A5015781129- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Nuclear Structure and Function
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Microscopic Colitis
- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vitamin C and Antioxidants Research
- TGF-β signaling in diseases
- Synthesis and Characterization of Heterocyclic Compounds
- State Capitalism and Financial Governance
- Cancer, Lipids, and Metabolism
- Digestive system and related health
- Monoclonal and Polyclonal Antibodies Research
- Pediatric Hepatobiliary Diseases and Treatments
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
Toho University
2016-2025
Juntendo University
2011-2012
Tokyo University of Science
2009
The University of Tokyo
2009
In dying cells, reactive oxygen species stimulate the production of a cytokine that triggers healthy neighboring cells to proliferate.
Abstract Interleukin (IL)-11 is a member of the IL-6 family cytokines and involved in multiple cellular responses, including tumor development. However, origin functions IL-11-producing (IL-11 + ) cells are not fully understood. To characterize IL-11 vivo, we generate Il11 reporter mice. appear colon murine acute colitis models. Il11ra1 or deletion attenuates development colitis-associated colorectal cancer. express fibroblast markers genes associated with cell proliferation tissue repair....
The antiapoptotic protein c-FLIP blocks multiple cell death pathways in mice.
Abstract Liver fibrosis results from chronic liver injury triggered by factors such as viral infection, excess alcohol intake, and lipid accumulation. However, the mechanisms underlying are not fully understood. Here, we demonstrate that expression of fibroblast growth factor 18 ( Fgf18 ) is elevated in mouse livers following induction models. Deletion hepatocytes attenuates fibrosis; conversely, overexpression promotes fibrosis. Single-cell RNA sequencing reveals an increase number Lrat +...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5)-mediated cell death plays an important role in the elimination of tumor cells and transformed cells. Recently, recombinant TRAIL agonistic anti-DR5 monoclonal antibodies have been developed applied to cancer therapy. However, depending on type cancer, sensitivity has reportedly different, some are resistant TRAIL-mediated apoptosis. Using confocal microscopy, we found that large amounts DR5 were localized...
Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal its dysregulation associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family cytokines, produced fibroblasts during acute colitis. However, role IL-11 in development colitis still unclear. Herein, we showed that ameliorated DSS-induced mouse models. We found deletion Il11ra1 or Il11 rendered mice highly susceptible to compared respective control mice. The number...
Wnt5a, a representative Wnt ligand that activates the β-catenin-independent pathway, has been shown to promote tumorigenesis. However, it is unclear where Wnt5a produced and how affects colon cancer aggressiveness. In this study, we demonstrate expressed in fibroblasts near luminal side of tumor, its depletion suppresses mouse formation. To characterize specific fibroblast subtype, meta-analysis human single-cell RNA-seq data performed. The results show hypoxia-induced inflammatory (InfFib),...
The AP-1 transcription factor JunB plays crucial roles in multiple biological processes, including placental formation and bone homeostasis. We recently reported that is essential for development of Th17 cells, thus Junb-deficient mice are resistant to experimental autoimmune encephalomyelitis. However, the role CD4+ T cells under other inflammatory disease conditions unknown. Here we show lacking (Junbfl/flCd4-Cre mice) were more susceptible dextran sulfate sodium (DSS)-induced colitis...
A short form of cellular FLICE-inhibitory protein encoded by CFLARs promotes necroptosis. Although necroptosis is involved in various pathological conditions, the detailed mechanisms are not fully understood. Here we generated transgenic mice wherein was integrated onto X chromosome. All male Tg died perinatally due to severe ileitis. observed tissues mice, large numbers intestinal epithelial cells (IECs) apoptosis. Deletion Ripk3 or Mlkl, essential genes necroptosis, prevented both and...
Regenerating islet-derived protein (Reg)3β belongs to a member of the Reg family proteins and has pleiotropic functions, including antimicrobial activity tissue repair. However, whether Reg3β plays protective role in development colitis ileitis not been fully investigated. We generated transgenic mice expressing short form cellular FLICE-inhibitory (cFLIPs) that promotes necroptosis, regulated cell death. cFLIPs (CFLARs Tg) develop severe utero. Although is undetectable small intestine...
Abstract The loss-of-function mutations of serine protease inhibitor, Kazal type 1 ( SPINK1 ) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3 , murine homologue die perinatally due to massive pancreatic acinar cell death, precluding investigation effects deficiency. To circumvent perinatal lethality, we have developed a novel method integrate on X chromosome using Cre- lox P technology and thus...
Abstract TNF-related apoptosis-inducing ligand (TRAIL) and an agonistic antibody against the death-inducing TRAIL receptor 5, DR5, are thought to selectively induce tumor cell death therefore, have gained attention as potential therapeutics currently under investigation in several clinical trials. However, some cells resistant TRAIL/DR5–induced death, even though they express DR5. Previously, we reported that DR5 is transported into nucleus by importin β1, knockdown of β1 upregulates surface...
Type II alveolar epithelial cells (AEC2s) play a crucial role in the regeneration of type I AECs after acute lung injury. The mechanisms underlying AEC2s are not fully understood. To address this issue, here, we investigated murine model injury using mice expressing human Diphtheria Toxin Receptor (DTR) under control Lysozyme M promoter (LysM-DTR). DT injection induced depletion AEC2s, macrophages, and bone marrow (BM)-derived myeloid LysM-DTR mice, died within 6 days injection. Apoptotic...
Control of gut microbes is crucial for not only local defense in the intestine but also proper systemic immune responses. Although intestinal epithelial cells (IECs) play important roles cytokine-mediated control enterobacteria, underlying mechanisms are fully understood. Here we show that deletion IκBζ IECs mice leads to dysbiosis with marked expansion segmented filamentous bacteria (SFB), thereby enhancing Th17 cell development and exacerbating inflammatory diseases. Mechanistically,...
SUMMARY Interleukin (IL)-11 is a member of the IL-6 family cytokines and involved in multiple cellular responses, including tumor development. However, origin functions IL-11-producing (IL-11 + ) cells are not fully understood. To characterize IL-11 vivo , we generated Il11 reporter mice. appeared colon three murine models, acute colitis model. Il11ra1 or deletion attenuated development colitis-associated colorectal cancer. expressed fibroblast markers, genes associated with cell...
<p>Immunohistochemistry and image analysis, Apoptosis induction in shRNA-transduced importin β1 knockdown HeLa cells with administration of agonistic anti-hDR5 mAb (CS-1008) vivo, Antitumor effect via atelocollagen delivery shRNA combination CS-1008 on HepG2 xenograft models, Effect importazole apoptosis by rTRAIL vitro, Body weights the mice during treatment and/or experiments presented Fig. 6, Importin expression tumor tissues dissected from treated hIgG doxycycline 3A B.</p>
<p>Immunohistochemistry and image analysis, Apoptosis induction in shRNA-transduced importin β1 knockdown HeLa cells with administration of agonistic anti-hDR5 mAb (CS-1008) vivo, Antitumor effect via atelocollagen delivery shRNA combination CS-1008 on HepG2 xenograft models, Effect importazole apoptosis by rTRAIL vitro, Body weights the mice during treatment and/or experiments presented Fig. 6, Importin expression tumor tissues dissected from treated hIgG doxycycline 3A B.</p>