A5016532517- Forensic and Genetic Research
- T-cell and B-cell Immunology
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- vaccines and immunoinformatics approaches
- Forensic Anthropology and Bioarchaeology Studies
- Immune Cell Function and Interaction
- Genetic Associations and Epidemiology
- Sperm and Testicular Function
- Archaeology and ancient environmental studies
- Identification and Quantification in Food
- Molecular Biology Techniques and Applications
- Pacific and Southeast Asian Studies
- Pleistocene-Era Hominins and Archaeology
- Monoclonal and Polyclonal Antibodies Research
- Machine Learning in Bioinformatics
- RNA modifications and cancer
- Global Public Health Policies and Epidemiology
- Nutritional Studies and Diet
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Race, Genetics, and Society
- Child Nutrition and Water Access
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Universiti Malaysia Sarawak
2024
The Graduate University for Advanced Studies, SOKENDAI
2012-2021
National Institute of Genetics
2009-2021
University of Malaya
2008-2009
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across continent remains enigmatic. Here we report a large-scale survey autosomal from broad sample Asian human populations. Our results show that ancestry is strongly correlated with affiliations as well geography. Most populations relatedness within ethnic/linguistic groups, despite prevalent gene flow among More than 90% East (EA) haplotypes could be found in either Southeast...
The population history of the indigenous populations in island Southeast Asia is generally accepted to have been shaped by two major migrations: ancient "Out Africa" migration ∼50,000 years before present (YBP) and relatively recent Taiwan" expansion Austronesian agriculturalists approximately 5,000 YBP. Negritos are believed originated from migration, whereas majority Asians associated with expansion. We determined 86 mitochondrial DNA (mtDNA) complete genome sequences four Malaysian...
Abstract Background The human leukocyte antigen (HLA) region, the 3.8-Mb segment of genome at 6p21, has been associated with more than 100 different diseases, mostly autoimmune diseases. Due to complex nature HLA genes, there are difficulties in elucidating complete gene sequences especially haplotype structures by conventional sequencing method. We propose a novel, accurate, and cost-effective method for generating phase-defined genes using indexed multiplex next generation sequencing....
The Funadomari Jomon people were hunter-gatherers living on Rebun Island, Hokkaido, Japan c. 3500–3800 years ago. In this study, we determined the high-depth and low-depth nuclear genome sequences from a female (F23) male (F5), respectively. We genotyped DNA of F23 human leukocyte antigen (HLA) class-I genotypes phenotypic traits. Moreover, pathogenic mutation in CPT1A gene was identified both F5. provides metabolic advantages for consumption high-fat diet, its allele frequency is more than...
Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history these remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups Negrito, Senoi, Proto-Malay. Structural analyses indicated that although all OA are genetically closest to East Asian (EA) populations, they substantially distinct. identified affinity between...
The Jomon period of the Japanese Archipelago, characterized by cord-marked 'jomon' potteries, has yielded abundant human skeletal remains. However, genetic origins people and their relationships with modern populations have not been clarified. We determined a total 115 million base pair nuclear genome sequences from two individuals (male female each) Sanganji Shell Mound (dated 3000 years before present) Jomon-characteristic mitochondrial DNA haplogroup N9b, compared these those worldwide...
Human presence in Southeast Asia dates back to at least 40,000 years ago, when the current islands formed a continental shelf called Sundaland. In Philippine Islands, Peninsular Malaysia, and Andaman there exist indigenous groups collectively Negritos whose ancestry can be traced "First Sundaland People." To understand relationship between these Negrito their demographic histories, we generated genome-wide single nucleotide polymorphism data compared them with existing from other...
The Japanese Archipelago stretches approximately 3,000 kilometers from Hokkaido in the north to Ryukyu Islands south, and has seen human activity since at least 30 thousand years ago (KYA). Jomon period 16 3 KYA is associated with cord-marked pottery people that time, who were hunter-gatherers, occupied a range of locations across Archipelago. Yayoi 1.7 saw introduction migrants Asian Continent brought rice agriculture archipelago. dual-structure model, which based on craniofacial...
This is the first report of high-resolution human leukocyte antigen (HLA) typing in four indigenous groups Malaysia. A total 99 normal, healthy participants representing Negrito (Jehai and Kensiu), Proto-Malay (Temuan) a native group Borneo (Bidayuh) were typed for HLA-A, -B, -DRB1 -DQB1 genes using sequence-based typing. Eleven 26 HLA-B, 16 HLA-DRB1 14 HLA-DQB1 alleles detected, including new allele, HLA-B*3589 Jehai. Highly frequent A*2407, B*1513, B*1801, DRB1*0901, DRB1*1202, DRB1*1502,...
Southeast Asia houses various culturally and linguistically diverse ethnic groups. In Malaysia, where the Malay, Chinese, Indian groups form majority, there exist minority such as “negritos” who are believed to be descendants of earliest settlers Asia. Here we report patterns genetic substructure admixture in two Malaysian negrito populations (Jehai Kensiu), using ∼50,000 genome-wide single-nucleotide polymorphism (SNP) data. We found traces recent both populations, particularly Jehai, with...
Previous studies suggested two major migration events during the Jomon and Yayoi periods that affected genetic diversity of modern Japanese (Yaponesians). We explored possibility a three-wave model by examining three datasets human DNA: (1) whole mitochondrial (mt) DNA genomes 1642 Yaponesians; (2) mtDNA haplogroup frequencies 59105 Yaponesians from 47 prefectures; (3) genome-wide SNP data (Ainu, Okinawa) whole-genome sequence Yamato individuals, Funadomari F23 individual, East Asian...
Abstract Objectives. Health scenarios are constantly evolving, particularly in developing countries but little is known regarding the health status of indigenous groups Malaysia. This study aims to elucidate current four populations country, who by and large been left out mainstream healthcare developments. Methods. Participants were recruited from Temuan, Jehai, Kensiu Bidayuh throughout Peninsula Malaysia Sarawak. parameters including body mass index (BMI), blood pressure, casual glucose...
The "Dual Structure" model on the formation of modern Japanese population assumes that indigenous hunter-gathering (symbolized as Jomon people) admixed with rice-farming Yayoi who migrated from Asian continent after period started. component remained high both in Ainu and Okinawa people mainly reside northern southern Japan, respectively, while is higher mainland (Yamato people). has been well supported by genetic data, but Yamato was mostly represented Tokyo area. We generated new...
A novel human leukocyte antigen‐B allele officially named B*3589, was found in an indigenous individual of Jehai ethnicity when sequencing performed to investigate genome variation a research project. B*3589 differs form B*3505 point mutation at codon 169 (CGC TGC) resulting amino acid change from Arg Cys.
The heterogenous population of Malaysia includes more than 50 indigenous groups, and characterizing their HLA diversity would not only provide insights to ancestry, but also on the effects natural selection genome. We utilized hybridization-based sequence capture short-read sequencing region 172 individuals representing seven groups in (Jehai, Kintaq, Temiar, Mah Meri, Seletar, Temuan, Bidayuh). Allele haplotype frequencies HLA-A, -B, -C, -DRB1, -DQA1, -DQB1, -DPA1, -DPB1 revealed several...
Southeast Asia houses various culturally and linguistically diverse ethnic groups.In Malaysia, where the Malay, Chinese, Indian groups form majority, there exist minority such as "negritos" who are believed to be descendants of earliest settlers Asia.Here we report patterns genetic substructure admixture in two Malaysian negrito populations ( Jehai Kensiu), using ~50,000 genomewide single-nucleotide polymorphism (SNP) data.We found traces recent both populations, particularly Jehai, with...
Southeast Asia houses various culturally and linguistically diverse ethnic groups. In Malaysia, where the Malay, Chinese, Indian groups form majority, there exist minority such as “negritos” who are believed to be descendants of earliest settlers Asia. Here we report patterns genetic substructure admixture in two Malaysian negrito populations (Jehai Kensiu), using ~50,000 genome-wide single-nucleotide polymorphism (SNP) data. We found traces recent both populations, particularly Jehai, with...