A5101530683- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Curcumin's Biomedical Applications
- Pharmacological Effects of Medicinal Plants
- Cancer, Lipids, and Metabolism
- Polyomavirus and related diseases
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
City of Hope
2019-2025
Beckman Research Institute
2019-2025
City Of Hope National Medical Center
2019-2025
Baylor University Medical Center
2015-2024
Baylor Medical Center at Garland
2016-2024
Homerton University Hospital NHS Foundation Trust
2024
Belfast Health and Social Care Trust
2024
University of Padua
2024
Shanghai Medical College of Fudan University
2023
Fudan University Shanghai Cancer Center
2017-2023
<h3>Objective</h3> Distant metastasis is the major cause of cancer-related death in patients with colorectal cancer (CRC). Although microRNA-200 (miR-200) family a crucial inhibitor epithelial-to-mesenchymal transition (EMT) human cancer, role miR-200 members pathogenesis metastatic CRC has not been investigated. <h3>Design</h3> Fifty-four pairs primary and corresponding matched liver tissue specimens were analysed for expression methylation status members. Functional analysis miR-200c...
BackgroundThe oncogenic microRNAs (miRNAs) miR-21 and miR-31 negatively regulate tumor-suppressor genes. Their potential as serum biomarkers has not been determined in human colorectal cancer (CRC).
Curcumin is known to possess potent antiinflammatory and antiarthritic properties. This pilot clinical study evaluated the safety effectiveness of curcumin alone, in combination with diclofenac sodium patients active rheumatoid arthritis (RA). Forty‐five diagnosed RA were randomized into three groups receiving (500 mg) (50 alone or their combination. The primary endpoints reduction Disease Activity Score (DAS) 28. secondary included American College Rheumatology (ACR) criteria for tenderness...
Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be potential miR-7 sponge. As miR-7, putative tumor-suppressor, regulates expression several important drivers colorectal cancer, we analyzed clinical significance ciRS-7 in patients.Experimental Design: Initially, evaluated levels training cohort comprising 153 primary tissues and 44 matched normal mucosae. We subsequently confirmed its relevance an...
Abstract Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available noninvasive screening programs have achieved only a modest decrease in mortality. MicroRNAs (miRNA) play an important role wide array biological processes and are commonly dysregulated neoplasia. We aimed to evaluate feasibility fecal miRNAs as biomarkers for colorectal neoplasia screening. Materials Methods: Total RNA was extracted from freshly collected stool samples...
To evaluate the ability of epithelial-to-mesenchymal transition-related microRNAs (miRNAs) as serum biomarkers for prognosis and prediction metastasis in patients with colorectal cancer (CRC).Epithelial-to-mesenchymal miRNAs drive CRC progression metastasis. However, their potential has not been studied.This was a 3-phase study using 446 specimens. In first phase, we selected candidate associated by analyzing expression 4 miR-200 family members (miR-200b, -200c, -141, -429) samples from 12...
Abstract Global downregulation of microRNAs (miRNA) is a common feature in colorectal cancer (CRC). Whereas CpG island hypermethylation constitutes mechanism for miRNA silencing, this field largely remains unexplored. Herein, we describe the epigenetic regulation miR-137 and its contribution to carcinogenesis. We determined methylation status panel six CRC cell lines 409 tissues [21 normal colonic mucosa from healthy individuals (N-N), 160 primary their corresponding (N-C), 68 adenomas]....
<h3>Objective</h3> Hypomethylation of LINE-1 elements has emerged as a distinguishing feature in human cancers. Limited evidence indicates that some encode an additional internal antisense promoter, and increased hypomethylation this region may lead to inadvertent activation evolutionarily methylation-silenced downstream genes. However, the significance fundamental epigenetic mechanism colorectal cancer (CRC) not been investigated previously. <h3>Design</h3> We analysed tissue specimens from...
The prognosis of gastric cancer (GC) patients with peritoneal dissemination remains poor, and a better understanding the underlying mechanisms is critical for development new treatments that will improve survival in these patients. This study aimed to clarify clinical biological role two key metastasis-associated long non-coding RNAs (lncRNAs) GC. We analyzed expression levels lncRNAs-Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) HOX-Antisense Intergenic RNA (HOTAIR)-by...
Background: Systemic inflammation via host-tumor interactions is currently recognized as a hallmark of cancer. The aim this study was to evaluate the prognostic value various combinations inflammatory factors using preoperative blood, and assess clinical significance our newly developed score in colorectal cancer (CRC) patients. Method: In total 477 CRC patients from discovery validation cohorts were enrolled study. We assessed predictive impact for recurrence combination nine markers set,...
Rationale: Colorectal cancer (CRC) is a malignant tumor with the third highest morbidity rate among all cancers. Driven by host's genetic makeup and environmental exposures, gut microbiome its metabolites have been implicated as causes regulators of CRC pathogenesis. We assessed human fecal samples noninvasive unbiased surrogates to catalog microbiota metabolome in patients CRC. Methods: Fecal collected from (CRC group, n = 50) healthy volunteers (H were subjected (16S rRNA gene sequencing)...