A5081484221- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Aortic aneurysm repair treatments
- Gastrointestinal disorders and treatments
- Lymphatic System and Diseases
- Abdominal vascular conditions and treatments
- Metastasis and carcinoma case studies
- Pediatric Hepatobiliary Diseases and Treatments
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Simulation-Based Education in Healthcare
- Intraperitoneal and Appendiceal Malignancies
- Fibroblast Growth Factor Research
- Anesthesia and Pain Management
- Leptospirosis research and findings
- Head and Neck Cancer Studies
- Cytomegalovirus and herpesvirus research
- Case Reports on Hematomas
- Vascular Tumors and Angiosarcomas
Tohoku Medical and Pharmaceutical University
2025
Kasugai Municipal Hospital
2018-2024
Hyogo University
2024
Tokyo University of Agriculture and Technology
2024
Nishijin Hospital
2023
Nara Medical University
2017-2023
Tokyo Medical and Dental University
2016-2023
The University of Tokyo
2023
National Center for Global Health and Medicine
2020-2022
Hokkaido University
2019-2021
Staphylococcus aureus is a major causative agent for biofilm-associated infections. Inside biofilms, S. cells are embedded in an extracellular matrix (ECM) composed of polysaccharide-intercellular adhesins (PIA), proteins, and/or DNA (eDNA). However, the importance each component and relationship among them biofilms diverse strains largely unclear. Here, we characterised formed by 47 clinical isolates. In most (42/47) strains, biofilm formation was augmented glucose supplementation. Sodium...
Biofilm-forming bacteria embedded in polymeric extracellular matrices (ECMs) that consist of polysaccharides, proteins and/or DNAs (eDNAs) acquire high resistance to antimicrobial agents and host immune systems. To understand molecular mechanisms biofilm formation maintenance develop therapeutic countermeasures against chronic biofilm-associated infections, reliable methods isolate ECMs are inevitable. In this study, we refined the ECM extraction method recently reported evaluated its...
In a recent report, ATP, which was possibly secreted by some intestinal bacteria, shown to cause colitis in mice via Th17 cell differentiation. However, the ATP-secreting bacteria have not been isolated and identified. present study, we report that Enterococcus gallinarum, is vancomycin-resistant Gram-positive coccus from humans, secretes ATP.
BackgroundMetastatic infections such as infective endocarditis and psoas abscess are serious complications of Staphylococcus aureus bacteremia because failure to identify these may result in relapse or poor prognosis. the present study, we determined predictive factors for metastatic infection due methicillin-sensitive S. bacteremia.MethodsA retrospective cohort study was conducted among patients with at Jikei University Hospital between January 2008 December 2012. Factors analyzed included...
A ciliated muconodular papillary tumor has been reported to be a peripheral low-grade malignant tumor, consisting of columnar cells and goblet with basaloid cell proliferation. Although tumors have not yet classified according the World Health Organization classification, they can pose diagnostic therapeutic problems. Here we report resected case computed tomography findings reminiscent adenocarcinoma, showing small irregular nodule adjacent intersegment pulmonary vein. There was no uptake...
The mortality rates for bacteremia due to Pseudomonas aeruginosa remain high. In our hospital, we performed retrospective analyses determine risk factors among patients with caused by P. aeruginosa.This cohort study was conducted adult at Jikei University Hospital. We analyzed factors, such as age, gender, underlying disease, initial antimicrobial treatment, and primary site of infection which these were predictive in bacteremia.One hundred thirty-four identified between April 2003 March...
Perioperative thromboembolism is the main consideration in carotid artery stenting (CAS). Precise evaluation of plaque components clinically important to reduce ischaemic complications since CAS mechanically pushes outwards, which releases debris into bloodstream.This study aimed determine whether high lipid core (LCP) assessed by catheter-based near-infrared spectroscopy (NIRS) associated with ipsilateral cerebral embolism diffusion-weighted magnetic resonance imaging during using a...
Excess surgical stress responses, caused by heightened nociception, can lead to elevated levels of postoperative inflammation, resulting in an increased incidence complications after surgery. We hypothesized that utilizing nociception monitor-guided multimodal general anesthesia would exert effects on outcomes (e.g., serum concentrations C-reactive protein (CRP) surgery, complications). This single-center, double-blinded, randomized trial enrolled ASA class I/II adult patients with normal...
Fluorescence polarization microscopy, which can visualize both position and orientation of fluorescent molecules, is useful for analyzing architectural dynamics proteins in vivo, especially that cytoskeletal such as actin. Fluorescent phalloidin conjugates SiR-actin be used F-actin probes fluorescence but a lack appropriate methods their introduction to living specimens tissues, embryos, whole animals hampers applications image the F-actin. To solve this problem, we have developed...
Staphylococcus epidermidis Esp, an extracellular serine protease, inhibits aureus biofilm formation and nasal colonization. To further expand the biotechnological applications of we developed a highly efficient economic method for purification recombinant Esp based on Brevibacillus choshinensis expression-secretion system.The esp gene was fused with N-terminal Sec-dependent signal sequence B. cell wall protein C-terminal hexa-histidine-tag gene. The expressed secreted into optimized medium...
Knowledge on the pattern of recurrence and prognosis intraductal papillary neoplasms bile duct (IPNB) is limited. Few studies have reported IPNB in remnant intrahepatic duct, which indicative true multicentricity IPNB. Herein, we report a case with rapidly progressive review literature for discussing multicentricity.A 72-year-old male was diagnosed hepatic segment 3 that had spread to left duct. The patient underwent hepatectomy, total caudate lobectomy, extra-hepatic resection biliary...
OBJECTIVES: This study was conducted to clarify the rate of late diagnosis HIV infection and identify relationships between reasons for testing a diagnosis.METHODS: retrospective cohort among HIV-positive patients at Jikei University Hospital 2001 2014.Patient characteristics from medical records, including age, sex, sexuality, reason number CD4-positive lymphocytes diagnosis, were assessed.RESULTS: A total 459 (men, n=437; 95.2%) included in this median age 36 years (range, 18-71...
Pravastatin sodium is reported to have multiple beneficial effects in cerebral atherosclerosis and neuronal injury; however, the preventive on venous ischemia are still unknown. Herein, we aimed examine neuroprotective of transoral prior administration pravastatin against cortical with suppression apoptosis.Thirty 8-week-old male Wistar rats were divided equally into two study groups (n = 15 vs. n 15); group was fed 1% their usual diet for 2 weeks, while control only received diet. Two-vein...
Carotid artery stenting (CAS) is performed as a treatment for carotid stenosis. However, lipid-rich plaques cause embolic complications and sequelae. Near-infrared spectroscopy (NIRS) can identify lipid components by applying near-infrared absorption pattern, the distribution of be evaluated maximum core burden index (maxLCBI). Intravascular ultrasound (IVUS) equipped with NIRS has been clinically applied recently, its diagnostic usefulness validation have reported coronary arteries;...
Abstract Objective Fibroblast growth factor receptor gene alterations have emerged as promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer that has poor prognosis. This study evaluated the frequency of fibroblast 2 fusions in clinical specimens from Japanese patients with iCCA. Methods enrolled 116 who had histologically or cytologically confirmed adenocarcinoma and been diagnosed relapsing after resection unresectable cholangiocarcinoma. We fusions-positive cells their...
Neurofilaments are intermediate filament proteins specific for neurons and characterized by formation of biochemically stable, obligate heteropolymers in vivo While purified or reassembled neurofilaments have been subjected to morphological analyses electron microscopy atomic force microscopy, there has a need direct imaging cytoplasmic genuine filaments with minimal risk artefactualization. In this study, we applied the modified 'cells on glass sandwich' method exteriorize intracellular...