A5024555103- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Sarcoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Sarcoidosis and Beryllium Toxicity Research
- Colorectal Cancer Treatments and Studies
Toho University
2015-2024
Toho University Omori Medical Center
2014-2023
University Medical Center
2015-2021
University Hospital and Clinics
2015-2021
Yokohama City University Medical Center
2021
Yokohama City University
2021
Kashiwa Municipal Hospital
2021
Peking University First Hospital
2012-2017
Peking University
2012-2017
National Institute of Infectious Diseases
2014
ABSTRACT Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by reactive oxygen species produced phagocytic cells. Detoxification hydrogen peroxide catalases was proposed as way to overcome this host response. A. produces three active catalases; one conidia, and two are mycelia. The mycelial catalase Cat1p studied previously. Here we characterized other catalases, their genes, phenotypes gene-disrupted mutants. CatAp, spore-specific monofunctional catalase,...
Abstract Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed to inactivation the MMR genes, hMLH1 hMSH2. CRC with low (MSI-L) exists; however, its molecular basis unclear. There another type MSI—elevated microsatellite alterations selected tetranucleotide (EMAST)—where loci containing [AAAG]n or [ATAG]n unstable. EMAST frequent non-CRCs; incidence cause not...
Abstract Interleukin (IL)-11 is a member of the IL-6 family cytokines and involved in multiple cellular responses, including tumor development. However, origin functions IL-11-producing (IL-11 + ) cells are not fully understood. To characterize IL-11 vivo, we generate Il11 reporter mice. appear colon murine acute colitis models. Il11ra1 or deletion attenuates development colitis-associated colorectal cancer. express fibroblast markers genes associated with cell proliferation tissue repair....
Lymphangioleiomyomatosis (LAM) affects exclusively women of reproductive age, involves the lungs and axial lymphatic system, is frequently complicated with renal angiomyolipomas. LAM lesions are generated by proliferation cells mutations one tuberous sclerosis complex (TSC) genes. Recent studies indicate that can migrate or metastasize to form new in multiple organs, although they show a morphologically benign appearance. In previous study, we reported LAM-associated lymphangiogenesis...
Although gangliocytic paraganglioma (GP) has generally been regarded as a neuroendocrine tumor, its origin remains unclear. We therefore aimed to investigate the details of this disease by carefully analyzing and extracting common features presented in selected publications.We searched for English Japanese cases GP using PubMed IgakuChuoZasshi databases on August 2010. then extracted sampled raw data from publications performed appropriate statistical analyses. Additionally, we evaluated...
Abstract Gastrointestinal colonization has been considered as the primary source of candidaemia; however, few established mouse models are available that mimic this infection route. We therefore developed a reproducible model invasive candidiasis initiated by fungal translocation and compared virulence six major pathogenic Candida species. The mice were fed low-protein diet then inoculated intragastrically with cells. Oral antibiotics cyclophosphamide administered to facilitate subsequent...
To clarify the clinical characteristics and risk factors for acute respiratory deterioration following anti-cancer therapy in patients with pulmonary fibrosis (PF) lung cancer.Patients primary cancer PF were identified by review of medical records. Of 865 consecutive who had been treated between June 1999 September 2007, 53 diagnosed as having PF. This retrospective study analysed prevalence after treatment these patients.Acute was found 10 (24%) 41 received therapy, six (60%) died failure....
Protein phosphatases are critical for the regulation of many cellular processes. Null mutants 21 putative protein Candida albicans were constructed by consecutive allele replacement using URA3 and ARG4 marker genes. A simple silkworm model C. infection was used to screen panel mutants. Four null mutant (cmp1Delta, yvh1Delta, sit4Delta, ptc1Delta) strains showed attenuated virulence in relative that control parental strains. Three mutants, cmp1Delta, sit4Delta had previously been identified...
Pulmonary tumor thrombotic microangiopathy (PTTM) has been known as a rare and serious cancer-related pulmonary complication. However, the pathogenesis pathophysiology of this debilitating condition still remains obscure no effective management was recommended. The present study aims to elucidate PTTM.Autopsy records were searched extract cases embolism induced by metastasis gastric carcinoma in Toho University Omori Medical Center from 2000 2006. And then, tissue sections extracted prepared...
Abstract Background Although cardiac fibroma has been regarded as benign tumor, it presents various symptoms and may lead to death. Unfortunately, only a few studies have reported the epidemiology, embryology, histopathology of factors predicting poorer outcome are still obscured. Methods In July 2011 we searched for English Japanese cases using PubMed IgakuChuoZasshi databases. We then extracted sampled raw data from selected publications in accordance with Preferred Reporting Items...
A ciliated muconodular papillary tumor has been reported to be a peripheral low-grade malignant tumor, consisting of columnar cells and goblet with basaloid cell proliferation. Although tumors have not yet classified according the World Health Organization classification, they can pose diagnostic therapeutic problems. Here we report resected case computed tomography findings reminiscent adenocarcinoma, showing small irregular nodule adjacent intersegment pulmonary vein. There was no uptake...
Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this often misdiagnosed as neuroendocrine (NET) G1 (carcinoid tumor). However, patients with may have a better prognosis than NET G1. This fact emphasizes importance differentiating G1, but few studies reported epidemiology and histopathology because its rarity. To differentiate ease, we...
Cryptococcus neoformans causes life-threatening diseases mainly in immunosuppressed hosts such as AIDS patients; C. gattii disseminated infections even healthy hosts. To identify the possible molecular mechanisms underlying this difference virulence, we investigated survival and histopathology of lung tissue wild-type CD4-depleted mice infected with H99 JP02 (the highly virulent strain isolated Japan); then compared dendritic cell (DC) cytokine release responses to different fractions from...
To gain insight into the histopathologic characteristics of fungal infection in acquired immunodeficiency syndrome (AIDS).A review was conducted histopathology for 162 patients with evident infection.The microscopic appearance esophageal candidiasis that common single organ involvement revealed necrotic debris containing proliferating hyphae at site mucosal erosions without invasion underlying tissue. The incidence oral and followed by pulmonary aspergillosis Candida infection. Eighteen had...