A5010229793- Archaeology and ancient environmental studies
- Isotope Analysis in Ecology
- Pacific and Southeast Asian Studies
- Forensic Anthropology and Bioarchaeology Studies
- Pleistocene-Era Hominins and Archaeology
- Geology and Paleoclimatology Research
- Forensic and Genetic Research
- Paleopathology and ancient diseases
- Indigenous Studies and Ecology
- Linguistics and Cultural Studies
- Yersinia bacterium, plague, ectoparasites research
- Methane Hydrates and Related Phenomena
- Nuclear Physics and Applications
- Coral and Marine Ecosystems Studies
- Geological and Geophysical Studies
- Marine and coastal ecosystems
- Hormonal Regulation and Hypertension
- Air Quality and Health Impacts
- Genetic diversity and population structure
- Musculoskeletal pain and rehabilitation
- Receptor Mechanisms and Signaling
- Toxic Organic Pollutants Impact
- Atmospheric chemistry and aerosols
- Eurasian Exchange Networks
- Evolution and Paleontology Studies
The University of Tokyo
2015-2024
University of Tokyo Hospital
2016-2024
Tokyo National Museum
2021
Bunkyo University
2020
Meiji University
2019
Nippon Medical School
2017
Fukushima Medical University
2005-2015
Kyoto University
2015
Yamaguchi University
2013
Osaka City University
2011
The human occupation history of Southeast Asia (SEA) remains heavily debated. Current evidence suggests that SEA was occupied by Hòabìnhian hunter-gatherers until ~4000 years ago, when farming economies developed and expanded, restricting foraging groups to remote habitats. Some argue agricultural development indigenous; others favor the "two-layer" hypothesis posits a southward expansion farmers giving rise present-day Asian genetic diversity. By sequencing 26 ancient genomes (25 from SEA,...
Abstract The origin and early dispersal of speakers Transeurasian languages—that is, Japanese, Korean, Tungusic, Mongolic Turkic—is among the most disputed issues Eurasian population history 1–3 . A key problem is relationship between linguistic dispersals, agricultural expansions movements 4,5 Here we address this question by ‘triangulating’ genetics, archaeology linguistics in a unified perspective. We report wide-ranging datasets from these disciplines, including comprehensive...
Nitrogen isotope analysis of bone collagen has been used to reconstruct the breastfeeding practices archaeological human populations. However, weaning ages have estimated subjectively because a lack both information on subadult turnover rates and appropriate analytical models.Temporal changes in were from data tissue-level metabolism reported previous studies. A model for reconstructing precise was then developed using framework approximate Bayesian computation incorporating rates. The is...
Nitrogen stable isotopes analysis of individual bone collagen amino acids was applied to archeological samples as a new tool for assessing the composition ancient human diets and calibrating radiocarbon dates. We used this technique investigate faunal from Kitakogane shell midden in Hokkaido, Japan (5,300-6,000 cal BP). Using compound-specific nitrogen isotope acids, we aimed estimate i) quantitative contribution marine terrestrial protein diet, ii) mean trophic level (TL) which dietary...
The Jomon period of the Japanese Archipelago, characterized by cord-marked 'jomon' potteries, has yielded abundant human skeletal remains. However, genetic origins people and their relationships with modern populations have not been clarified. We determined a total 115 million base pair nuclear genome sequences from two individuals (male female each) Sanganji Shell Mound (dated 3000 years before present) Jomon-characteristic mitochondrial DNA haplogroup N9b, compared these those worldwide...
Abstract Anatomically modern humans reached East Asia more than 40,000 years ago. However, key questions still remain unanswered with regard to the route(s) and number of wave(s) in dispersal into Eurasia. Ancient genomes at edge region may elucidate a detailed picture peopling Here, we analyze whole-genome sequence 2,500-year-old individual (IK002) from main-island Japan that is characterized typical Jomon culture. The phylogenetic analyses support multiple waves migration, IK002 forming...
Poultry are farmed globally, with chicken (Gallus gallus domesticus) being the leading domesticated species. Although domestic bones have been reported from some Early Holocene sites, their origin is controversial and there no reliable bone older than Middle Holocene. Here, we studied goose Tianluoshan—a 7,000-y-old rice cultivation village in lower Yangtze River valley, China—using histological, geochemical, biochemical, morphological approaches. Histological analysis revealed that one of...
Angiotensin II (Ang II) and Ang III stimulate aldosterone secretion by adrenal glomerulosa, but the angiotensin receptor subtypes involved effects of IV (1-7) are not clear. In vitro, different angiotensins were added to rat concentration in medium was measured. II-induced release blocked (30.3 ± 7.1%) an type 2 (AT2R) antagonist, PD123319. Candesartan, 1 (AT1R) also (42.9 4.8%). Coadministration candesartan PD123319 almost abolished release. A selective AT2R agonist, CGP42112, used confirm...
Introduction During the medieval period, cultural attitudes toward leprosy often involved exclusion of infected people from general society. People suffering were moved to live in separate places such as a specific district, village, or hospital. Such actions are social implications how disease and its sufferers viewed dealt with. This study aims investigate whether Kovuklukaya was inhabited by segregated lepers. Methods conducted examining diet individuals using stable isotope analysis bulk...
The previous excavation by Tanudirjo and our recent at Leang Sarru in the Talaud Islands, located between northern Sulawesi southern Mindanao, reveal intermittent human colonization marine exploitation these remote islands as early 35,000 to 32,000 B.P. evidence indicates that humans migrated colonized part of Wallacea ocean crossings over 100 km, equivalent migrations from Sahul, Sahul Bismarck Archipelago during late Pleistocene. 14 C dates obtained shell samples collected earlier...
In a recent report, ATP, which was possibly secreted by some intestinal bacteria, shown to cause colitis in mice via Th17 cell differentiation. However, the ATP-secreting bacteria have not been isolated and identified. present study, we report that Enterococcus gallinarum, is vancomycin-resistant Gram-positive coccus from humans, secretes ATP.
ABSTRACT Objective : The Okhotsk people were sedentary hunter–gatherer–fishers who lived and prospered in Sakhalin, Hokkaido, the Kurile Islands during 5th to 13th centuries AD. They expanded rapidly along northeastern coast of Hokkaido. We reconstructed infant feeding practices Moyoro population culture eastern Japan. Methods Stable isotope ratios 58 subadult human skeletons measured. Results results suggest that complementary foods with a relatively low carbon ratio consumed after weaning,...
Abstract It has been hypothesized that nitrogen fixation occurs in the human gut. However, whether gut microbiota truly this potential remains unclear. We investigated nitrogen-fixing activity and diversity of nitrogenase reductase (NifH) genes faecal humans, focusing on Papua New Guinean Japanese individuals with low to high habitual intake. A 15 N 2 incorporation assay showed significant enrichment all samples, irrespective host intake, which was also supported by an acetylene reduction...
In order to further understand the genetic status of Okhotsk people, who were distributed in southern coastal regions Sea during 5th–13th centuries, nucleotide variations hypervariable region (HVR) and coding mitochondrial DNA (mtDNA) analyzed. Targeting provides reliable information even from ancient DNAs that may have suffered post-mortem damage. MtDNA haplogroups 38 individuals classified according mtDNA lineages known northeastern Asian people. Comparisons haplogroup frequencies between...
Nine human remains were recovered from Shiraho-Saonetabaru Cave on Ishigaki Island, Okinawa Prefecture, Japan, between 2007 and 2009. Six of the nine samples produced well-preserved biogenic collagen, which was submitted to radiocarbon dating by accelerator mass spectrometry. Three (Nos. 2, 4, 8) fossil chamber dated 16 20 ka BP, can clearly be assigned Late Pleistocene. One animal bone same treated measured for independently also great antiquity (c. 12 BP). These dates are first concrete...