suggest that addition neutral processes negative selection, positive selection important...
Alu insertion polymorphisms (polymorphisms consisting of the presence/absence an element at a particular chromosomal location) offer several advantages over other nuclear DNA for human evolution studies. First, they are typed by rapid, simple, PCR-based assays; second, stable polymorphisms—newly inserted elements rarely undergo deletion; third, presence represents identity descent—the probability that different would independently insert into exact same location is negligible; and fourth,...