A5101789789- Hydraulic Fracturing and Reservoir Analysis
- Drilling and Well Engineering
- Additive Manufacturing Materials and Processes
- Peptidase Inhibition and Analysis
- High Entropy Alloys Studies
- Epigenetics and DNA Methylation
- Seismic Imaging and Inversion Techniques
- Cancer-related gene regulation
- Chemokine receptors and signaling
- Immune cells in cancer
- Rock Mechanics and Modeling
- Groundwater flow and contamination studies
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Oil and Gas Production Techniques
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- Intermetallics and Advanced Alloy Properties
- RNA modifications and cancer
- Geotechnical and Geomechanical Engineering
- Surface Treatment and Residual Stress
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2016-2025
Southwest Petroleum University
2016-2025
East China University of Science and Technology
2023-2024
Air Force Medical University
2022-2023
Toho University
2023
Nantong University
2020-2022
Xiangya Hospital Central South University
2017-2020
Central South University
2017-2020
Affiliated Hospital of Nantong University
2020
Hunan Provincial Center for Disease Control and Prevention
2020
The first fractured shale gas well of China was constructed in 2010. After 10 years development, has become the second country that possesses core technology development around world, realized fracturing techniques from zero to one and lagging partially leading, theory system suitable for middle–shallow marine exploitation. In order provide beneficial guidance efficient exploitation future, this paper comprehensively reviews history status domestic fundamental theories, optimized design...
Aiming at analyzing the issues of non-uniform growths multiple hydraulic fractures caused by stress shadowing, a numerical model considering elasto-hydrodynamic, interference and flow distribution into different was presented. Based on model, effects perforation friction, cluster spacing, Young modulus rock fracturing fluid viscosity growth were investigated. The simulation results show that are relatively uniform with adequate friction; reduction increase or will cause some fracture width...
Abstract Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but mechanism remains unclear. GABAergic neurons substantia nigra pars reticulata (SNr) contribute to motor deficit HE. The present study aims investigate effects oxidative on HE male mice. results validate existence both liver and SNr across two murine models induced by thioacetamide (TAA) bile duct ligation (BDL). Systemic mitochondria-targeted antioxidative drug mitoquinone (Mito-Q) rescues...
Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated (M2 TAMs) that promote cancer progression. However, communicative mechanisms between TAMs and cells squamous cell carcinoma of head neck (SCCHN) remain largely unknown. Quantitative real-time PCR, western blotting, enzyme-linked immunosorbent assay flow cytometry were applied to quantify mRNA protein expression genes related TAMs, epithelial–mesenchymal transition (EMT) stemness. Wounding-healing...
Abstract Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of head neck (SCCHN). However, mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine key microRNA their functional involved metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used quantify level miR‐30e‐5p its clinical significance further analyzed. A series vitro vivo experiments were applied...
Abstract Multistage multicluster hydraulic fracturing is currently the most effective method to stimulate low‐permeability hydrocarbon reservoirs. The desired result of this stimulation technique highly uniform growth multiple closely spaced fractures. In order deepen our understanding on competitive these fractures, we have investigated behaviors fractures under different conditions. A fully coupled model with a 3‐D influence coefficient presented for fracture in rock layer, based...
Abstract The canonical Wnt/β‐catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt‐mediated radioresistance remains unclear. In this study, we found that irradiation activated autophagic pathways squamous cell carcinoma head neck (SCCHN). Wnt3a is a classical ligand pathway, induced decreased sensitivity SCCHN to both vitro vivo. Further mechanistic analysis revealed promoted via protective autophagy. Finally, expression protein was...
Invasion and metastasis represent the primary causes of therapeutic failure in patients diagnosed with squamous cell carcinoma head neck (SCCHN). Therefore, disease prediction inhibition invasion are critical for enhancing survival SCCHN. Our previous study revealed that increased expression miR-93-5p is associated poor prognosis SCCHN; however, mechanism underlying oncogenic functions SCCHN migration remains unclear. Using qPCR analyses, transwell assays, scratch tests, we demonstrated...
Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal its dysregulation associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family cytokines, produced fibroblasts during acute colitis. However, role IL-11 in development colitis still unclear. Herein, we showed that ameliorated DSS-induced mouse models. We found deletion Il11ra1 or Il11 rendered mice highly susceptible to compared respective control mice. The number...
Abstract Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma head and neck (SCCHN). Our previous study showed that chemokine (C‐C motif) ligand 18 (CCL18), derived from tumour‐associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithelial‐mesenchymal transition (EMT) preserving stemness. However, underlying mechanism needs to be further investigation. Interestingly, metadherin (MTDH) expression was induced when cells were...
It has become a consensus that large-scale hydraulic fracturing is adopted to achieve the stimulation of unconventional oil and gas reservoir. The complex fracture network formed by closely related effect reservoir stimulation, which extremely complicated evolution process. Therefore, it necessary study law in reservoirs. In this article, geological engineering parameters horizontal well H shale southern Sichuan are taken as an example, three-dimensional expansion model established based on...
Hydraulic fracturing is a key technology to build productivity in shale reservoirs; however, the evolution mechanism of fractures extremely complex, especially reservoirs with natural weak-planes development. There an urgent need conduct systematic research on influence weak planes vertical propagation hydraulic fractures. This article takes deep gas block Luzhou Southern Sichuan as basis and conducts different conditions true triaxial large-scale physical simulation experiments well...
Fluid-solid coupling in fractured reservoirs plays a critical role for optimizing and managing energy geophysical engineering. Computational difficulties associated with sharp fracture models motivate phase field modeling. However, geomechanical problems, the fully coupled hydromechanical modeling framework is still under development. In this work, we propose fluid-solid model, which discrete fractures are regularized by field. Specifically, model takes into account complex interaction of...