A5078548009- T-cell and B-cell Immunology
- Genomics and Phylogenetic Studies
- Forensic and Genetic Research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Genetic diversity and population structure
- Genomic variations and chromosomal abnormalities
- Pacific and Southeast Asian Studies
- Cancer, Hypoxia, and Metabolism
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Forensic Anthropology and Bioarchaeology Studies
- Gut microbiota and health
- Oral microbiology and periodontitis research
- Pharmacogenetics and Drug Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pleistocene-Era Hominins and Archaeology
- Metabolomics and Mass Spectrometry Studies
- Hormonal Regulation and Hypertension
- Immune Response and Inflammation
- Virology and Viral Diseases
- Malaria Research and Control
- Archaeology and ancient environmental studies
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
Monash University Malaysia
2015-2024
Sunway University
2009-2015
Monash University
2009-2012
University of Malaya
1991-2009
University of Cambridge
1993-1994
Addenbrooke's Hospital
1993
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across continent remains enigmatic. Here we report a large-scale survey autosomal from broad sample Asian human populations. Our results show that ancestry is strongly correlated with affiliations as well geography. Most populations relatedness within ethnic/linguistic groups, despite prevalent gene flow among More than 90% East (EA) haplotypes could be found in either Southeast...
The human occupation history of Southeast Asia (SEA) remains heavily debated. Current evidence suggests that SEA was occupied by Hòabìnhian hunter-gatherers until ~4000 years ago, when farming economies developed and expanded, restricting foraging groups to remote habitats. Some argue agricultural development indigenous; others favor the "two-layer" hypothesis posits a southward expansion farmers giving rise present-day Asian genetic diversity. By sequencing 26 ancient genomes (25 from SEA,...
The population history of the indigenous populations in island Southeast Asia is generally accepted to have been shaped by two major migrations: ancient "Out Africa" migration ∼50,000 years before present (YBP) and relatively recent Taiwan" expansion Austronesian agriculturalists approximately 5,000 YBP. Negritos are believed originated from migration, whereas majority Asians associated with expansion. We determined 86 mitochondrial DNA (mtDNA) complete genome sequences four Malaysian...
Indigenous populations of Malaysia known as Orang Asli (OA) show huge morphological, anthropological, and linguistic diversity. However, the genetic history these remained obscure. We performed a high-density array genotyping using over 2 million single nucleotide polymorphisms in three major groups Negrito, Senoi, Proto-Malay. Structural analyses indicated that although all OA are genetically closest to East Asian (EA) populations, they substantially distinct. identified affinity between...
Human presence in Southeast Asia dates back to at least 40,000 years ago, when the current islands formed a continental shelf called Sundaland. In Philippine Islands, Peninsular Malaysia, and Andaman there exist indigenous groups collectively Negritos whose ancestry can be traced "First Sundaland People." To understand relationship between these Negrito their demographic histories, we generated genome-wide single nucleotide polymorphism data compared them with existing from other...
The frequency and magnitude of dengue epidemics continue to increase exponentially in Malaysia, with a shift the age range predominance toward adults an expansion rural areas. Despite this, information pertaining extent transmission virus (DENV) community is lacking. This community-based pilot study was conducted establish DENV seroprevalence amongst healthy district Southern identify influencing factors. In this undertaken between April May 2015, total 277 adult participants were recruited...
Radical new possibilities of improved treatment cancer are on offer from an advanced medical technology already demonstrating its significance: next-generation sequencing (NGS). This refined testing provides unprecedentedly precise diagnoses and permits the use focused highly personalized treatments. However, across regions globally, many patients will continue to be denied benefits NGS as long some yawning gaps in implementation remain unattended. The challenges at regional national levels...
South East Asia (SEA) is home to over 30 tribes of indigenous population groups who are currently facing rapid socio-economic change. Epidemiological transition and increased prevalence non-communicable diseases (NCD) has occured. In Peninsular Malaysia, the Orang Asli (OA) people comprise 0 · 6% (150,000) live in various settlements. OA three distinct large with smaller sub-tribes. The include Proto-Malay (sub-tribes: Seletar Jakun), Senoi Mahmeri Semai), Negrito Jehai, Mendriq Batek).We...
Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome in which affected individuals have greatly increased predisposition to the development of haemangioblastomas central nervous system and retina, renal cell carcinoma phaeochromocytoma. The VHL gene has been mapped chromosome 3p25-p26 by genetic linkage studies we previously demonstrated that tightly linked D3S601 locus (Zmax = 18.86 at theta 0.0) suggesting maps close gene. We constructed long range physical...
Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited familial cancer syndrome characterised by a predisposition to the development of retinal, cerebellar, and spinal haemangioblastomas, renal cell carcinoma, phaeochromocytoma. The gene for VHL has been mapped chromosome 3p25-p26 flanking markers identified. We report detailed genetic mapping locus in 38 families. Significant linkage was detected between D3S601 (Zmax = 18.86 at theta 0.0, CI 0.0-0.025), D3S18 11.42 0.03,...
Journal Article Genetic linkage between Von Hippel—Lindau disease and three microsatellite polymorphisms refines the localisation of VHL locus Get access P.A. Crossey, Crossey Search for other works by this author on: Oxford Academic PubMed Google Scholar E.R. Maher, Maher * *To whom correspondence should be addressed at: Department Clinical Genetics, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK M.H. Jones, Jones 1Cancer InstituteTokyo, Japan F.M. Richards, Richards F. Latif,...
The human gut contains a complex microbiota dominated by bacteriophages but also containing other viruses and bacteria fungi. There are growing number of techniques for the extraction, sequencing, analysis virome currently no standardized protocols. This study established an effective workflow to investigate stool samples from two understudied ethnic groups Malaysia: Jakun Jehai Orang Asli. By using extraction with Oxford Nanopore Technology, long-read sequencing successfully captured close...
Journal Article Molecular genetic analysis of the 3p — syndrome Get access Maude E. Phipps, Phipps Search for other works by this author on: Oxford Academic PubMed Google Scholar Farida Latif, Latif 1Laboratory Immunobiology, National Cancer Institute, Frederick FacilityFrederick, MD, USA Amanda Prowse, Prowse Stewart J. Payne, Payne 2Molecular Genetics Laboratory, Addenbrooke's HospitalCambridge, UK Jeanne Dietz-Band, Dietz-Band 3Oncor Inc209 Perry Parkway, Gaithersberg, MD 20877, Margaret...
Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share common amino acid sequence at residues 70-74. This represents the first study to investigate association genes susceptibility RA amongst Malay, Chinese and Indian ethnic groups in Malaysia. One hundred thirty three patients one sixty seven healthy controls were recruited. The studied using Phototyping method. subtypes HLA-DR4 detected by "high...
In human immunodeficiency virus (HIV) patients, neuropathy is a common adverse side effect to some antiretroviral treatments, particularly stavudine. As stavudine cheap, it widely used in Asia and Africa. We showed that increasing age height moderately predict the development of neuropathy. This was improved by inclusion tumour necrosis factor (TNF)‐1031 (rs1799964). To investigate this association, Malay ( n = 64), Chinese 74) Caucasian patients 37) exposed were screened for DNA samples...
Abstract The region of northern Borneo is home to the current state Sabah, Malaysia. It located closest southern Philippine islands and may have served as a viaduct for ancient human migration onto or off Island. In this study, five indigenous ethnic groups from Sabah were subjected genome‐wide SNP genotyping. These individuals represent “North Borneo”‐speaking group great Austronesian family. They traditionally resided in inland Sabah. dataset was merged with public datasets, genetic...