A5041239322- Genomics and Phylogenetic Studies
- Forensic and Genetic Research
- Syphilis Diagnosis and Treatment
- Child Development and Digital Technology
- Reproductive tract infections research
- Genomic variations and chromosomal abnormalities
- Forensic Anthropology and Bioarchaeology Studies
- Salivary Gland Disorders and Functions
- Genomics and Rare Diseases
- Gut microbiota and health
- Microbial infections and disease research
- Pacific and Southeast Asian Studies
- Genetics and Neurodevelopmental Disorders
- Oral microbiology and periodontitis research
- Genetic diversity and population structure
- Cancer Genomics and Diagnostics
- Malaria Research and Control
- Metabolomics and Mass Spectrometry Studies
- Virology and Viral Diseases
- Sex work and related issues
- Cancer-related molecular mechanisms research
- Archaeology and ancient environmental studies
- Pleistocene-Era Hominins and Archaeology
- Genetics, Bioinformatics, and Biomedical Research
- interferon and immune responses
University of North Carolina at Chapel Hill
2024
Oklahoma Medical Research Foundation
2021-2023
Monash University Malaysia
2015-2022
Monash University
2019
The human occupation history of Southeast Asia (SEA) remains heavily debated. Current evidence suggests that SEA was occupied by Hòabìnhian hunter-gatherers until ~4000 years ago, when farming economies developed and expanded, restricting foraging groups to remote habitats. Some argue agricultural development indigenous; others favor the "two-layer" hypothesis posits a southward expansion farmers giving rise present-day Asian genetic diversity. By sequencing 26 ancient genomes (25 from SEA,...
Abstract Sjögren’s disease is a complex autoimmune with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel significant (GWS) regions in cases of European ancestry: CD247 , NAB1 PTTG1-MIR146A PRDM1-ATG5 TNFAIP3 XKR6 MAPT- CRHR1 RPTOR-CHMP6-BAIAP6 TYK2 SYNGR1 . Polygenic risk scores yield predictability (AUROC = 0.71) and relative 12.08. Interrogation bioinformatics databases refine the associations, define local regulatory networks GWS SNPs...
Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history these remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups Negrito, Senoi, Proto-Malay. Structural analyses indicated that although all OA are genetically closest to East Asian (EA) populations, they substantially distinct. identified affinity between...
Human presence in Southeast Asia dates back to at least 40,000 years ago, when the current islands formed a continental shelf called Sundaland. In Philippine Islands, Peninsular Malaysia, and Andaman there exist indigenous groups collectively Negritos whose ancestry can be traced "First Sundaland People." To understand relationship between these Negrito their demographic histories, we generated genome-wide single nucleotide polymorphism data compared them with existing from other...
The increase in syphilis rates worldwide necessitates development of a vaccine with global efficacy. We aimed to explore Treponema pallidum subspecies (TPA) molecular epidemiology essential for research by analysing clinical data and specimens from early patients using whole-genome sequencing (WGS) publicly available WGS data.
Background Venereal syphilis, caused by the spirochete Treponema pallidum subsp. ( TPA ), is surging worldwide, underscoring need for a vaccine with global efficacy. Vaccine development requires an understanding of syphilis epidemiology and clinical presentation as well genomic characterization strains circulating within at-risk populations. The aim this study was to describe clinical, demographic, molecular features early cases in Cali, Colombia. Methods findings We conducted...
ABSTRACT Knowledge of Treponema pallidum subspecies ( TPA ) outer membrane protein (OMP) sequence variability is essential for understanding spirochete proliferation within endemic populations as well design a globally effective syphilis vaccine. Our group has identified extracellular loops (ECLs) BamA (TP0326) and members the FadL family (TP0548, TP0856, TP0858, TP0859, TP0865) potential components multivalent vaccine cocktail. As part consortium to explore strain diversity, we mapped...
Yaws affects children in tropical regions, while syphilis primarily sexually active adults worldwide. Despite various campaigns towards the eradication of yaws and elimination syphilis, these two diseases are still present Ghana. The aetiological agents both diseases, Treponema pallidum subspecies, genetically similar. This study aimed to assess prevalence treponematoses occurrence pathogens causing similar skin lesions Ashanti region A point-of-care test was used determine seroprevalence...
Abstract Background The demographic history of South and Southeast Asia (S&SEA) is complex contentious, with multiple waves human migration. Some the earliest footfalls were ancestors modern Austroasiatic (AA) language speakers. Understanding AA family, comprising over 150 languages their speakers distributed across broad geographical region in isolated small populations various sizes, can help shed light on peopling S&SEA. Here we investigated genetic relatedness two groups,...
Syphilis is a sexually transmitted infection caused by the highly invasive and immunoevasive spirochetal pathogen Treponema pallidum subsp. ( TPA ). Untreated syphilis can lead to of multiple organ systems, including central nervous system. The alarming increase in cases globally underscores importance developing novel strategies understand complexities pathogenesis. In this study, we took advantage recent advances vitro cultivation genetic manipulation spirochetes engineer strain that...
ABSTRACT Syphilis is a sexually transmitted infection caused by the highly invasive and immunoevasive spirochetal pathogen Treponema pallidum subsp. ( TPA ). Untreated syphilis can lead to of multiple organ systems, including central nervous system. The alarming increase in cases globally underscores importance developing novel strategies understand complexities pathogenesis. In this study, we took advantage recent advances vitro cultivation genetic manipulation spirochetes engineer strain...
<ns4:p><ns4:bold>Background:</ns4:bold> The indigenous people of Peninsular Malaysia, also known as Orang Asli, have gradually been urbanized. A shift towards non-communicable diseases commonly associated with sedentary lifestyles reported in many tribes. This study engaged a semi-urbanized Temiar tribe from Kampong Pos Piah, Perak, who are experiencing an epidemiological transition.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Weight, height, waist circumference, blood pressure, HbA1C and...
<ns4:p><ns4:bold>Background:</ns4:bold> The indigenous people of Peninsular Malaysia, also known as Orang Asli, have gradually been urbanized. A shift towards non-communicable diseases commonly associated with sedentary lifestyles reported in many tribes. This study engaged a semi-urbanized Temiar tribe from Kampong Pos Piah, Perak, who are experiencing an epidemiological transition.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Weight, height, waist circumference, blood pressure, HbA1C and...
Abstract Background Recent advances in genomic technologies have facilitated genome-wide investigation of human genetic variations. However, most efforts focused on the major populations, yet trio genomes indigenous populations from Southeast Asia been under-investigated. Results We analyzed whole-genome deep sequencing data (~ 30×) five native trios Peninsular Malaysia and North Borneo, characterized variants, including single nucleotide variants (SNVs), small insertions deletions (indels)...
Abstract Background Publicly available genome data provides valuable information on the genetic variation patterns across different modern human populations. Neuropeptide genes are crucial to nervous, immune, endocrine system, and physiological homeostasis as they play an essential role in communicating neuronal functions. It remains unclear how evolutionary forces, such natural selection random drift, have affected neuropeptide among To date, there over 100 known neuropeptides from 1000...
is geographically widespread but neglected and may become more prevalent as